Permeability enhancing effect of oleic acid and its mechanism in human alveolar A549 cells

European Journal of Pharmaceutical Sciences

Volumn 4, Issue 5, 1996, Pages 267-272

  Kobayashi, Shinzo ^a   Kondo, Shuji ^a   Juni, Kazuhiko ^b  

^a SANOFI   (France)

^b JOSAI UNIVERSITY   (Japan)

Author keywords

Alveolar permeability; Calmodulin; In vitro absorption enhancement; Intracellular calcium; Oleic acid; Pulmonary absorption

Indexed keywords

1 (5 CHLORO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1,6 HEXAMETHYLENEDICARBAMIC ACID BIS(CYCLOHEXANONE OXIME) ESTER; 3 [2 [4 (4,4' DIFLUOROBENZHYDRYLIDENE)PIPERIDINO]ETHYL] 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; CALCINEURIN; CALCIUM CHANNEL BLOCKING AGENT; CALMODULIN; CALMODULIN INHIBITOR; COMPOUND 48-80; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NIFEDIPINE; OLEIC ACID; PENETRATION ENHANCING AGENT; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; TAUROCHOLIC ACID; VERAPAMIL;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; DRUG MECHANISM; DRUG PENETRATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL; MEMBRANE PERMEABILITY; PRIORITY JOURNAL;

EID: 0029910493     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(96)00169-8     Document Type: Article

References (3)

1. Bhat, M., Toledo-Velasques, D., Wang, L.Y., Malanga, C.J. Ma, J.K.H. and Rojanasakul, Y. (1993) Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium. Pharm. Res. 10, 991-997.
2. Byron, P.R. (1990) Determinants of drug and polypeptide bioavailability from aerosols delivered to the lung. Adv. Drug Deliv. Rev. 5, 107-132.
3. Chang, C.F., Gutierrez, L.M., Mundina-Weilenmann, C. and Hosey, M.M. (1991) Dihydropydirine-sensitive calcium channels from skeletal muscle. II. Functional effects of differential phosphorylation of channel subunits. J. Biol. Chem. 266, 16395-16400.