Fine specificity of anti-Ro(SSA) autoantibodies and clinical manifestations in patients with systemic lupus erythematosus

Journal of Rheumatology

Volumn 23, Issue 11, 1996, Pages 1897-1903

  Zimmermann, Christof ^a   Smolen, Josef S ^d   Graninger, Winfried ^b   Petera, Peter ^a   Fabini, Gustav ^c   Hassfeld, Wolfgang ^a   Höfler, Elisabeth ^a   Steiner, Günter ^a,d  

^a GENERAL HOSPITAL LINZ   (Austria)

^b Department of Rheumatology ^*

^c Institute of Biochemistry   (Switzerland)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

ANTI RO; Nephritis; SLe

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AUTOANTIGENS; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOBLOTTING; IMMUNODIFFUSION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC; SENSITIVITY AND SPECIFICITY; SEROLOGIC TESTS; TRANSCRIPTION FACTORS;

EID: 0029908651     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. van Venrooij WJ, Slobbe RL, Pruijn GJM: Structure and function of La and Ro RNPs. Mol Biol Reports 1993;18:113-9.
2. Wolin SL, Steitz JA: The Ro small cytoplasmic ribonucleoproteins: Identification of the antigenic protein and its binding site on the Ro RNAs. Proc Natl Acad Sci USA 1984;81:1996-2000.
3. Ben-Chetrit E, Chan EKL, Sullivan KF, Tan EM: A 52kD protein is a novel component of the SSA/Ro antigenic particle. J Exp Med 1988;167:1560-71.
4. Kelekar A, Saitta MR, Keene JD: Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD Ro proteins. J Clin Invest 1994;93:1637-44.
5. Boire G, Gendron M, Monast N, Bastin B, Ménard HA: Purification of antigenically intact Ro ribonucleoproteins; biochemical and immunological evidence that the 52-kD protein is not a Ro protein. Clin Exp Immunol 1995;100:489-98.
6. Ben-Chetrit E: The molecular basis of the SSA/Ro antigens and the clinical significance of their autoantibodies. Br J Rheumatol 1993;32:396-402.
7. Boire G, Craft J: Human Ro ribonucleoprotein particles: Characterization of native structure and stable association with the La polypeptide. J Clin Invest 1990;85:1182-90.
8. Slobbe RL, Pluk W, van Venrooij WJ, Pruijn GJM: Ro ribonucleoprotein assembly in vitro. Identification of RNA-protein and protein-protein interactions. J Mol Biol 1992;227:361-6.
9. Boulanger C, Chabot B, Mënard HA, Boire G: Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA. Clin Exp Immunol 1995;99:29-36.
10. Meilof JF, Bantjes I, van Dam AP, Smeenk RJ: The detection of anti-Ro/SS-A and anti-La/SS-B antibodies. A comparison of counterimmunoelectrophoresis with immunoblot, ELISA and RNA-precipitation assays. J Immunol Meth 1990;133:215-26.
11. Ben-Chetrit E, Fox RI, Tan EM: Dissociation of immune responses to the SS-A (Ro) 52-kD and 60-kD polypeptides in systemic lupus erythematosus and Sjögren's syndrome. Arthritis Rheum 1990;33:349-55.
12. Slobbe RL, Pruijn GJM, Damen WGM, van der Kemp JW, van Venrooij WJ: Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these proteins. Clin Exp Immunol 1991;86:99-105.
13. Bozic B, Prujin GJM, Rozman B, van Venrooij WJ: Sera from patients with autoimmune diseases recognize different epitope regions on the 52-kD Ro/SS-A protein. Clin Exp Immunol 1993;94:227-35.
14. López-Longo FJ, Rodriguez-Mahou M, Escalona M. et al: Heterogeneity of the anti-Ro(SSA) response in rheumatic diseases. J Rheumatol 1994;21:1450-6.
15. Reichlin M, Harley JB: ANA subsets in systemic lupus erythematosus. In: Smolen JS, Zielinski CC, eds. Systemic Lupus Erythematosus. Clinical and Experimental Aspects. Berlin: Springer Verlag, 1987:105-23.
16. Buyon JP, Winchester R: Congenital complete heart block. A human model of passively acquired autoimmune injury. Arthritis Rheum 1990;33:609-14.
