Human immunodeficiency virus-1 (HIV-1) gp120 superantigen-binding serum antibodies: A host factor in homosexual HIV-1 transmission

Journal of Clinical Investigation

Volumn 98, Issue 8, 1996, Pages 1794-1801

  Townsley Fuchs, Janet ^a   Kam, Lawrence ^a   Fairhurst, Rick ^b   Gange, Stephen J ^c   Goodglick, Lee ^a   Giorgi, Janis V ^b   Sidell, Neil ^a   Detels, Roger ^b   Braun, Jonathan ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

AIDS; disease transmission; immunoglobulin; superantigen; VH3

Indexed keywords

GLYCOPROTEIN GP 120; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HOMOSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RESISTANCE; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; SEROCONVERSION; SEXUAL BEHAVIOR; VIRUS TRANSMISSION;

EID: 0029911107     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118979     Document Type: Article

References (50)

1. May, R.M., R.M. Anderson, and S.M. Blower. 1989. The epidemiology and transmission dynamics of HIV-AIDS. Daedalus (Boston). 118:163-191.
2. Levy, J.A. 1993. Pathogenesis of HIV infection. Microbiol. Rev. 57:183-215.
3. Miller, C.J., J.R. McGhee, and M.B. Gardner. 1992. Biology of disease. Mucosal immunity, HIV transmission, and AIDS. Lab. Invest. 68:129-145.
4. Rutherford, G.W. 1994. Long term survival in HIV-1 infection. Br. Med. J. 309:283-284.
5. Lee, T., H.W. Sheppard, M. Reis, D. Dondero, D. Osmond, and M.P. Busch. 1994. Circulating HIV-1-infected cell burden from seroconversion to AIDS: importance of postseroconversion viral load on disease course. J. AIDS. 7:381-388.
6. Pantaleo, G., J.F. Demarest, H. Soudeyns, C. Graziosi, F. Denis, J.W. Adelsberger, P. Borrow, M.S. Saag, G.M. Shaw, R.P. Sekaly, and A.S. Fauci. 1994. Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. Nature (Lond.). 370:463-467.
7. Goodglick, L., and J. Braun. 1994. Revenge of the microbes: superantigens of the T and B cell lineage. Am. J. Pathol. 144:623-636.
8. Berberian, L., L. Goodglick, T.J. Kipps, and J. Braun 1993. Immunoglobulin VH3 gene products: natural ligands for HIV gp120. Science (Wash. DC). 261:1588-1591.
9. Berberian, L., J. Shukla, R. Jefferis, and J. Braun. 1994. Effects of HIV infection on VH3 (D12 idiotope) B cells in vivo. J. AIDS. 7:641-646.
10. Berberian, L., Y. Valles-Ayoub, N. Sun, O. Martinez-Maza, and J. Braun. 1991. A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest. Blood. 78:175-179.
11. Silverman, G.J. 1994. Superantigens and the spectrum of unconventional B-cell antigens. Immunologist. 2:51-57.
12. Pascual, V.C., and J.D. Capra. 1991. B-cell superantigens. Curr. Biol. 1: 315-317.
13. Goodglick, L., N. Zevit, M.S. Neshat, and J. Braun. 1995. Mapping the immunoglobulin superantigen binding site of HIV-1 gp120. J. Immunol. 155: 5151-5159.
14. Zouali, M. B-cell superantigens: implications for selection of the human antibody repertoire. 1995. Immunol. Today. 16:399-405.
15. Pantaleo, G., C. Graziosi, and A.S. Fauci. 1993. The immunopathogenesis of human immunodeficiency virus infection. N. Engl. J. Med. 328:327-335.
16. Joling, P.L., J. Bakker, J.A.G. Van Strijp, T. Meerloo, L. De Graaf, M.E.M. Dekker, J. Goudsmit, J. Verhoef, and H.-J. Schuurman. 1993. Binding of human immunodeficiency virus type-1 to follicular dendritic cells in vitro is complement dependent. J. Immunol. 150:1065-1073.
