Interleukin-2 receptor levels in sera of patients with rheumatoid arthritis treated with sulfasalazine, parenteral gold, or placebo

Journal of Rheumatology

Volumn 23, Issue 11, 1996, Pages 1856-1861

  Merkel, Peter A ^a   Dooley, Mary Anne ^b   Dawson, Deborah V ^c   Pisetsky, David S ^b   Polisson, Richard P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Division of Rheumatology

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Gold; Interleukin 2; Rheumatoid arthritis; Sulfasalazine

Indexed keywords

AUROTHIOMALATE; INTERLEUKIN 2 RECEPTOR; PLACEBO; SALAZOSULFAPYRIDINE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS;

ADULT; AGED; ARTHRITIS, RHEUMATOID; BLOOD SEDIMENTATION; FEMALE; GOLD SODIUM THIOMALATE; HUMANS; JOINTS; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; SULFASALAZINE; TREATMENT OUTCOME;

EID: 0029907108     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Decker JL, Malone DG, Haraoui B, et al: Rheumatoid arthritis: Evolving concepts of pathogenesis and treatment. Ann Intern Med 1984;101:810-24.
2. Strober S, Holoshitz J: Mechanisms of immune injury in rheumatoid arthritis: Evidence for the involvement of T cells and heat-shock proteins. Immunol Rev 1990;118:233-55.
3. Rubin LA, Kurman CC, Fritz ME, et al: Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol 1985;135:3172-7.
4. Rubin LA, Nelson DL: The soluble interleukin-2 receptor: Biology, function, and clinical application. Ann Intern Med 1990;113:619-27.
5. Campen DH, Horwitz DA, Quismorio FP Jr, Ehresmann GR, Martin WJ: Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by immune system activation. Arthritis Rheum 1988;31:1358-64.
6. Keystone EC, Snow KM, Bombardier C, Change C, Nelson DL, Rubin LA: Elevated soluble interleukin-2 receptor levels in the sera and synovial fluids of patients with rheumatoid arthritis. Arthritis Rheum 1988;31:844-9.
7. Semenzato G, Bambara LM, Biasi D, et al: Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis. J Clin Immunol 1988;8:447-52.
8. Symons JA, Wood NC, Di Giovine FS, Duff GW: Soluble IL-2 receptor in rheumatoid arthritis: Correlation with disease activity, IL-1 and IL-2 inhibition. J Immunol 1988;141:2612-8.
9. Wood NC, Symons JA, Duff GW: Serum interleukin-2-receptor in rheumatoid arthritis: A prognostic indicator of disease activity? J Autoimmun 1988;1:353-61.
10. Manossakis MN, Papadopoulos GK, Drosos AA, Moutsopoulos H: Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases. Clin Immunol Immunopathol 1989;50:321-32.
11. Carpenter AB, Eisenbeis CH Jr, Carrabis S, Brown MC, Ip SH: Soluble interleukin-2 receptor: Elevated levels in serum and synovial fluid of patients with rheumatoid arthritis. J Clin Lab Anal 1990;4:130-4.
12. Rubin LA, Snow KM, Kurman CC, Nelson DL, Keystone EC: Serial levels of soluble interleukin 2 receptor in the peripheral blood of patients with rheumatoid arthritis: Correlations with disease activity. J Rheumatol 1990;17:597-602.
13. Vaisberg M, Scheinberg MA: Simultaneous evaluation of membrane bound and soluble interleukin 2 receptor expression in the blood and synovial fluid of patients with rheumatoid arthritis. Clin Exp Rheumatol 1990,8:519-82.
14. Zielinski CC, Resau B, Muller CH: Soluble interleukin-2-receptor and soluble CD8 antigen in active rheumatoid arthritis. Clin Immunol Immunopathol 1990;57:74-82.
15. Beckham JC, Caldwell DS, Peterson BL, et al: Disease severity in rheumatoid arthritis: Relationships of plasma tumor necrosis factor-α, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures. J Clin Immunol 1992;12:353-61.
16. Holt I, Cooper RG, Denton J, Meager A, Hopkins SJ: Cytokine inter-relationships and their association with disease activity in arthritis. Br J Rheumatol 1992;31:725-33.
17. Wolf RE, Brelsford WO, Hall VC, Adams SB: Cytokines and soluble interleukin 2 receptors in rheumatoid arthritis. J Rheumatol 1992;19:524-8.
