Macromolecular prodrug of diflunisal. II. Investigations of in vitro release and of photochemical behaviour

European Journal of Pharmaceutical Sciences

Volumn 4, Issue 5, 1996, Pages 273-282

  Giammona, Gaetano ^a   Cavallaro, Gennara ^a   Fontana, Giacomo ^a   De Guidi, Guido ^b   Giuffrida, Salvatore ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Diflunisal; Macromolecular prodrug; Photochemical reactions; Polyaspartamide

Indexed keywords

DIFLUNISAL; KETOPROFEN; NAPROXEN; POLYMER; PRODRUG;

ARTICLE; DRUG DECOMPOSITION; DRUG RELEASE; ERYTHROCYTE; HEMOLYSIS; HUMAN; HYDROLYSIS; PHOTODEGRADATION; PRIORITY JOURNAL; STOMACH JUICE;

EID: 0029907534     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(96)00175-3     Document Type: Article

References (4)

1. Antoni, G., Neri, P., Pedersen, T.G. and Ottesen, M. (1974) Hydrodynamic properties of a new plasma expander: Poly(hydroxyethyl)aspartamide. Biopolymers 13, 1721-1729.
2. Antoni, G., Arezzini, C., Cocola, F., Gazzei, G. and Neri, P (1979) Pharmacological and toxicological evalutation of polyhydroxyethylaspartamide (PHEA) as a plasma substitute. II Farmaco Ed. Pr. 34 (4), 146-156.
3. Calvert, G. and Pitts, J. (1966) Photochemistry. Wiley, New York, pp. 783-786.
4. Castelli, F., Giammona, G., Raudino, A. and Puglisi, G. (1941) Macromolecular prodrugs interaction with mixed lipid membrane. A calorimetric study of naproxen linked to polyaspartamide interacting with phosphatidylcholine and phosphatidylcholine-phosphatic acid vesicles. Int. J. Pharm. 70, 43-52.