5'-Dithiophosphoryl deoxyoligonucleotides: Synthesis and biological studies

Journal of the American Chemical Society

Volumn 118, Issue 40, 1996, Pages 9562-9566

  Seeberger, Peter H ^b,c   Jorgensen, Pia N ^b,d   Bankaitis Davis, Danute M ^b   Beaton, Graham ^b   Caruthers, Marvin H ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b AMGEN INC   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE;

ARTICLE; DRUG STABILITY; DRUG SYNTHESIS;

EID: 0029909524     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja961189a     Document Type: Article

References (23)

1. This is paper 46 in a series on nucleotide chemistry. Paper 45 is Kofoed, T.; Caruthers, M. H., Tetrahedron Lett. 1996 in press. This research was supported by the National Institutes of Health (Grant GM25680) and Amgen Inc. Abbreviations: T, thymine; TLC, thin layer chromatography; PAGE, polyacrylamide gel electrophoresis; TEAB, triethylammonium bicarbonate; HPLC, high performance liquid chromatography; DTT, dithiothreitol; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DMF, N,N-dimethyl-formamide; Fmol, 9-fluorenemethanol, DPCP, diphenylchlorophosphate; DMT, dimethoxytrityl; CPG, controlled pore glass.
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