Functional characterization of NCAM fibronectin type III domains: Demonstration of modulatory effects of the proline-rich sequence encoded by alternatively spliced exons a and AAG

Journal of Neuroscience Research

Volumn 46, Issue 2, 1996, Pages 173-186

  Kasper, Christina ^a   Stahlhut, Martin ^a   Berezin, Vladimir ^a   Maar, Thomas E ^a   Edvardsen, Klaus ^a   Kiselyov, Vladislav V ^a   Soroka, Vladislav ^a   Bock, Elisabeth ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

cell aggregation; cell morphology; fibronectin type III domains; growth cone; neural cell adhesion molecule (NCAM)

Indexed keywords

COMPLEMENTARY DNA; DNA FRAGMENT; FIBRONECTIN; HYBRID PROTEIN; MALTOSE BINDING PROTEIN; NERVE CELL ADHESION MOLECULE; POLYCLONAL ANTIBODY; PROLINE;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL LINE; CELL SPREADING; CELL STRUCTURE; CONTROLLED STUDY; EXON; GRANULE CELL; GROWTH CONE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN IMMOBILIZATION; PROTEIN VARIANT; SEQUENCE HOMOLOGY;

ANIMALS; BLOTTING, WESTERN; CELL COMMUNICATION; CEREBELLUM; EXONS; FIBRONECTINS; IMMUNOGLOBULIN FAB FRAGMENTS; L CELLS (CELL LINE); MICE; NEURAL CELL ADHESION MOLECULES; NEURITES; PROLINE; RATS;

EID: 0029911373     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19961015)46:2<173::AID-JNR5>3.0.CO;2-E     Document Type: Article

References (52)

