Insulin and glucagon responses to provocation with glucose and arginine in prepubertal children with thalassemia major before and after long-term blood transfusion

Journal of Tropical Pediatrics

Volumn 42, Issue 5, 1996, Pages 291-296

  Soliman, Ashraf T ^a,b   El Banna, Nagwa ^b   Alsalmi, Issa ^b   Asfour, Maurice ^b  

^a ALEXANDRIA UNIVERSITY   (Egypt)

^b ROYAL HOSPITAL   (Oman)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CLONIDINE; GLUCAGON; GLUCOSE; GROWTH HORMONE; INSULIN; SOMATOMEDIN C;

ARTICLE; BLOOD TRANSFUSION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; HYPERGLUCAGONEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; IRON CHELATION; IRON OVERLOAD; LONG TERM CARE; ORAL GLUCOSE TOLERANCE TEST; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PREPUBERTY; PRESCHOOL CHILD; PROVOCATION TEST; QUALITY OF LIFE; THALASSEMIA MAJOR;

EID: 0029908886     PISSN: 01426338     EISSN: None     Source Type: Journal    
DOI: 10.1093/tropej/42.5.291     Document Type: Article

References (38)

1. Ellis JT, Schulman I, Smith CH. Generalized siderosis with fibrosis of liver and pancreas in Cooley's (Mediterranean) anemia. With observations on the pathogenesis of the siderosis and fibrosis. Am J Path 1953; 30: 287-309.
2. Saudek CD, Hemm RM, Peterson CM. Abnormal glucose tolerance in B-thalassemia major. Metabolism 1977; 26: 43-52.
3. Lassman MN, Genel M, Wise JK, Hendler R, Feiig P. Carbohydrate homeostasis and pancreatic islet cell function in thalassemia. Ann Intern Med 1974; 80: 65-9.
4. McIntosh N. Endocrinopathy in thalassemia major. Arch Dis Childh 1976; 51: 195-201.
5. Flynn DM, Fairney A, Jackson D, Clayton BE. Hormonal changes in thalassemia major. Arch Dis Childh 1976; 51: 828-36.
6. Zuppinger K, Molinari B, Hirt A. Increased risk of diabetes mellitus in beta-thalassemia major due to iron overload. Helv Paediat Acta 1979; 34: 197-207.
7. Del Prato S, Tiengo A. Diabetes secondary to acquired diseases of the pancreas. In: Alberti KGMM, Defronzo RA, Keen H, Zimmet P, eds, International Textbook of Diabetes Mellitus, Vol 1. Chichester: John Wiley & Sons, 1992: 197-220.
8. Costin G, Kogut M, Hyman C, Ortega J. Carbohydrate metabolism and pancreatic islet-cell function in thalassemia major. Diabetes 1977; 26: 230-40.
9. Dandona P, Hussain MAM, Varghese Z, Politis D, Flynn DM, Hoffbrand AV. Insulin resistance and iron overload. Ann Clin Biochem 1983; 20: 77-9.
10. De Sanctis V, D'Ascola G, Wonke B. The development of diabetes mellitus and chronic disease in long term chelated B-thalassemic patients. Postgraduate Med J, 1986; 62: 831-6.
11. Hecht A, Gershberg H. Diabetes mellitus and primary hypothyroidism. Metabolism 1968; 17: 108-13.
12. De Sanctis V, Zurlo MG, Sensi E, Boffa C, Cavallo L, Di Gregorio F. Insulin dependent diabetes in thalassemia. Arch Dis Childh 1988; 63: 58-62.
13. Toccafondi R, Maioli M, Meloni T. Plasma insulin response to oral carbohydrate in Cooley's anemia. Riv Clin Med 1970; 70: 96-100.
14. Lassman MN, O'Brien RT, Pearson HA, et al. Endocrine evaluation in thalassemia major. Ann NY Acad Sci 1974; 232: 226-31.
15. Merkel PA, Simonson DC, Amiel SA, et al. Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N Engl J Med 1988; 318: 809-14.
16. Kuo B, Zaino A, Roginsky MS. Endocrine function in thalassemia major. J Clin Endocrinol 1968; 28: 805-11.
17. Toccafondi R, Maioli M, Meloni T. The plasma HGH and 11-OHCS response to insulin induced hypoglycemia in children affected by thalassemia major. Riv Clin Med 1970; 70: 102-6.
