Apoptosis of hair follicle cells during doxorubicin-induced alopecia in rats

Laboratory Investigation

Volumn 75, Issue 4, 1996, Pages 601-609

  Cece, Raffaele ^a   Cazzaniga, Sara ^b   Morelli, Daniele ^b   Sfondrini, Lucia ^b   Bignotto, Monica ^a   Ménard, Sylvie ^b   Colnaghi, Maria I ^b   Balsari, Andrea ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN;

ALOPECIA; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL ULTRASTRUCTURE; HAIR FOLLICLE; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MICROSCOPY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ALOPECIA; ANIMALS; APOPTOSIS; DEOXYRIBONUCLEASES; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; DOXORUBICIN; FEMALE; HAIR FOLLICLE; HISTOCYTOCHEMISTRY; MICROSCOPY, ELECTRON; RATS;

EID: 0029911278     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Anilkumar TV, Sarraf CE, Hunt T, and Alison MR (1992). The nature of cytotoxic drug-induced cell death in murine intestinal crypts. Br J Cancer 65:552-558.
2. Balsari AL, Morelli D, Ménard S, Veronesi U, and Colnaghi MI (1994). Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies. FASEB J 8:226-230.
3. Cline BW (1984). Prevention of chemotherapy-induced alopecia: A review of the literature. Cancer Nursing 7:221-228.
4. Dean JC, Salmon SE, and Griffith KS (1979). Prevention of doxorubicin-induced hair loss with scalp hypothermia. N Engl J Med 301:1427-1429.
5. Demarcq C, Bunch RT, Creswell D, and Eastman A (1994). The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells. Cell Growth Differ 5:983-993.
6. Eastman A (1990). Activation of programmed cell death by anticancer agents: Cisplatin as a model system. Cancer Cells 2:275-280.
7. Gavrieli Y, Sherman Y, and Ben-Sasson SA (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
8. Goldberg MT, Tackaberry LE, Hardy MH, and Noseworthy JH (1990). Nuclear aberrations in hair follicle cells of patients receiving cyclophosphamide. Arch Toxicol 64:116-121.
9. Hardy MH, Tackaberry LE, and Goldberg MT (1991). A new type of lesion associated with severe fur damage in Canadian ranch foxes and an investigation of possible causes. Can J Vet Res 55:71-75.
10. Hussein AM, Jimenez JJ, McCall CA, and Yunis AA (1990). Protection from chemotherapy-induced alopecia in a rat model. Science 249:1564-1566.
11. Jimenez JJ, Wong GHW, and Yunis AA (1991). Interleukin 1 protects from cytosine arabinoside-induced alopecia in the rat model. FASEB J 5:2456-2458.
12. 3. Cancer Res 52:5123-5125.
13. Kligman AM (1959). The human hair cycle. J Invest Dermatol 33:307-316.
14. Konopa J (1988). G2 block induced by DNA crosslinking agents and its possible consequences. Biochem Pharmacol 37:2303-2309.
15. Montagna W and Parakkal PF (1974). The structure and function of skin. New York: Aacademic Press.
16. Pinkus H (1978). Epithelial-mesodermal interaction in normal hair growth, alopecia, and neoplasia. J Dermatol 5:93-101.
17. Polakowska RR, Piacentini M, Bartlett R, Goldsmith LA, and Haake AR (1994). Apoptosis in human skin development: Morphogenesis, periderm, and stem cells. Dev Dyn 199:176-188.
18. Potten CS (1985). Cell death (apoptosis) in hair follicles and sequent changes in the width of hairs after irradiation growing follicles. Int J Radiat Biol 48:349-360.
19. Skladanowski A and Konopa J (1993). Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumor cells. Biochem Pharmacol 46:375-382.
20. Thakkar NS and Potten CS (1992). Abrogation of adriamycin toxicity in vivo by cycloheximide. Biochem Pharmacol 43:1683-1691.
21. Van Scoot EJ and Ekel TM (1958). Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecia scalp. J Invest Dermatol 31:281-287.