1. Andersson A-M, Gaardsvoll H, Giladi E, Dahl B, Bock E (1990): Characterization of rat brain NCAM mRNA probes using DNA oligonucleotide probes. FEBS Lett 263:385-388.
2. Barthels D, Santoni M-J, Wille W, Ruppert C, Chaix J-C, Hirsch M-R, Fontecilla-Camps JC, Goridis C (1987): Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without at a membrane-spanning region. EMBO J 6:907-914.
3. Becker JW, Erickson HP, Hoffman S, Cunningham BA, Edelman GM (1989): Topology of cell adhesion molecules. Proc Natl Acad Sci USA 86:1088-1092.
4. Burgoon MP, Hazan RB, Phillips GR, Crossin KL, Edelman GM, Cunningham BA (1995): Functional analysis of posttranslational cleavage products of the neuron-glia cell adhesion molecule, Ng-CAM. J Cell Biol 130:733-744.
5. Carpén O, Pallai P, Staunton DE, Springer TA (1992): Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and α-actinin. J Cell Biol 118:1223-1234.
6. Cole GJ, Akeson R (1989): Identification of a heparin binding domain of the neural cell adhesion molecule N-CAM using synthetic peptides. Neuron 2:1157-1165.
7. Cole GJ, Glaser L (1986): A heparin binding domain from N-CAM is involved in neural cell-substratum adhesion. J Cell Biol 102: 403-412.
8. Connolly L, Seely JP, Greene LA (1987): Rapid regulation of neuronal growth cone shape and surface morphology by nerve growth factor, Neurochem Res 12:861-868.
9. Doherty P, Walsh FS (1994): Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules. Curr Opin Neurobiol 4:49-55.
10. 2+ channels. Cell 67:21-33.
11. Doherty P, Moolenar CE, Ashton SV, Michalides RJ, Walsh FS (1992): The VASE exon downregulates the neurite growth-promoting activity of NCAM 140. Nature 356:791-793.
12. Durbec P, Gennarini G, Buttiglione M, Gomez S, Rougon G (1994): Different domains of the F3 neuronal adhesion molecule are involved in adhesion and neurite outgrowth promotion. Eur J Neurosci 6:461-472.
13. Edelman GM (1988): Morphoregulatory molecules. Biochem 27: 3533-3543.
14. Frei T, von Bohlen und Halbach F, Wille W, Schachner M (1992): Different extracellular domains of the neural cell adhesion molecule (N-CAM) are involved in different functions. J Cell Biol 118:177-194.
15. Frick I-M, Crossin K-L, Edelman GM, Björck L (1995): Protein H - a bacterial surface protein with affinity for both immunoglobulin and fibronectin type III domains. EMBO J 14:1674-1679.
16. Friedlander DR, Milev P, Karthikeyan L, Margolis RK, Margolis RU, Grumet M (1994): The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J Cell Biol 125:669-680.
17. Gundersen RW (1987): Response of sensory neurites and growth cones to patterned substrata of laminin and fibronectin in vitro. Dev Biol 121:423-431.
18. Hall A, Rutishauser U (1987): Visualization of neural cell adhesion molecule by electron microscopy. J Cell Biol 104:1579-1586.
19. Harboe N, Ingild A (1973): Immunization, isolation of immunoglobulins, estimation of antibody titres. Scand J Immunol Suppl 1:161-164.
20. Horstkorte R, Schachner M, Magyar JP, Vorherr T, Schmitz B (1993): The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with LI and neurite outgrowth. J Cell Biol 121:1409-1421.
21. Ibsen S, Berezin V, Nørgaard-Pedersen B, Bock E (1983): Enzyme-linked immunosorbent assay of the D2-glycoprotein. J Neurochem 41:356-362.
22. Jørgensen OS, Bock E (1974): Brain specific synaptosomal membrane proteins demonstrated by crossed immunoelectrophoresis. J Neurochem 23:879-880.
23. Kadmon G, Kowitz A, Altevogt P, Schachner M (1990): Functional cooperation between the neural cell adhesion molecules L1 and N-CAM is carbohydrate dependent. J Cell Biol 110:209-218.
24. Laemmli UK (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
25. Letourneau PC, Shattuck TA (1989): Distribution and possible interactions of actin-associated proteins and cell adhesion molecules of nerve growth cones. Development 105:505-519.
26. Liu L, Haines S, Shew R, Akeson RA (1993): Axon growth is enhanced by NCAM lacking the VASE exon when expressed in either the growth substrate or the growing axon. J Neurosci Res 35:327-345.
27. Maar T, Morán J, Schousboe A, Pasantes-Morales H (1995): Taurine deficiency in dissociated mouse cerebellar cultures affects neuronal migration. Int J Dev Neurosci 13:491-502.
28. Mayford M, Barzilai A, Keller F, Schachner S, Kandel ER (1992): Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. Science 256:638-644.
29. Milev P, Friedlander DR, Sakurai T, Karthikeyan L, Flad M, Margolis RK, Grumet M, Margolis RU (1994): Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatases with neurons, glia, and neural cell adhesion molecules. J Cell Biol 127:1703-1715.
30. Nisonoff A (1964): Enzymatic digestion of rabbit gamma globulin and antibody and chromatography of digestion products. Meth Med Res 10:134-141.
31. Olsen M, Krog L, Edvardsen K, Skovgaard LT, Bock E (1993): Intact transmembrane isoforms of the neural cell adhesion molecule are released from the plasma membrane. Biochem J 295:833-840.
32. Payne HR, Burden SM, Lemmon V (1992): Modulation of growth cone morphology by substrate-bound adhesion molecules. Cell Motil Cytoskeleton 21:65-73.
33. Pollerberg GE, Beck-Sickinger A (1993): A functional role for the middle extracellular region of the neural cell adhesion molecule (NCAM) in axonal fasciculation and orientation. Dev Biol 156: 324-340.
34. Pollerberg GE, Burridge K, Krebs K, Goodman SR, Schachner M (1987): The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions. Cell Tissue Res 250:227-236.
35. Probstmeier R, Kühn K, Schachner M (1989): Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix. J Neurochem 53:1794-1801.
36. Rao Y, Wu X-F, Gariepy J, Rutishauser U, Siu C-H (1992): Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM. J Cell Biol 118: 937-949.
37. Rasmussen S, Ramlau J, Axelsen NH, Bock E (1982): Purification of the synaptic membrane glycoprotein D2 from rat brain. Scand J Immunol 15:179-185.
38. Rutishauser U, Jessel TM (1988): Cell adhesion molecules in vertebrate neural development. Physiol Rev 68:819-857.
39. Rutishauser U, Hoffman S, Edelman GM (1982): Binding properties of a cell adhesion molecule from neural tissue. Proc Natl Acad Sci USA 79:685-689.
40. Rønn LC, Bock E, Linnemann D, Jahnsen H (1995): NCAM-antibodies modulate induction of long term potentiation in rat hippocampal CA1. Brain Res 677:145-151.
41. Saffell JL, Walsh FS, Doherty P (1994): Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum. J Cell Biol 125:427-436.
42. Sanger F, Nicklen S, Coulson AR (1977): DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467.
43. Santoni M-J, Barthels D, Barbas JA, Hirsch M-R, Steinmetz M, Goridis C, Wille W (1987): Analysis of cDNA clones that code for the transmembrane forms of the mouse neural cell adhesion molecule (NCAM) and are generated by alternative RNA splicing. Nucleic Acids Res 15:8621-8641.
44. Schousboe A, Meier E, Drejer J, Hertz L (1989): Preparation of primary cultures of mouse (rat) cerebellar granule cells. In Shahar A, De Vellis J, Vernadakis A, Haber B (eds): "Dissection and Tissue Culture. Manual of the Nervous System." New York: Alan R. Liss, Inc., pp 203-206.
45. Schuch U, Lohse MJ, Schachner M (1989): Neural cell adhesion molecules influence second messenger systems. Neuron 3:13-20.
46. Small SJ, Akeson R (1990): Expression of the unique NCAM VASE exon is independently regulated in distinct tissues during development. J Cell Biol 111: 2089-2096.
47. Soll DR, Voss E, Varnum-Finney B, Wessels D (1988): Dynamic morphology system: a method for quantitating changes in shape, pseudopod formation, and motion in normal and mutant amoebae of Dictyostelium discoideum. J Cell Biochem 37:177-192.
48. Southern EM (1975): Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503-517.
49. Trenkner E, Sidman RL (1977): Histogenesis of mouse cerebellum in microwell cultures. J Cell Biol 75:915-940.
50. Walsh FS, Parekh RB, Moore SE, Dickson G, Barton CH, Gower HJ, Dwek RA, Rademacher TW (1989): Tissue specific O-linked glycosylation of the neural cell adhesion molecule (N-CAM). Development 105:803-811.
51. Walsh FS, Furness J, Moore SE, Ashton S, Doherty P (1992): Use of the neural cell adhesion molecule VASE exon by neurons is associated with a specific down-regulation of neural cell adhesion molecule-dependent neurite outgrowth in the developing cerebellum and hippocampus. J Neurochem 59:1959-1962.
52. Williams EJ, Furness J, Walsh FS, Doherty P (1994): Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron 13:583-594.