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Winslow RM, Vandegriff KD, Intaglietta M: Blood Substitutes: New Challenges. Boston: Birkhauser; 1996. Includes a list of almost all published papers on blood substitutes in 1995. These annual volumes contain reviews of many important scientific and some medical and social issues in blood substitutes research and development.
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Dietz NM, Joyner MJ, Warner MA: Blood substitutes: fluids, drugs, or miracle solutions. Anesth Analg 1996, 82:390-405. Reviews the toxicities and pharmacology of hemoglobin solutions compared with the functional requirements for oxygen carriers in the common clinical indications.
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0029004672
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Review of modified hemoglobin research at Letterman: Attempts to delineate the toxicity of cell-free tetrameric hemoglobin
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Kaufman RJ: Clinical development of perfluorocarbon-based emulsions as red cell substitutes. In Current Issues in Blood Substitute Research: Physiological Basis of Efficacy. Edited by Winslow RM, Vandegriff KD, Intaglietta M. Boston: Birkhauser; 1995:53-75.
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Spence RK, Norcross ED, Constabile J, McCoy S, Cernaianu AC, Alexander JB, Pello MJ, Atabek U, Camishion RC: Perfluorocarbons as blood substitutes: the early years. Experience with Fluosol DA-20% in the 1980s. Artif Cells Blood Substit Immobil Biotechnol 1994, 22:955-963.
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0029050778
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Effects of perfluorocarbon exchange transfusion on reducing myocardial infarct size in a primate model of ischemia-reperfusion injury: A prospective, randomized study
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Premaratne S, Harada RN, Chun P, Suehiro A, McNamara JJ: Effects of perfluorocarbon exchange transfusion on reducing myocardial infarct size in a primate model of ischemia-reperfusion injury: a prospective, randomized study. Surgery 1995, 117:670-676. Results suggest that the beneficial effects of exchange transfusion with perfluorocarbons may be primarily due to hemodilution, as exchange transfusion with emulsion was better than no treatment but not better than exchange with Ringer's lactate.
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Keipert PE: Use of Oxygent™, a perfluorochemical-based oxygen carrier, as an alternative to intraoperative blood transfusion. Artif Cells Blood Substit Immobil Biotechnol 1995, 23:381-394.
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Evaluation of the immunogenicity of polymerized hemoglobin in a rabbit model
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Bleeker WK, Zappeij LM, den Boer PJ, Agterberg JA, Rigter GM, Bakker JC: Evaluation of the immunogenicity of polymerized hemoglobin in a rabbit model. Artif Cells Blood Substit Immobil Biotechnol 1995, 23:461-468.
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Olsen SB, Tang DB, Jackson MR, Gomez ER, Ayala B, Alving BM: Enhancement of platelet deposition by cross-linked hemoglobin in a rat carotid endarterectomy model. Circulation 1996, 93:327-332.
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Hemoglobin-nitric oxide interaction and its implications
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Motterlini R, Vandegriff KD, Winslow RM: Hemoglobin-nitric oxide interaction and its implications. Transfus Med Rev 1996, 10:77-84. Very good review of the mechanisms of hemoglobin's reactions with nitric oxide and how they may affect blood pressure control and peroxidative injury.
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Motterlini, R.1
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Lee R, Neya K, Svizzero TA, Vlahakes GJ: Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions. J Appl Physiol 1995, 79:236-242. This study demonstrates the ability of a polymerized hemoglobin to cause systemic and pulmonary hypertension and increased vascular resistance, which in turn limit oxygen transport. It also shows the instability of polymerized hemoglobin with rapid conversion to methemoglobin.
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J Appl Physiol
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Lee, R.1
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0029411044
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Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects
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Hughes GS, Francome SF, Antal EJ, Adams WJ, Locker FK, Yancey EP, Jacobs EE: Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects. J Lab Clin Med 1995, 126:444-451.
