Cytotoxic and genotoxic effects of cleistanthin B in normal and tumour cells

Mutagenesis

Volumn 11, Issue 6, 1996, Pages 553-557

  Prabhakaran, Chhalliyil ^a   Kumar, Pradheep ^a   Panneerselvam, Natarajan ^a   Rajesh, Sunderasan ^a   Shanmugam, Govindaswamy ^a  

^a MADURAI KAMARAJ UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA FRAGMENT; PLANT TOXIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CHO CELL; CHROMATID ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DEGRADATION; DNA STRAND BREAKAGE; GENOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MICRONUCLEUS TEST; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; TUMOR CELL;

ANIMALIA; CLEISTANTHUS; CLEISTANTHUS COLLINUS; CRICETINAE; CRICETULUS GRISEUS;

EID: 0029910503     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/11.6.553     Document Type: Article

References (16)

1. Annapoorni, K.S. and Damodaran, C. (1986) Novel inhibition of LDH isoenzymes by Cleistanthus collinus toxins. Current Sci., 55, 854-856.
2. Bhakuni, D.S., Dhar, M.L., Dhar, M.M., Dhawan, B.N. and Mehrota, B.N. (1969) Screening of Indian plants for biological activity part II. Indian J. Exp. Biol., 7, 250.
3. Chopra, R.N., Badhwar, R.C. and Gosh, S. (1965) Poisonous Plants of India. Vol. 2. Indian Council of Agricultural Research, New Delhi.
4. Evans, H.J., Kilbey, B.J., Legator, M., Nichols, W. and Ramel, C., (1984) Handbook of Mutagenicity Tests Procedures. Elsevier Science Publishers BV, Amsterdam, The Netherlands, pp. 406-428.
5. Fenech, M. and Morley, A. (1985) Measurement of micronuclei in lymphocytes. Mutat. Res., 147, 29-36.
6. Govindachari, T.R., Sathe, S.S., Viswanathan, N., Pai, B.R. and Srinivasan, M. (1969) Chemical constituents of Cleistanthus collinus. Tetrahedron, 25, 2815-2821.
7. Herrmann, M., Lorenz, H.M., Voll, R., Grunke, M., Woith, W. and Kalden, J.R. (1994) A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res., 22, 5506-5507.
8. Ishidate, M. Jr, Harnois, M.C. and Sofuni, T. (1988) A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 195, 151-213.
9. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Immunol. Meth., 65, 55-63.
10. Nagaraj, S. (1987) Cardiac toxicity of Oduvan thalai (Cleistanthus collinus) common leaves poisoning in Tamil Nadu (Report of 25 cases). Antiseptic, January, pp. 34-35.
11. Olive, P.L. (1988) The DNA precipitation assay: a rapid and simple method for detecting DNA damage in mammalian cells. Environ. Mol. Mutagen., 11, 487-495.
12. Preston, R.J., Au, W., Bender, M., Brewen, J., Carrano, A., Heddle, J., McFee, A., Wolff, S. and Wasson, J. (1981) Mammalian in vivo and in vitro cytogenetic assays: a report of the US EPA's Gene-Tox Program. Mutat. Res., 87, 143-188.
13. Rao, R.A. and Nair, T.B.(1970) Investigations on induction of neutrophilic granulocytosis and toxicity of cleistanthin - CIBA GO.4350 - A new glycoside from Cleistanthus collinus (Roxb). Pharmacology, 4, 347-358.
14. Rao, R.A. and Nair, T.B. (1971) Effect of cleistanthin, a new glycoside, on experimentally induced Leukopenia in rats and mice. Drug Res., 21, 828.
15. Waldman, T., Lengauer, C., Kinzler, K.W and Vogelstein, B.(1996) Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking P21. Nature, 381, 713-716.
16. Wrasidlo, W., D.S. Johnson and D.L. Boger (1994) Induction of endonudeolytic DNA fragmentation and apoptosis by the Duocarmycins. Bioorg. Med. Chem. Letts., 4, 631-636.