Effect of amplification of the Cap b locus on complement-mediated bacteriolysis and opsonization of type b Haemophilus influenzae

Infection and Immunity

Volumn 64, Issue 11, 1996, Pages 4769-4775

  Noel, Gary J ^a   Brittingham, Andrew ^b   Granato, Anthony A ^a   Mosser, David M ^b  

^a Department of Obstetrics Gynecology   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; MONOCLONAL ANTIBODY;

ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BACTERIOLYSIS; COMPLEMENT DEPOSITION; COMPLEMENT FIXATION; CONTROLLED STUDY; GENE LOCUS; HAEMOPHILUS INFLUENZAE TYPE B; HOST RESISTANCE; MACROPHAGE FUNCTION; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL;

EID: 0029907917     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.11.4769-4775.1996     Document Type: Article

References (27)

1. Anderson, P., R. B. Johnston, and D. H. Smith. 1972. Human serum activities against Haemophilus influenzae type b. J. Clin. Invest. 51:31-38.
2. Buckmire, F. L. A. 1982. Characterization of the capsular antigen isolated from Haemophilus influenzae type b and two spontaneous nonencapsulated mutants, p. 171-183. In S. H. Sell and P. F. Wright (ed.), Haemophilus influenzae: epidemiology, immunology and prevention of disease. Elsevier Science, New York.
3. Corn, P. G., J. Anders, A. K. Takala, H. Kayhty, and S. K. Hoiseth. 1993. Genes involved in Haemophilus influenzae type b capsule expression are frequently amplified. J. Infect. Dis. 167:356-364.
4. Crosson, F. J., J. A. Winklestein, and E. R. Moxon. 1976. Participation of complement in the nonimmune host defense against experimental Haemophilus influenzae type b septicemia and meningitis. Infect. Immun. 14: 882-887.
5. Gnehm, H. E., S. I. Pelton, S. Gulati, and P. A. Rice. 1985. Characterization of antigens from nontypeable Haemophilus influenzae recognized by human bactericidal antibodies. J. Clin. Invest. 75:1645-1658.
6. Hoiseth, S. K., E. R. Moxon, and R. P. Silver. 1986. Genes involved in Haemophilus influenzae type b capsule expression are part of an 18 kilobase tandem duplication. Proc. Natl. Acad. Sci. USA 83:1106-1110.
7. Hondalus, M. K., M. S. Diamond, L. A. Rosenthal, T. A. Springer, and D. M. Mosser. 1993. The intracellular bacterium Rhodococcus equi requires Mac-1 to adhere to mammalian cells. Infect. Immun. 61:2919-2929.
8. Kroll, J. S., B. M. Loynds, and E. R. Moxon. 1991. The Haemophilus influenzae capsulation gene cluster: a compound transposon. Mol. Microbiol. 5:1549-1560.
9. Kroll, J. S., and E. R. Moxon. 1988. Capsulation and gene copy number at the cap locus of Haemophilus influenzae type b. J. Bacteriol. 170:859-864.
10. Kroll, J. S., E. R. Moxon, and B. M. Loynds. 1993. An ancestral mutation enhancing the fitness and increasing the virulence of Haemophilus influenzae type b. J. Infect. Dis. 168:172-176.
11. Kuratana, M., and P. Andersen. 1991. Host metabolites that phenotypically increase the resistance of Haemophilus influenzae type b to clearance mechanisms. J. Infect. Dis. 163:1073-1079.
12. Kuratana, M., E. J. Hansen, and P. Anderson. 1990. Multiple mechanisms in scrum factor-induced resistance of Haemophilus influenzae type b to antibody. Infect. Immun. 58:914-919.
13. Mosser, D. M., J. F. Wedgewood, and P. J. Edelson. 1985. Leishmania amastigotes: resistance to complement-mediated lysis is not due to a failure to fix C3. J. Immunol. 134:4128-4131.
14. Moxon, E. R., and K. A. Vaughn. 1981. The type b capsular polysaccharide as a virulence determinant in infant rats after intranasal inoculation. J. Infect. Dis. 143:517-524.
15. Noel, G. J., S. J. Barenkamp, J. W. St. Geme III, W. M. Haining, and D. M. Mosser. 1994. High-molecular-weight surface-exposed proteins of Hae- mophilus influenzae mediate binding to macrophages. J. Infect. Dis. 169:425-429.
16. Noel, G. J., S. K. Hoiseth, and P. J. Edelson. 1992. Type b capsule inhibits ingestion of Haemophilus influenzae by murine macrophages: studies with isogenic encapsulated and unencapsulated strains. J. Infect. Dis. 166:178-182.
17. Noel, G. J., S. Kate, and P. J. Edelson. 1988. Complement-mediated early clearance of Haemophilus influenzae type b from blood is independent of serum lytic activity. J. Infect. Dis. 157:85-90.
18. Noel, G. J., D. M. Mosser, and P. J. Edelson. 1990. Role of complement in mouse macrophage binding of Haemophilus influenzae type b. J. Clin. Invest. 85:208-218.
19. Pittman, M. 1931. Variation and type specificity in the bacterial species Haemophilus influenzae. J. Exp. Med. 53:471-492.
20. Porto, M. H. O., G. J. Noel, P. J. Edelson, and The Brazilian Purpuric Fever Study Group. 1989. Resistance to serum bactericidal activity distinguishes Brazilian purpuric fever (BPF) case strains of Haemophilus influenzae biogroup aegyptius (H. aegyptius) from non-BPF strains. J. Clin. Microbiol. 27: 792-794.
21. Quinn, P. H., F. J. Crosson, J. A. Winklestein, and E. R. Moxon. 1977. Activation of the alternative complement pathway by Haemophilus influenzae type b. Infect. Immun. 16:400-402.
22. Smith, A. L., D. H. Smith, D. R. Averhill, Jr., J. Marino, and E. R. Moxon. 1973. Production of Haemophilus influenzae type b meningitis in infant rats by intraperitoneal inoculation. Infect. Immun. 8:278-290.
23. Tarr, P. I., S. W. Hosea, E. J. Brown, R. Schneerson, A. Sutton, and M. M. Frank. 1982. The requirement of specific anticapsular IgG for killing of Haemophilus influenzae by the alternative pathway of complement activation. J. Immunol. 128:1772-1775.
24. Turk, D. C., and J. R. May. 1967. Haemophilus influenzae: its clinical importance. English University Press, London.
25. Weiser, J. N. 1993. Relationship between colony morphology and the life cycle of Haemophilus influenzae: the contribution of lipopolysaccharide phase variation to pathogenesis. J. Infect. Dis. 168:672-680.
26. Weller, P. F., A. L. Smith, P. Andersen, and D. H. Smith. 1977. The role of encapsulation and host age in the clearance of Haemophilus influenzae bacteremia. J. Infect. Dis. 135:34-41.
27. Wessels, M. R., P. Butko, M. Ma, H. B. Warren, A. L. Lage, and M. C. Carrol. 1995. Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc. Natl. Acad. Sci. USA 92:11490-11494.