18. Barrera P, Boerbooms AM, Janssen EM, et al: Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor α, and interleukin-6 levels in rheumatoid arthritis. Arthritis Rheum 1993;36:1070-9.
19. Crilly A, Madhok R, Watson J, Capell HA: Serum concentrations of soluble interleukin 2 receptor in patients with rheumatoid arthritis: Effect of second line drugs. Ann Rheum Dis 1993;52:58-60.
20. Dooley MA, Cush JJ, Lipsky PE, Dawson DV, Pisetsky DS: The effects of nonsteroidal antiinflammatory drug therapy in early rheumatoid arthritis on serum levels of soluble interleukin 2 receptor, CD4, and CD8. J Rheumatol 1993;20:1857-62.
21. Harrington L, Affleck G, Urrows S, et al: Temporal covariation of soluble interleukin-2 receptor levels, daily stress, and disease activity in rheumatoid arthritis. Arthritis Rheum 1993;36:199-203.
22. Kirkham BW, Davison SC, Corkill MM, Barbatis C, Panayi GS: Serial soluble interleukin 2 receptor levels in rheumatoid arthritis: Differences in response to glucocorticoid treatment and chrysotherapy. J Rheumatol 1993;20:935-9.
23. Kullich W: Correlation of interleukin-2 receptor and neopterin secretion in rheumatoid arthritis. Clin Rheumatol 1993,12:387-91.
24. Matsumoto T, Iwasaki K: Clinical and laboratory parameters which affect soluble interleukin-2 receptor levels in the serum and synovial fluids of patient with rheumatoid arthritis. Ann Rheum Dis 1993;52:876-80.
25. Boiardi L, Macchioni P, Salvarani C, et al: Serum soluble interleukin-2 receptor levels in rheumatoid arthritis: Correlation with clinical and immunological parameters and with the response to auranofin treatment. Clin Exp Rheumatol 1994;12:357-62.
26. Crilly A, McInnes IB, Capell HA, Madhok R: The effect of azathioprine on serum levels of interleukin 6 and soluble interleukin 2 receptor. Scand J Rheumatol 1994;23:87-91.
27. Polisson RP, Dooley MA, Dawson DV, Pisetsky DS: Interleukin-2 receptor levels in the sera of rheumatoid arthritis patients treated with methotrexate. Arthritis Rheum 1994;37:50-6.
28. van den Brink HR, van Wijk MJG, Geertzen ROM, Bijlsma JWJ: Influence of corticosteroid pulse therapy on the serum levels of soluble interleukin 2 receptor, interleukin 6 and interleukin 8 in patients with rheumatoid arthritis. J Rheumatol 1994;21:430-4.
29. Ward MM, Pyun E, Pisetsky DS: Serial measurement of serum interleukin-2 receptor levels in patients with rheumatoid arthritis: Limited evidence for a role of T cell activation in clinical exacerbations. Clin Immunol Immunopathol 1994;73:296-304.
30. Williams JH, Ward JR, Dahl SL, et al: A controlled trial comparing sulfasalazine, gold sodium thiomalate, and placebo in rheumatoid arthritis. Arthritis Rheum 1988;31:702-13.
31. Ropes MW, Bennett GA, Cobb S, Jacox R, Jessar RA: 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 1958;9:175-6.
32. Rubin LA, Kurman CC, Biddison WE, Goldman ND, Nelson DL: A monoclonal antibody, 7G7/B6, that binds to an epitope on the human IL-2R distinct from that recognized by IL2 or anti-Tac. Hybridoma 1985;4:91-102.
33. Nelson DL, Rubin LA, Kurman CC, Fritz ME, Boutin B: An analysis of the cellular requirement for the production of soluble interleukin-2 receptors in vitro. J Clin Immunol 1986;6:114-20.
34. Degiannis D, Seibold JR, Czarecki M, Raskova J, Taska K: Soluble and cellular markers of immune activation in patients with systemic sclerosis. Clin Immunol Immunopathol 1990;56:259-70.
35. Kahaleh MB: Soluble immunologic products in scleroderma sera. Clin Immunol Immunopathol 1991;58:139-44.
36. Schmitt WH, Heesen C, Csernok E, Rautmann A, Gross WL: Elevated serum levels of soluble interleukin-2 receptor in patients with Wegener's granulomatosis. Arthritis Rheum 1992;35:1088-95.
37. Felson DT, Anderson JJ, Boers M, et al: American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995;6:727-35.
38. Waldmann TA, Goldman CK, Robb RJ, et al: Expression of interleukin-2 receptors on activated B-cells. J Exp Med 1984;160:1450-66.