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Hughes, G.S.1
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Jacobs, E.E.7
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27
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0028934323
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Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo
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Balla J, Nath KA, Balla G, Juckett MB, Jacob HS, Vercellotti GM: Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo. Am J Physiol 1995, 268:L321-L327.
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Balla, J.1
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0028809161
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Reaction of human hemoglobin HbAo and two cross-linked derivatives with hydrogen peroxide: Differential behavior of the ferryl intermediate
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Cashon RE, Alayash AI: Reaction of human hemoglobin HbAo and two cross-linked derivatives with hydrogen peroxide: differential behavior of the ferryl intermediate. Arch Biochem Biophys 1995, 316:461-469.
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Motterlini R, Foresti R, Vandegriff K, Intaglietta M, Winslow RM: Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions. Am J Physiol 1995, 269:H648-H655.
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Am J Physiol
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Effects of polymerization on the oxygen carrying and redox properties of diaspirin cross-linked hemoglobin
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Rogers MS, Ryan BB, Cashon RE, Alayash AI: Effects of polymerization on the oxygen carrying and redox properties of diaspirin cross-linked hemoglobin. Biochim Biophys Acta 1995, 1248:135-142.
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Rogers, M.S.1
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Oxyradical generation after resuscitation of hemorrhagic shock with blood or stroma-free hemoglobin solution
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Biro GP, Ou C, Ryan-McFarlane C, Anderson PJ: Oxyradical generation after resuscitation of hemorrhagic shock with blood or stroma-free hemoglobin solution. Artif Cells Blood Substit Immobil Biotechnol 1995, 23:631-645.
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Diaspirin crosslinked hemoglobin (DCLHb™): Absence of increased free radical generation following administration in a rabbit model of renal ischemia and reperfusion
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Princemail J, Detry O, Philippart C, Defraingne, Franssen C, Burhop K, Deby C, Meurisse M, Lamy M: Diaspirin crosslinked hemoglobin (DCLHb™): absence of increased free radical generation following administration in a rabbit model of renal ischemia and reperfusion. Free Radic Biol Med 1995, 19:1-9.
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Princemail, J.1
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Neurotoxicity of hemoglobin in cortical cell culture
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Regan RF, Panter SS: Neurotoxicity of hemoglobin in cortical cell culture. Neurosci Lett 1993, 153:219-222.
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0027944068
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Hemoglobin stimulates mononuclear leukocytes to release interleukin-8 and tumor necrosis factor alpha
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McFaul SJ, Bowman PD, Villa VM, Gutierrez-Ibanez, Johnson M, Smith D: Hemoglobin stimulates mononuclear leukocytes to release interleukin-8 and tumor necrosis factor alpha. Blood 1994, 84:3175-3181.
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0029097034
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Effects of bacterial endotoxin on human cross-linked and native hemoglobins
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Kaca W, Roth RI, Vandegriff KD, Chen GC, Kuypers FA, Winslow RM, Levin J: Effects of bacterial endotoxin on human cross-linked and native hemoglobins. Biochemistry 1994, 34:11176-11185.
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0028131671
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Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity
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Kaca W, Roth RI, Levin J: Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity. J Biol Chem 1994, 269:25078-25084.
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0028203748
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Hemoglobin enhances the production of tissue factor by endothelial cells in response to bacterial endotoxin
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Roth RI: Hemoglobin enhances the production of tissue factor by endothelial cells in response to bacterial endotoxin. Blood 1994, 83:2860-2865.
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Blood
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Su D, Roth RI, Levin J: Hemoglobin enhances the mortality from bacterial endotoxin [abstract #1767]. Blood 1995, 86:445a.
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Hemoglobin based blood substitutes and sepsis
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Griffiths E, Cortes A, Gilbert N, Stevenson P, MacDonald S, Pepper D: Hemoglobin based blood substitutes and sepsis. Lancet 1995, 345:158-160.
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Lancet
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Griffiths, E.1
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40
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0028812732
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Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans
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Hughes GS, Yancey EP, Albrecht R, Locker PK, Francome SF, Orringer EP, Antal EJ, Jacobs EE: Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans. Clin Pharmacol Ther 1995, 58:434-443.
