GAD65 autoantibodies in women with gestational or insulin dependent diabetes mellitus diagnosed during pregnancy

Diabetologia

Volumn 39, Issue 11, 1996, Pages 1329-1333

  Petersen, J S ^a,e   Dyrberg, T ^b   Damm, P ^c   Kuhl C ^b   Molsted Pedersen L ^c   Buschard, K ^d  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c Kommunehospitalet ^*  (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e ZYMOGENETICS INC   (United States)

Author keywords

GAD65; Gestational diabetes; HLA; IAA; ICA; Pregnancy

Indexed keywords

AUTOANTIBODY;

ADULT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AUTOANTIBODIES; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; DIABETES, GESTATIONAL; FEMALE; FORECASTING; GLUTAMATE DECARBOXYLASE; HUMANS; ISLETS OF LANGERHANS; MIDDLE AGED; PRECIPITIN TESTS; PREGNANCY;

EID: 0029908010     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050578     Document Type: Article

References (23)

1. 1.The Third International Workshop Conference on Gestational Diabetes Mellitus (1991) Summary and recommendations. Diabetes 40: 197-201
2. Gabbe S (1986) Gestational diabetes mellitus. N Eng J Med 315: 1025-1026
3. O'Sullivan JB (1989) The Boston gestational diabetes studies: review and perspectives. In: Sutherland HW, Stowers JM, Pearson DWM (eds) Carbohydrate metabolism in pregnancy and the newborn. Springer-Verlag, Berlin pp 287-294
4. Damm P. Kühl C, Buschard K et al. (1994) Prevalence and predictive value of islet cell antibodies and insulin autoantibodies in women with gestational diabetes. Diabet Med 11: 558-563
5. Damm P, Kühl C, Bertelsen A, Mølsted-Pedersen L (1992) Predictive factors for development of diabetes in women with previous geslational diabetes. Am J Obstel Gynecol 167: 607-616
6. Buschard K, Buch I, Mølsted-Pedersen L, Hougaard P, Kühl C (1987) Increased incidence of true type 1 diabetes acquired during pregnancy. BMJ 294: 275-279
7. Buschard K, Hougaard P, Mølsted-Pedersen L, Kühl C (1990) Type 1 (insulin-dependent) diabetes mellitus diagnosed during pregnancy: a clinical and prognostic study. Diabetologia 33: 31-35
8. Bækkeskov S, Aanstoot H-J, Christgau S et al. (1990) Identification of the 64 K autoantigen in insulin dependent diabetes as the GABA-synthesising enzyme glutamic acid decarboxylase. Nature 347: 151-156
9. Hagopian WA, Karlsen AE, Gottsater A et al. (1993) Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64 K autoantibody positivity at onset predicts diabetes type. J Clin Invest 91: 368-374
10. Thivolet CH, Tappaz M, Durand A et al. (1992) Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of type 1 (insulin-dependent) diabetes mellitus in high risk individuals. Diabetologia 35: 570-576
11. De Aizpurua HJ, Wilson YM, Harrison LC (1992) Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes. Proc Natl Acad Sci USA 89: 9841-9845
12. Bingley PJ, Christie MR, Bonifacio E et al. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43: 1304-1310
13. Petersen JS, Dyrberg T, Karlsen AE, Mølvig J, Nerup J, Mandrup-Poulsen T and the Canadian-European Randomized Control Trial Group (1994) Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent onset insulin-dependent diabetes mellitus following cyclosporin-treatment. Diabetes 43: 1291-1296
14. Buschard K, Mølsted-Pedersen L, Palmer J, Kühl C, Lund l E, Bottazzo GF (1989) Investigation in children who were in utero at onset of insulin-dependent diabetes in their mothers. Lancet (8642): 811-814
15. Møller-Jensen B, Buschard K, Bush I et al. (1987) HLA association in insulin-dependent diabetes mellitus diagnosed during pregnancy. Acta Endocrinol 116: 387-389
16. Kühl C (1975) Glucose metabolism during and after pregnancy in normal and gestational diabetic women. I. Influence of normal pregnancy on serum glucose and insulin concentration during basal fasting conditions and after a challenge with glucose. Acta Endocrinol 79: 709-719
17. 65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43: 459-467
18. Karlsen AE, Hagopian WA, Petersen JS et al. (1992) Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-Mr autoantibodies. Diabetes 41: 1355-1359
19. Catalano PM, Tyzbir ED, Sims EAH (1990) Incidence and significance of islet cell antibodies in women with previous gestational diabetes. Diabetes Care 13: 478-482
20. Freinkel N, Metzger BE, Phelps RL, Dooley S, Ogata ES, Radvany RM (1985) Gestational diabetes mellitus: heterogeneity of maternal age, weight, insulin secretion, HLA antigens and islet cell antibodies and the impact of maternal metabolism on pancreatic B-cell and somatic development in the offspring. Diabetes 34[Suppl 2]:1-7
21. Fallucca F, Di Mario U, Gargiulo P et al. (1985) Humoral immunity in diabetic pregnancy: interrelationship with maternal/neonatal complications and maternal metabolic control. Diabete Metab 11: 387-395
22. Tuomilehto J, Zimmet P, MacKay IR et al. (1994) Antibodies to glutamic acid decarboxylase as predictors of insulindependent diabetes mellitus before clinical onset of disease. Lancet 343: 1383-1385
23. Zanone MM, Petersen JS, Peakman M et al. (1994) High prevalence of autoantibodies to glutamic acid decarboxylase in long-standing insulin-dependent diabetes is not a marker of symptomatic autonomic neuropathy. Diabetes 43: 1146-1151