Rheumatic disease patients,pronee to Sjogren's syndrome and/or lymphoma, mount an antibody response to BHRF1. The Epstein-Barr viral homologue of BCL-2

British Journal of Rheumatology

Volumn 35, Issue 11, 1996, Pages 1075-1081

  Newkirk, M M ^a   Shiroky, J B ^a   Johnson, N ^a   Danoff, D ^a   Isenberg, D A ^b   Shustik, C ^a   Pearson, G R ^c  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

BMRF1; Rheumatoid arthritis; Systemic lupus erythematosus

Indexed keywords

VIRUS ANTIBODY; VIRUS ANTIGEN;

ADULT; ANTIBODY DETECTION; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EPSTEIN BARR VIRUS; HUMAN; LYMPHOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, VIRAL; ANTIBODY FORMATION; BURKITT LYMPHOMA; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; MALE; MIDDLE AGED; RHEUMATIC DISEASES; SJOGREN'S SYNDROME; VIRAL PROTEINS;

EID: 0029910576     PISSN: 02637103     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Fox RI, Pearson G, Vaughan JD. Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. J Immunol 1986;137:3162-8.
2. Kitagawa H, Iho S, Yokochi T, Hoshino T. Detection of antibodies to the Epstein-Barr virus nuclear antigens in the sera from patients with systemic lupus erythematosus. Immunol Lett 1988;17:249-52.
3. Pflugfelder SC, Crouse CA, Monroy D, Yen M, Rowe M, Atherton SS. Epstein-Barr virus and the lacrimal gland pathology of Sj̈gren's syndrome. Am J Pathol 1993;143:49-64.
4. Calabresse LH, Wilke WS, Perkins AD, Tubbs RR. Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjögren's syndrome. Arthritis Rheum 1989;32:1453-7.
5. Ngou J, Segondy M, Seigneurin JM, Graafland H. Antibody responses against polypeptide components of Epstein-Barr virus-induced early diffuse antigen in patients with connective tissue diseases. J Med Virol 1990;32:39-46.
6. Inoue N, Harada S, Miyasaka N, Oya A, Yanagi K. Analysis of antibody titers to Epstein-Barr virus nuclear antigens in sera of patients with Sjögren's syndrome and with rheumatoid arthritis. J Infect Dis 1991;164:22-8.
7. Mariette X, Gozlan J, Clerc D, Bisson M, Morinet F. Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjögren's syndrome. Am J Med 1991;90:286-94.
8. Deacon EM, Matthews JB, Potts AJC, Hamburger J, Bevan IS, Young LS. Detection of Epstein-Barr virus antigens and DNA in major and minor salivary glands using immunocytochemistry and polymerase chain reaction: possible relationship with Sjögren's syndrome. J Pathol 1991;163:351-60.
9. Youinou P, Buisson M, Berthelot JM et al. Anti-Epstein-Barr virus-nuclear antigen-1, -2A and -2B antibodies in rheumatoid arthritis patients and their relatives. Autoimmunity 1992;13:225-31.
10. Sumida T, Yonaha F, Maeda T et al. Expression of sequences homologous to HTLV-I tax gene in the labial salivary glands of Japanese patients with Sjögren's syndrome. Arthritis Rheum 1994;37:545-50.
11. Ferraro A, Newkirk MM. Correlation of anti-cytomegalovirus antibodies and rheumatoid factors in the serum of patients with rheumatoid arthritis. Clin Exp Immunol 1993;92:425-31.
12. Tateishi M, Saito I, Yamamoto K, Miyasaka N. Spontaneous production of Epstein-Barr virus by B lymphoblastoid cell lines obtained from patients with Sjögren's syndrome. Arthritis Rheum 1993;36:827-35.
13. Mariette X, Agbalika F, Daniel MT et al. Detection of human T lymphotropic virus type I tax gene in salivary gland epithelium from two patients with Sjögren's syndrome. Arthritis Rheum 1993;36:1423-8.
14. Newkirk MM, Watanabe Duffy KN, Leclerc J, Lambert N, Shiroky JB. Detection of cytomegalovirus, Epstein-Barr virus and herpes virus-6 in patients with rheumatoid arthritis with or without Sjögren's syndrome. Br J Rheumatol 1994;33:317-22.
15. Pearson GR, Luka J, Petti L et al. Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex. Virology 1987;160:151-61.
16. Henderson S, Huan D, Rowe M, Dawson C, Johnson G, Rickinson A. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc Natl Acad Sci USA 1993;90:8479-83.
17. Tsujimoto Y, Croce CM. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 1986;83:5214-8.
18. Kiehl A, Dorsky DI. Cooperation of EBV DNA polymerase and EA-D (BMRF1) in vitro and colocalization in nuclei of infected cells. Virology 1991;184:330-40.
19. Tsurumi T. Purification and characterization of the DNA-binding activity of the Epstein-Barr virus DNA polymerase accessory protein BMRF1 gene products, as expressed in insect cells by using the Baculovirus system. J Virol 1993;67:1682-7.
20. Quinlivan EB, Holley-Guthrie EA, Norris M, Gutsch D, Bachenheimer SL, Kennedy SC. Direct BRLF1 binding is required for cooperative BZLF1/BRLF1 activation of the Epstein-Barr virus early promoter, BMRF1. Nucleic Acids Res 1993;21:1999-2007.