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Hughes, G.S.1
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41
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0029019041
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Yohimbine modulates diaspirin crosslinked hemoglobin induced systemic hemodynamics and regional circulatory effects
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Sharma AC, Gulati A: Yohimbine modulates diaspirin crosslinked hemoglobin induced systemic hemodynamics and regional circulatory effects. Crit Care Med 1995, 23:874-884.
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Sharma, A.C.1
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0029371935
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Renal and systemic-hemodynamic response to isovolemic exchange transfusion with hemoglobin cross-linked with bis(3,5-bromosalicyl) fumarate or albumin
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Matheson-Urbaitis B, Lu YS, Fronticelli C, Bucci E: Renal and systemic-hemodynamic response to isovolemic exchange transfusion with hemoglobin cross-linked with bis(3,5-bromosalicyl) fumarate or albumin. J Lab Clin Med 1995, 126:250-260.
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Resuscitation with diaspirin crosslinked hemoglobin in a pig model of hemorrhagic shock
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Dunlop E, Farrell L, Nigro C, Estep T, Marchand G, Burhop K: Resuscitation with diaspirin crosslinked hemoglobin in a pig model of hemorrhagic shock. Artif Cells Blood Substit Immobil Biotechnol 1995, 23:39-61.
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0029095695
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Comparison of the efficacy of blood and polyethylene glycolhemoglobin in recovery of newborn piglets from hemorrhagic hypotension: Effect on blood pressure, cortical oxygen, and extracellular dopamine in the brain
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Song D, Olano M, Wilson DF, Pastuszko A, Tammela O, Nho K, Shore RGL: Comparison of the efficacy of blood and polyethylene glycolhemoglobin in recovery of newborn piglets from hemorrhagic hypotension: effect on blood pressure, cortical oxygen, and extracellular dopamine in the brain. Transfusion 1995, 35:552-558.
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Song, D.1
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45
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0030039877
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Diaspirin cross-linked hemoglobin is efficacious in gut resuscitation as measured by GI tract optrode
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Frankel HL, Nguyen HB, Shea-Donahue T, Aiton LA, Ratigon J, Malcolm DS: Diaspirin cross-linked hemoglobin is efficacious in gut resuscitation as measured by GI tract optrode. J Trauma 1996, 40:231-240.
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Frankel, H.L.1
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46
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0028828211
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Diaspirin cross-linked hemoglobin does not increase brain oxygen consumption during hypothermic cardiopulmonary bypass in rabbits
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Hindman J, Dexter F, Cutkomp J, Smith T: Diaspirin cross-linked hemoglobin does not increase brain oxygen consumption during hypothermic cardiopulmonary bypass in rabbits. Anesthesiology 1995, 83:1302-1311.
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Hindman, J.1
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47
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0028899898
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Systemic and subcutaneous microvascular oxygen tension in conscious Syrian golden hamsters
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Kerger H, Torres Filho IP, Rivas M, Winslow RM, Intaglietta M: Systemic and subcutaneous microvascular oxygen tension in conscious Syrian golden hamsters. Am J Physiol 1995, 268:H802-H810.
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Am J Physiol
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Kerger, H.1
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48
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0029043204
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Interarterial perfusion of the hindlimb with pyridoxalated hemoglobin polyoxyethylene conjugate solution in anesthetized dogs
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Kida Y, Yamakawa T, Iwasaki S, Furusho N, Kadowaki Y, Iwate S, Iwashita Y, Nishi K: Interarterial perfusion of the hindlimb with pyridoxalated hemoglobin polyoxyethylene conjugate solution in anesthetized dogs. Artif Organs 1995, 19:511-518.
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Kida, Y.1
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49
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Schultz SC, Powell CC, Bernard E, Malcolm D: Diaspirin crosslinked hemoglobin (DCLHb) attenuates bacterial translocation in rats. Artif Cells Blood Substit Immobil Biotechnol 1995, 23:647-664.
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50
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