17. Thieblemont, N., N. Haeffner-Cavailllon, L. Weiss, F. Maillet, and M.D. Kazatchkine. 1993. Complement activation by gp160 glycoprotein of HIV-1. AIDS Res. Hum. Retroviruses. 9:229-233.
18. Süsal, C., M. Kirschfink, M. Kröpelin, V. Daniel, and G. Opelz. 1994. Complement activation by recombinant HIV-1 glycoprotein gp120. J. Immunol. 152:6028-6034.
19. Saarloos, M.-N., T.F. Lint, and G.T. Spear. 1995. Efficacy of HIV-specific and 'antibody-independent' mechanisms for complement activation by HIV-infected cells. Clin. Exp. Immunol. 99:189-195.
20. Kozlowski, P.A., K.P. Black, L. Shen, and S. Jackson. 1995. High prevalence of serum IgA HIV-1 infection-enhancing antibodies in infected individuals. Masking by IgG. J. Immunol. 154:6163-6173.
21. Burke, D.S. 1992. Human HIV vaccine trials: does antibody-dependent enhancement pose a genuine risk? Perspect. Biol. Med. 35:511-530.
22. Jiang, S., K. Lin, and A.R. Neurath. 1991. Enhancement of human immunodeficiency virus type 1 infection by antisera to peptides from the envelope glycoproteins gp120/gp41. J. Exp. Med. 174:1557-1563.
23. Saxon, A., B. Keld, J. Braun, A. Dotson, and N. Sidell. 1993. Longterm administration of 13-cis retinoic acid in common variable immunodeficiency. Circulating IL-6 levels, B cell surface molecule display, and in vitro and in vivo B cell antibody production. Immunology. 80:477-487.
24. Kaslow, R.A., D.G. Ostrow, R. Detels, J.P. Phair, B.F. Polk, and C.R. Rinaldo. The Multicenter AIDS Cohort Study: rationale, organization, and selected characterstics of participants. Am. J. Epidermiol. 126:310-318.
25. Detels, R., Z. Liu, K. Hennessey, J. Kan, B. Visscher, J.M.G. Taylor, D.R. Hoover, C.R. Rinaldo, J.P. Phair, A.J. Saah, and J.V. Giorgi. 1994. Resistance to HIV-1 infection. J. AIDS. 7:1263-1269.
26. Sasso, E.H., G.J. Silverman, and M. Mannik. 1991 Human IgA and IgG F(ab′)2 that bind to staphylococcal protein A belong to the VHIII subgroup. J. Immunol. 147:1877-1883.
27. Silverman, G.J., M. Sasano, and S.B. Wormsley. 1993. Age-associated changes in binding of human B lymphocytes to a VH3-restricted unconventional bacterial antigen. J. Immunol. 151:5840-5855.
28. Clarke, S.H., L.M. Staudt, J. Kavaler, D. Schwartz, W.U. Gerhard, and M.G. Weigert. 1990. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J. Immunol. 144: 2795-2801.
29. Fish, S., E. Zenowich, M. Fleming, and T. Manser. 1989. Molecular analysis of original antigenic sin. 1. Clonal selection, somatic mutation, and isotype switching during a memory B cell response. J. Exp. Med. 170:1191-1209.
30. Press, J.L., and C.A. Giorgetti. 1993. Molecular and kinetic analysis of an epitope-specilic shift in the B cell memory response to a multideterminant antigen. J. Immunol. 151:1998-2013.
31. Silverman, G.J., and A.H. Lucas. 1991. Variable region diversity in human circulating antibodies specific for the capsular polysaccharide of Haemophilus influenzae type b. Preferential usage of two types of VH3 heavy chains. J. Clin. Invest. 88:911-920.
32. Hillson, J.L., I.R. Oppliger, E.H. Sasso, E.C.B. Milner, and M.H. Wener. 1992. Emerging human B cell repertoire: Influence of developmental stage and interindividual variation. J. Immunol. 149:3741-3752.
33. Stewart, A.K., C. Huang, B.D. Stollar, and R.S. Schwartz, 1993. High-frequency representation of a single VH gene in the expressed human B cell repertoire. J. Exp. Med. 177:409-418.