21. Venables PJW, Teo CG, Baboonian C, Griffin BE, Hughes RA, Maini RN. Persistence of Epstein-Barr virus in salivary gland biopsies from healthy individuals and patients with Sjögren's syndrome. Clin Exp Immunol 1989;75:359-64.
22. Kassan S, Thomas T, Moutsopoulos H et al. Increased risk of lymphoma in sicca syndrome. Ann Intern Med 1978;89:888-92.
23. Symmons D. Neoplasms of the immune system in rheumatoid arthritis. Am J Med 1986;78:22-8.
24. Talal N, Dauphinee MJ. Lymphoproliferation and lymphoid malignancy in Sjögren's syndrome. In: Andrianakos A, Kappou I, Mavrikakis M, Moutsopoulos HM, eds. Eurorheumatology. Athens: Tagas and Son Press, 1987:153-4.
25. Janin A, Morel P, Quiquandon I et al. Non-Hodgkin's lymphoma and Sjögren's syndrome. An immunopathological study of 113 patients. Clin Exp Rheumatol 1992;10:565-70.
26. Youinou P, Mackenzie LE, Lamour A, Mageed RA, Lydyard PM. Human CD5-positive B cells in lymphoid malignancy and connective tissue diseases. Eur J Clin Invest 1993;23:139-50.
27. Adachi M, Cossman J, Longo D, Croce CM, Tsujimoto Y. Variant translocation of the bcl-2 gene to immunoglobulin lambda light chain in chronic lymphocytic leukemia. Proc Natl Acad Sci 1989;86:2771-4.
28. Strasser A, Whittingham S, Vaux DL et al. Enforced Bcl-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 1991;88:8661-5.
29. Pothen S, Cao T, Smith R, Levine PH, Levine A, Pearson GR. Identification of T- and B-cell epitopes associated with a restricted component of the Epstein-Barr virus-induced early antigen complex. Int J Cancer 1993;53:199-204.
30. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987. Revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
31. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
32. Vitali C, Bombardieri S, Moutsopoulos HM et al. Preliminary criteria for the classification of Sjögren's syndrome. Arthritis Rheum 1993;36:340-7.
33. Luka J, Chase RC, Pearson GR. A sensitive enzyme-linked immunosorbent assay (ELISA) against the major EBV-associated antigens. I. Correlation between ELISA and immunofluorescence titers using purified antigens. J Immunol Methods 1984;67:145-56.
34. Shiroky J, Watanabe-Duffy K, Leclerc J, Haegert DG, Newkirk MM. Pitfalls in linking the detection of viral genomes to the pathogenesis of proliferative disorders - the Herpes family viruses and lymphoproliferative disorders. Immunol Infect Dis 1992;2:287-91.
35. Johnson NA, Watts C, Newkirk MM. Epstein-Barr and cytomegalo viral lytic cycle proteins in saliva and peripheral blood of rheumatic disease patients, a link to Sjögren's syndrome. Submitted.
36. Luka J, Deep ZE, Hartmann DP, Jenson B, Pearson GP. Detection of antigens associated with Epstein-Barr virus replication in extracts from biopsy specimens of nasopharyngeal carcinomas. J Natl Cancer Inst 1988;80:1164-7.
37. Katz BZ, Saini U. Presence of the diffuse early antigen of Epstein-Barr virus in lymphomas and lymphoproliferative disorders. Am J Pathol 1992;140:1247-54.
38. Becker Y, Tabor C, Asher Y. Epstein-Barr virus BHRF1 gene but not the cellular protooncogene bcl-2 is expressed in ataxia-telangiectasia lymphoblastoid lines. Virus Genes 1991;5:33-45.
39. Kocache MM, Pearson GR. Protein kinase activity associated with a cell cycle regulated membrane-bound Epstein-Barr virus-induced early antigen. Intervirology 1990;31:1-13.
40. Newkirk MM, Watanabe Duffy KN, Paleckova A et al. Herpes viruses in multicase families with rheumatoid arthritis. J Rheumatol 1995;22:2055-61.
41. Dawson CW, Eliopoulos AG, Dawson J, Young LS. BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation. Oncogene 1995;10:69-77.
42. Marchini A, Tomkinson B, Cohen JI, Kieff E. BHRF1, the Epstein-Barr virus gene with homology to bcl-2, is dispensable for B-lymphocyte transformation and virus replication. J Virol 1991;65:5991-6000.
43. Lee MA, Yates JL. BHRF1 or Epstein-Barr virus, which is homologous to human proto-oncogene bcl2, is not essential for transformation of B cells or for virus replication in vitro. J Virol 1992;66:1899-906.
44. 6-methylguanine-DNA in primary Sjögren's syndrome patients predisposed to lymphoma. Ann Rheum Dis 1995;54:229-32.
45. Tarodi B, Subramanian T, Chinnadura G. Epstein-Barr virus BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection. Virology 1994;201:404-7.
46. Kamel OW, vande Rijn M, Weiss LM et al. Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. N Engl J Med 1993;328:1317-21.
47. Lioté F, Pertuiset E, Cochand-Priollet B et al. Methotrexate related B lymphoproliferative disease in a patient with rheumatoid arthritis. Role of Epstein-Barr virus infection. J Rheumatol 1995;22:1174-8.
48. Ferraccioli GF, Casatta L, Bartoli E et al. Epstein-Barr virus-associated Hodgkin's lymphoma in a rheumatoid arthritis patient treated with methotrexate and cyclosporin A. Arthritis Rheum 1995;38:867-8.