Effects of thermochemotherapy [1-hexylcarbamoyl-5-fluorouracil (HCFU) combined with hyperthermia]: A basic study on the most effective timing and sequence in vivo

Anticancer Research

Volumn 16, Issue 5 A, 1996, Pages 2729-2733

  Sakurai, Kazuhiro ^a   Yoshiga, Koji ^a   Tsumura, Masanori ^a   Takada, Kazuaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

1 Hexylcarbamoyl 5 fluorouracil; Ehrlich ascites tumor; Hyperthermia; Thermochemotherapy

Indexed keywords

CARMOFUR; FLUOROURACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG TISSUE LEVEL; EHRLICH ASCITES TUMOR; HEATING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERTHERMIC THERAPY; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TIME; TREATMENT PLANNING; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; FLUOROURACIL; HYPERTHERMIA, INDUCED; MALE; MICE; TISSUE DISTRIBUTION;

EID: 0029908176     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Tsumura M, Yoshiga K and Takada K: Enhancement of antitumor effects of 1-hexylcarbamoyl-5-fluorouracil combined with hyperthermia on Ehrlich ascites tumor in vivo and Nakahara-Fukuoka sarcoma cell in vitro. Cancer Res 48: 3977-3980, 1998.
2. Mori K, Namekawa H, Misono H, Yokoyama Y and Kobari T: Methods for determination of HCFU and its metabolites in human body fluids by HPLC and ECD-GLC. Chemotherapy 29: 314-321, 1981.
3. Magin RL, Sikic BI and Cysyk RL: Enhancement of bleomycin activity against Lewis lung tumors in mice by local hyperthermia. Cancer Res 39: 3792-3795, 1979.
4. Lin P, Hefter K and Jones M: Hyperthermia and bleomycin schedules on V79 Chinese hamster cell cytotoxicity in vitro. Cancer Res 43: 4557-4561, 1983.
5. Dahl O and Mella O: Effect of timing and sequence of hyperthermia and cyclophosphamide on a neurogenic rat tumor (BT4A) in vivo. Cancer 52: 983-987, 1983.
6. Urano M, Kim MS, Kahn J, Kenton LA and Li ML: Effect of thermochemotherapy (combined cyclophosphamide and hyperthermia) given at various temperatures with or without glucose administration on a murinc fibrosarcoma. Cancer Res 45: 4162-4166, 1985.
7. Barlogic B, Corry PM and Drewinko B: In vitro thermochemotherapy of human colon cancer cells with cis-dichlorodiammineplatinum (II) and mitomycin C. Cancer Res 40: 1165-1168, 1980.
8. Teicher BA, Kowal CD, Kennedy KA and Sartorelli AC: Enhancement by hyperthermia of the in vitro cytotoxicity of mitomycin C toward hypoxic tumor cells. Cancer Res 41: 1096-1099, 1981.
9. Mella O and Dahl O: Timing of combined hyperthermia and 1,3-bis(2-chloroethyl)-1-nitrosourea or cis-diamminedichloroplatnim in BDIX rats with BT4A tumours. Anticancer Res 5: 259-264, 1985.
10. Murthy MS, Rao LN, Khandkar JD and Scanlon EF: Enhanced therapeutic efficiency of cisplatin by combination with diethyldithiocarbamatc and hyperthermia in a mouse model. Cancer Res 47: 774-779, 1987.
11. Kimura E and Howell SB: Analysis of the cytotoxic interaction between cisplatin and hyperthermia in a human ovarian carcinoma cell line. Cancer Chemother Pharmacol 32: 419-424, 1993.
12. Ohno S, Siddik ZH, Kido Y, Zwelling LA and Bull JMC: Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin induced eytotoxicity in L1210 cells. Cancer Chemother Pharmacol 34: 302-306, 1994.
13. Bates DA and Mackillop WJ: Hyperthermia, adriamycin transport and cytotoxicity in drug-sensitive and -resistant Chinese hamster ovary cells. Cancer Res 46: 5477-5481, 1986.
14. Hahn GM: Hyperthermia and cancer: Plenum Publishing Corp. New York: 74-82, 1982.
15. Bull JMC: An update on the anticancer effects of a combination of chemotherapy and hyperthermia. Cancer Res 44(Suppl): 4853-4856, 1984.
16. Ozaki S, Ike Y, Mizuno H, Ishikawa K and Mori H: 5-Fluorouracil derivatives. Bull Chem Soc Jpn 50: 2406-2412, 1977.
17. Kobari T, Iguro Y, Ujiie A and Namekawa H: Metabolism of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a new antitumor agent. in rats, rabbits and dogs. Xenobiotica 11: 57-62, 1981.
18. Hoshi A, Iigo M, Nakamura A, Yoshida M and Kurctani K: Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors. Jpn J Cancer Res (GANN) 67: 725-731, 1 976.
19. Iigo M, Hoshi A. Nakamura A and Kuretani K: Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumours. Cancer Chemother Pharmacol 1: 203-208, 1978.
20. Tokuzen R, Iigo M, Hoshi A and Kuretani K: Effect of 1-hexylcarbamoyl-5-fluorouracil on spontaneous mammary adenocarcinoma of mice. Jpn J Cancer Res (GANN) 71: 724-728, 1980.
21. Hahn GM, Braun J and Har-Kedar I: Thermochemotherapy: Synergism between hyperthermia (42-43 °C) and adriamycin (or bleomycin) in mammalian cell inactivation. Proc Natl Acad Sci USA 72: 937-940, 1975.
22. Hahn GM and Strande DP: Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cells. J Natl Cancer Inst 57: 1063-1067, 1976.
23. Nagaoka S, Kawasaki S, Sasaki Y and Nakanishi T: Intercellular uptake, retention and cytotoxic effect of adriamycin combined with hyperthermia in vitro. Jpn J Cancer Res (GANN) 78: 205-211, 1986.
24. Toffoli G, Bevilacqua C, Franceshi A and Boiocchi A: Effect of hyperthermia on intracellular drug accumulation and chemosensitivity in drug-sensitive and drug-resistant P388 leukemia cell lines. Int J Hyperthermia 5: 163- 172, 1989.
25. Braun J and Hahn GM: Enhanced cell killing by bleomycin and 43 °C hyperthermia and the inhibition of recovery from potentially lethal damage. Cancer Res 35: 2921-2927, 1975.
26. Kubota Y, Nishimura R, Takai S and Umeda M: Effect of hyperthermia on DNA single-strand breaks induced by bleomycin in Hela cells. Jpn J Cancer Res (GANN) 70: 681 -685, 1979.
27. Eddy HA: Alterations in tumor microvasclature during hyperthermia. Radiology 137: 515-521, 1980.
28. Kang MS, Song CW and Levitt SH: Role of vascular function in response of tumors in vivo to hyperthermia. Cancer Res 40: 1130-1135, 1980.
29. Song CW: Effect of local hyperthermia on blood flow and microenvironment: a review. Cancer Res 44(Suppl): 4721-4730. 1984.
30. Ikenaka K, Shirasaka T, Kitano and Pujii S: Effect of uracil on metabolism of 5-fluorouracil in vitro. Jpn J Cancer Res (GANN) 70: 353-359, 1979.