Inhibition by P1075 and pinacidil of a calcium-independent chloride conductance in conditionally-immortal renal glomerular mesangial cells

British Journal of Pharmacology

Volumn 119, Issue 4, 1996, Pages 772-778

  Barber, Robert D ^a,b   Henderson, Robert M ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Chloride conductance; H 2Kb tsA58; P1075; Pinacidil

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; CALCIUM ION; CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT; TETRAMETHYLAMMONIUM CHLORIDE;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; GLOMERULUS; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029907121     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15739.x     Document Type: Article

References (26)

1. ALTON, E.W.F.W. & WILLIAMS, A.J. (1992). Modification of gating of an airway epithelial chloride channel by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB). J. Membr. Biol., 128, 141 - 151.
2. b-tsA58 transgenic mouse. Biochim. Biophys. Acta, 1269, 267-274.
3. b-tsA58 transgenic mouse. Br. J. Pharmacol., 115, 12P.
4. 1-conductance pathway in Cl -transporting epithelia. Pflügers Arch., 405, S95 - S100.
5. 29) as revealed by 5-nitro-2-(3-phenylpropylamino) benzoic acid. Biochim. Biophys. Acta, 946, 135-142.
6. FABIATO, A. & FABIATO, F. (1979). Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J. Physiol. (Paris), 75, 463 - 505.
7. + channels in guinea pig ventricular myocytes. J. Membr. Biol., 136, 289-302.
8. GEKLE, M., OBERLEITHNER, H. &. SILBERNAGL, S. (1993). Ochratoxin A impairs 'postproximal' nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro. Pflügers Arch., 425, 401 - 408.
9. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflügers Arch., 391, 85 - 100.
10. HOGG, R.C., WANG, Q. & LARGE, W.A. (1994). Effects of Cl channel blockers on Ca-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein. Br. J. Pharmacol., 111, 1333 - 1341.
11. 1 channel inhibitor in vascular smooth muscle cells. J. Membr. Biol., 137, 59 - 70.
12. b-tsA58 transgenic mouse. Proc. Natl. Acad. Sci. U.S.A., 88, 5096-5100.
13. 2+-dependent chloride current in mouse pituitary cells. J. Physiol., 439, 423-437.
14. KREISBERG, J.I., VENKATACHALAM, M. & TROYER, D. (1985). Contractile properties of cultured glomerular mesangial cells. Am. J. Physiol., 249, F457 - F463.
15. KREISBERG, J.I. & KARNOVSKY, M.J. (1983). Glomerular cells in culture. Kidney Int., 23, 439 - 447.
16. KREMER, S.G., BREUER, W.V. & SKORECKI, K.L. (1989). Vasoconstrictor hormones depolarize renal glomerular mesangial cells by activating chloride channels. J. Cell. Physiol., 138, 97 - 105.
17. 2+, PKC, and G proteins. Am. J. Physiol., 262, F668-F678.
18. MENÉ, P., SIMONSON, M.S. & DUNN, M.J. (1989). Physiology of the mesangial cell. Physiol. Rev., 69, 1347-1424.
19. OKUDA, T., YAMASHITA, N. & KUROKAWA, K. (1986). Angiotensin II and vasopressin stimulate calcium-activated chloride conductance in rat mesangial cells. J. Clin. Invest., 78, 1443 - 1448.
20. OTTOLIA, M. & TORO, L. (1994). Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys. J., 67, 2272 - 2279.
21. RAE, J.L. & FARRUGIA, G. (1992). Whole-cell potassium current in rabbit corneal epithelium activated by fenamates. J. Membr. Biol., 129, 81 - 97.
22. + channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents. J. Gen. Physiol., 100, 573 - 591.
23. 1 conductance. Circ. Res., 77, 417 - 423.
24. VENKATACHALAM, M.A. & KREISBERG, J.I. (1985). Agonist-induced isotonic contraction of cultured mesangial cells after multiple passage. Am. J. Physiol., 249, C48 - C55.
25. VOLK, T., RABE, A. & KORBMACHER, C. (1995). Glibenclamide inhibits an outwardly rectifying chloride channel in M-1 mouse cortical collecting duct cells. Cell. Physiol. Biochem., 5, 222 - 231.
26. 1-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship. Pflügers Arch., 407, S128-S141.