17. Smolen JS, Morimoto C, Steinberg AD, et al: Systemic lupus erythematosus: Delineation of subpopulations by clinical, serologic, and T cell subset analysis. Am J Med Sci 1985;289:139-46.
18. Tan EM, Cohen AS, Fries JF, et al: The 1982 revised criteria for the classification of SLE. Arthritis Rheum 1982;25:1271-7.
19. Charles PJ, van Venrooj WJ, Maini RN and the Consensus Finding Group for Autoantibodies: The Consensus Workshop for the Detection of Autoantibodies to Intracellular Antigens in Rheumatic Diseases: 1989-1992. Clin Exp Rheumatol 1992;10:507-11.
20. Verheijen R, Salden M, van Venrooij WJ: Protein blotting. In: van Venrooij WJ, Maini RN, eds. Manual of Biological Markers of Disease. Amsterdam: Kluwer, 1993:A4/1-25.
21. Buyon JP, Slade SG, Chan EKL, et al: Effective separation of the 52kD SSA/Ro polypeptide from the 48kD SSB/La polypeptide by altering conditions of polyacrylamide gel electrophoresis. J Immunol Methods 1990;129:207-10.
22. Pruijn GJM, Slobbe RL, van Venrooij WJ: Analysis of protein-RNA interactions within Ro ribonucleoprolein complexes. Nucleic Acids Res 1991;19:5173-80.
23. Steiner G, Hartmuth K, Skriner K, et al: Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. J Clin Invest 1992;90:1061-6.
24. Buyon JP, Slade SG, Reveille JD, Hamel JC, Chan EKL: Antoantibody responses to the "native" 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjögren's syndrome. J Immunol 1994;152:3675-84.
25. Boire G, Lopez-Lungo FJ, Lapointe S, Ménard HA: Sera from patients with autoimmune disease recognize conformational determinants on the 60kD Ro/SSA protein. Arthritis Rheum 1991;34:722-30.
26. Saitta MR, Arnett FC, Keene JD: 60-kDa Ro protein autoepitopes identified using recombinant polypeptides. J Immunol 1994;152:4192-202.
27. Gordon T, Mavrangelos C, McCluskey J: Restricted epitope recognition by precipitin-negative anti-La/SS-B-positive sera. Arthritis Rheum 1992;35:663-6.
28. Tsuzaka K, Fujii T, Akizuki M, et al: Clinical significance of antibodies to native or denatured 60-kD or 52-kD Ro/SS-A proteins in Sjögren's syndrome. Arthritis Rheum 1994;37:88-92.
29. Sontheimer RD, Maddison PJ, Reichlin M, Jordan RE, Stastny P, Gilliam JK: Serologic and HLA association of a distinct clinical subset of lupus erythematosus: Subacute cutaneous lupus erythematosus. Ann Intern Med 1982;97:664-71.
30. Synkowski DR, Reichlin M, Provost TT: Serum autoantibodies in syslemic lupus erythematosus and correlation with cutaneous features. J Rheumatol 1982;9:380-9.
31. Wasicek CA, Reichlin M: Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La. J Clin Invest 1982;69:835-43.
32. Mond CB, Peterson MG, Rothfield NF: Correlation of anti-Ro antibody with photosensitivity rash in systemic lupus erythematosus. Arthritis Rheum 1989;32:202-4.
33. Thompson D, Juby A, Davis P: The clinical significance of autoantibody profiles in patients with systemic lupus erythematosus. Lupus 1993;2:15-9.
34. Reichlin M: Clinical and immunological significance of antibodies to Ro and La in systemic lupus erythematosus. Arthritis Rheum 1982;25:767-72.
35. Lee LA: Anti-Ro(SSA) and anti-La(SSB) antibodies in lupus erythematosus and in Sjögren's syndrome. Arch Dermatol 1988;124:61-2.
36. Provost TT, Talal N, Harley JB, Reichlin M, Alexander E: The relationship between anti-Ro(SSA) antibody positive Sjögren's syndrome and anti-Ro(SSA) antibody-positive lupus erythematosus. Arch Dermatol 1988;124:63-71.
37. Hamilton RG, Harley JB, Bias WB, et al: Two Ro (SSA) autoantibody responses in systemic lupus erythematosus. Correlation of HLA-DR/DQ specificities with quantitative expression of Ro(SSA) autoantibody. Arthritis Rheum 1988;31:496-505.