18. DeFronzo RA, Bonadonna RC, Ferranninni E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 1992; 15: 318-68.
19. Consoli A, Nurjhan N, Reilly JJ, Bier DM, Gerich JE. Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. J Clin Invest 1990; 86: 2038-45.
20. Reaven GM, Chen Y-DI, Golay A, Swislocki ALM, Jaspan JB. Documentation of hyperglucagonemia throughout the day in non obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987; 64: 106-10.
21. Cosoli A, Nurjhan N, Capani F, Gerich JE. Predominant role of gluconeogenesis m increased hepatic glucose production in NIDDM. Diabetes 1989; 38: 550-7.
22. Barron AD, Schaeffer L, Shragg P, Kolterman OG. Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetes. Diabetes 1987; 36: 274-83.
23. DeFronzo RA, Ferrannini E, Simonson DC. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: Contributions of excessive hepatic glucose production and impaired tissue glucose-uptake. Metabolism 1989; 4: 387-95.
24. Campbell DG, Mandarino LJ, Gerich JE. Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in noninsulin-dependent diabetes mellitus. Metabolism 1988; 37: 15-22.
25. Alberti KGMM, Christensen NJ, Iversen J, Orskov H. Role of glucagon and other hormones in the development of diabetic ketoacidosis. Lancet 1975; i: 1307-11.
26. Passarillo N. Role of alpha and beta-cells in the impaired glucose tolerance of thalassemic subjects. Diabetes Metab 1987; 13: 436-40.
27. Nelson LR, Baldus WP, Rubenstein AH, Gov LW, Service FJ. Pancreatic A-cell function in diabetic hemochromatic subjects. J Clin Endocrinol Metab 1979; 48: 412-5.
28. Tanner JM, Goldstein H, Whitehouse RH. Standards for children's height at ages 2-9 years allowing for height of parents. Arch Dis Childh 1970; 45: 755-62.
29. Greulich WW, Pyle SJ. Radiographic atlas of skeletal development of the hand and wrist Palo Alto: Stanford University Press, 1973.
30. Vinik AI. Insulin secretion in chronic pancreatitis. In Tiengo A, Alberti KGMMM, Del Prato S, Vrancis M, eds, Diabetes secondary to pancreatopathy. Amsterdam: Excerpta Medica, 1988: 35-50.
31. Dmochowski K, Finegood DT, Francombe W, Tyler B, Zinman B. Factors determining glucose tolerance in patients with thalassemia major. J Clin Endocrinol Metab 1993; 77: 478-83.
32. Brianda S, Maioli M, Frulio T. The euglycemic clamp in patients with thalassemia intermedia. Horm Metab Res 1987; 19: 319-22.
33. Gerold MG. Chemistry and functions of the thyroid, pancreas and adrenal. In: Martin DW, Mayes PA, Rodwell VW, eds, Harper's review of biochemistry, 18th ed. Los Altos: Lange Medical Publications, 1981: 468-88.
34. Shehadeh N, Hazani A, Rudolf MC, Peleg I. Neurosecretory dysfunction of growth hormone secretion in thalassemia major. Acta Paediat Scand 1990; 79: 790-5.
35. Pintor C, Cella SG, Manso P, Corda R, Dessi C, Locatelli V, Muller EE. Impaired growth hormone (GH) response to GH-releasing hormone in thalassemia major. J Clin Endocrinol Metab 1986; 62: 263-7.
36. Danesi L, Scacchi M, De-Martin M, Dubini-A, Massaro P, Majolo AT, Evaluation of hypothalamic-pituitary function in patients with thalassemia. J Endocrinol Invest 1992; 15: 177-84.
37. Postel-Vinay-MC, Girot-R, Leger J, Hocquette-JF, McKelvie P. No evidence for a defect in growth hormone binding to liver membranes in thalassemia major. J Clin Endocrinol Metab 1989; 68: 94-8.
38. Brismar K, Fernqvist-Forbes E, Wahren J, Hall K. Effect of insulin on hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-1 in insulin-dependent diabetes. J Clin Endocrinol Metab 1994; 79: 872-8.