34. Olee, T., P.- Yang, K.A. Siminovitch, N.J. Olsen, J. Hillson, J. Wu, F. Kozin, D.A. Carson, and P.P. Chen. 1991. Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J. Clin. Invest. 88:193-203.
35. Sasso, E.H., K.W. Van Dijk, A. Bull, S.M. Van Der Maarel, and E.C.B. Milner. 1992. VH genes in tandem array comprise a repeated germLine motif. J. Immunol. 149:1230-1236.
36. Detels, R., D. Mann, M. Carrington, K. Hennessy, Z. Wu, K.F. Hirji, D. Wiley, B.R. Visscher, and J.V. Giorgi. 1996. Resistance to HIV-1 infection may he genetically mediated. AIDS. In press.
37. Lederman, M.M., J.B. Jackson, B.L. Kroner, G.C.I. White, M.E. Eyster, L.M. Aledort, M.W. Hilgartner, C.M. Kessler, A.R. Cohen, K.P. Kiger, and J.J. Goedert. 1995. Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs. J. Infect. Dis. 172:228-231.
38. Martas, M.L., K. Van Ro, M. Otsyula, C.J. Miller, D.R. Canfield, N.C. Pedersen, and M.B. McChesney. 1995. Viral factors determine progression to AIDS in simian immunodeficiency virus-infected newborn rhesus macaques. J. Virol. 69:4198-4205.
39. Miller, C.J., J.R. McGhee, and M.B. Gardner. 1992. Biology of disease. Mucosal immunity, HIV transmission, and AIDS. Lab. Invest. 68:129-145.
40. Law, C.L., M. Qassim, A.L. Cunningham, B. Mulhall, and J.M. Grierson. 1992. Nonspecific proctitis: association with human immunodeficiency virus infection in homosexual men. J. Infect. Dis. 165:150-154.
41. Torian, L.V., I.B. Weisfuse, H.A. Makki, D.A. Benson, L.M. DiCamillo, and F.E. Toribio. 1995. Increasing HIV-1 seroprevalence associated with genital ulcer disease. New York City, 1990-1992. AIDS. 9:177-181.
42. Koziol, D.E., A.J. Saah, N. Odaka, and A. Munoz. 1993. A comparison of risk factors for human immunodeficiency virus and hepatitis B virus infections in homosexual men. Ann. Epidemiol. 3:434-441.
43. Casali, P., and A.L. Notkins. 1989. Probing the human B-cell repertoire with EBV: Polyreactive antibodies and CD5+ B lymphocytes. Annu. Rev. Immunol. 7:513-535.
44. Greenspan, N.S., and L.J.N. Cooper. 1995. Complementarity, specificity, and the nature of epitopes and paratopes in multivalent interactions. Immunol. Today. 16:226-230.
45. Grandien, A., R. Fucs, A. Nobrega, J. Andersson, and A. Coutinho. 1994. Negative selection of multireactive B cell clones in normal adult mice. Eur. J. Immunol. 24:1345-1352.
46. Zolla-Pazner, S., and M.K. Gorny. 1992. Passive immunization for the prevention and treatment of HIV infection. AIDS. 6:1235-1247.
47. Robert-Guroff, M., E. Roilides, R. Muldoon, D. Venzon, R. Husson, D. Marshall, R.C. Gallo, and P.A. Pizzo. 1993. Human immunodeficiency virus (HIV) type 1 strain MN neutralizing antibody in HIV-infected children: correlation with clinical status and prognostic value. J. Infect. Dis. 167:538-546.
48. Emini, E.A., W.A. Schleif, J.H. Nunberg, A.J. Conley, Y. Eda, S. Tokiyoshi, S.D. Putney, S. Matsushita, K.E. Cobb, C.M. Jett et al. 1992. Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody. Nature (Lond.). 355:728-730.
49. Prince, A.M., H. Reesink, and D. Pascual. 1991. Prevention of HIV infection by passive immunization with HIV immunoglobulin. AIDS Res. Hum. Retroviruses. 7:971-973.
50. Burton, D.R., J. Pyati, R. Koduri, S.J. Sharp, G.B. Thornton, P.W.H. Parren, L.S.W. Sawyer, R.M. Hendry, N. Dunlop, P.L. Nara et al. 1994. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monodlonal antibody. Science (Wash. DC). 266:1024-1027.