38. Vitali C, Bencivelli W, Isenberg DA, et al: Disease activity in systemic lupus erythematosus: Report of the Consensus Study Group of the European Workshop for Rheumatology Research. I. A descriptive analysis of 704 European lupus patients. Clin Exp Rheumatol 1992;10:527-39.
39. Harley JB, Sestak AL, Willis LG, Fu SM, Hansen JA, Reichlin M: A model for disease heterogeneity in systemic lupus erythematosus: Relationship between histocompatibility antigens, autoantibodies, lymphopenia or renal disease. Arthritis Rheum 1989;32:826-36.
40. Nossent JC, Henzen-Logman SC, Vroom TM, Huysen V, Berden JH, Swaak AJ: Relation between serological data at the time of biopsy and renal histology in lupus nephritis. Rheumatol Int 1991;11:77-82.
41. McCarty GA, Harley JB, Reichlin MB: A distinctive autoantibody profile in black female patients with lupus nephritis. Arthritis Rheum 1995;36:1560-5.
42. Buyon JP, Winchester RJ, Slade SG, et al: Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. Arthritis Rheum 1993;36:1263-73.
43. Julkunen H, Kurki P, Kaaja R, et al: Isolated congenital heart block. Long-term outcome of mothers and characterization of the immune response to SS-A/Ro and to SS-B/La. Arthritis Rheum 1993;36:1588-98.
44. Alexander E, Buyon JP, Provost TT, Guarnieri T: Anti-Ro/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome: An experimental model. Arthritis Rheum 1992;35:176-89.
45. Garcia S, Nascimento JHM, Bonfa E, et al: Cellular mechanisms of the conduction abnormalities induced in serum from anti-Ro/SSA-positive patients in rabbit hearts. J Clin Invest 1994;93:718-24.
46. Horsfall AC, Rose LM: Cross-reactive maternal autoantibodies and congenital heart block. J Autoimmun 1992;5:479-93.
47. Bell DA, Maddison PJ: Serologic subsets in systemic lupuserythematosus: An examination of autoantibodies in relationship to clinical features of disease and HLA antigens. Arthritis Rheum 1980;23:1268-73.
48. Smolen JS, Klippel JH, Penner E, et al: HLA-DR antigens in systemic lupus erythematosus: Association with specificity of autoantibody responses to nuclear antigens. Ann Rheum Dis 1987:46:457-62.
49. Arnett PC, Hamilton RG, Reveille JD, Bias WB, Harley JB, Reichlin M: Genetic studies of Ro (SS-A) and La (SS-B) autoantibodies in families with systemic lupus erythematosus and primary Sjögren's syndrome. Arthritis Rheum 1989;32:413-9.
50. Fujisaku A, Frank MB, Neas B, Reichlin M, Harley JB: HLA-DQ gene complementation and other histocompatibility relationships in man with the anti-Ro/SSA autoantibody response of systemic lupus erythematosus. J Clin Invest 1990;86:606-11.
51. Frank MB, McArthur R, Harley JB, Fujisaku A: Anti-Ro (SSA) autoantibodies are associated with T cell receptor ß genes in systemic lupus erythematosus. J Clin Invest 1990;85:33-9.
52. Barakat S, Meyer O, Torterotat F, et al. IgG antibodies from patients with primary Sjögren's syndrome and systemic lupus erythematosus recognize different epitopes in 60kD SSA/Ro protein. Clin Exp Immunol 1992;88:1-8.
53. Ricchiuti V, Briand JP, Meyer O, Isenberg DA, Pruijn G, Muller S: Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune disease. Clin Exp Immunol 1994;95:397-407.
54. Frank MB, Itoh K, McCubbin V: Epitope mapping of the 52-kD Ro/SSA autoantigen. Clin Exp Immunol 1994;95:390-6.
55. Blange I, Ringertz NR, Petterson I: Identification of antigenic regions of the human 52 kD Ro/SS-A protein recognized by patient sera. J Autoimmun 1994;7:263-74.
56. McCauliffe DP, Yin H, Wang LX, Lucas L: Autoimmune sera react with multiple epitopes on recombinant 52 and 60 kDa Ro (SSA) proteins. J Rheumatol 1994;21:1073-80.
57. Peek R, Pruijn GJ,van Venrooij WJ: Epitope specificity determines the ability of anti-Ro52 autoantibodies to precipitate Ro ribonucleoprotein particles. J Immunol 1994;153:4321-9.