Heavy metals inhibit Pi-induced currents through human brush-border NaPi-3 cotransporter in Xenopus oocytes

American Journal of Physiology - Renal Fluid and Electrolyte Physiology

Volumn 271, Issue 4 40-4, 1996, Pages

  Wagner, Carsten A ^b   Waldegger, Siegfried ^b   Osswald, Hartmut ^b   Biber, Jürg ^b   Murer, Heini ^b   Busch, Andreas E ^b   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NONE

Author keywords

Cadmium; Lead; Mercury; Phosphate; Transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HEAVY METAL; PARATHION; PHOSPHATE;

ANIMAL CELL; ARTICLE; BRUSH BORDER; CALCIUM BLOOD LEVEL; ENZYME ACTIVITY; MEMBRANE PERMEABILITY; NONHUMAN; OOCYTE DEVELOPMENT; OXIDATION; PHOSPHATE BLOOD LEVEL; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; XENOPUS;

2,2'-DIPYRIDYL; ANIMALS; CADMIUM; CARRIER PROTEINS; DISULFIDES; DITHIONITROBENZOIC ACID; ELECTRIC CONDUCTIVITY; FEMALE; HUMANS; KIDNEY; LEAD; LLC-PK1 CELLS; MERCURY; MICROVILLI; PHOSPHATES; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS; SWINE; SYMPORTERS; XENOPUS;

EID: 0029911350     PISSN: 03636127     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajprenal.1996.271.4.f926     Document Type: Article

References (21)

1. 1 cells: mechanisms of injury. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol 34): F377-F384, 1993.
2. Anner, B. M., M. Moosmayer, and E. Imesch. Mercury blocks Na-K-ATPase by a ligand-dependent and reversible mechanism. Am. J. Physiol. 262 (Renal Fluid Electrolyte Physiol. 31): F830-F836, 1992.
3. Biber, J., and H. Murer. Renal epithelial apical Na/Pi cotrans-porters. Cell. Physiol. Biochem. 4: 185-197, 1994.
4. + channels in Xenopus oocytes by isosorbide dinitrate. J. Physiol. Land. 491: 735-741, 1996.
5. i transporter. J. Am. Soc. Nephrol. 6:1547-1551, 1995.
6. i-cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 91: 8205-8208, 1994.
7. Greenberg, A., D. K. Parkinson, D. E. Fetterolf, J. B. Puschett, K. J. Ellis, L. Wielopolski, A. N. Vaswani, S. H. Cohn, and P. J. Landrigan. Effects of elevated lead and cadmium burdens on renal function and calcium metabolism. Arch. Environ. Health 41: 69-76, 1986.
8. Iturri, S. J., and A. Pena. Heavy metal-induced inhibition of active transport in the rat small intestine in vitro. Interactions with other ions. Comp. Biochem. Physiol. C 84: 363-368, 1986
9. Jungwirth, A., M. Ritter, M. Paulmichl, and F. Lang. Activation of cell membrane potassium conductance by mercury in cultured renal epitheloid (MDCK) cells. J. Cell. Physiol. 146: 25-33, 1991.
10. Knochel, J. P. The clinical and physiological implications of phosphorus deficiency. In: The Kidney: Physiology and Pathophysiology (2nd ed.), edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, p. 2533-2562.
11. +-Pi cotransporter by mercuric chloride: role of sulfhydryl groups. J. Cell. Biochem. 49: 199-207, 1992.
12. Magagnin, S., A. Werner, D. Markovich, V. Sorribas, G. Stange, J. Biber, and H. Murer. Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc. Natl. Acad. Sci. USA 90: 5979-83, 1993.
13. Miura, K., A. Nagaguma, S. Himeno, and N. Imura. Mercury toxicity. In: Toxicology of Metals. Handbook of Experimental Pharmacology, edited by R. A. Goyer and M. G. Cherian. New York: Springer-Verlag, 1995, vol. 115, p. 163-187.
14. Murer, H., and J. Biber. Renal tubular phosphate transport. Cellular mechanisms. In: The Kidney: Physiology and Pathophysiology (2nd ed.), edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, p. 2481-2509.
15. Piscator, M. The nephropathy of chronic cadmium poisoning. In: Cadmium. Handbook of Experimental Pharmacology, edited by E. C. Foulkes. New York: Springer-Verlag, 1986, vol. 80, p. 179-194.
16. +-dependent phosphate transport by group-specific covalent reagents in rat kidney brush border membrane vesicles. Evidence for the involvement of tyrosine and sulfhydryl groups on the interior of the membrane. Arch. Biochem. Biophys. 268: 9-19, 1989.
17. Vacca, C. V., J. D. Hines, and P. W. Hall. The proteinuria of industrial lead intoxication. Environ. Res. 41: 440-446, 1986.
18. +/phosphate cotransporter (NaPi-3) expressed in Xenopus oocytes by intracellular calcium and protein kinase C. Cell. Physiol. Biochem. In press.
19. Waldegger, S., F. Schmidt, T. Herzer, E. Gulbins, A. Schuster, J. Biber, D. Markovich, H. Murer, A. E. Busch, and F. Lang. Heavy metal mediated inhibition of rBAT induced amino acid transport. Kidney Int. 47: 1677-1681, 1995.
20. + pump is permeable to proton. Am. J. Physiol. 268 (Cell Physiol. 37): C590-C595, 1995.
21. Wilks, M. F., E. N. Kwizera, and P. H. Bach. Assessment of heavy metal nephrotoxicity in vitro using isolated rat glomeruli and proximal tubular fragments. Renal Physiol. Biochem. 13: 275-284, 1990.