Biological determinants of difficult to treat patients with schizophrenia

British Journal of Psychiatry

Volumn 169, Issue DEC. SUPPL. 31, 1996, Pages 5-9

  Sharma, Tonmoy ^a   Kerwin, Robert ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGY; HUMAN; REVIEW; SCHIZOPHRENIA; THERAPY RESISTANCE; BIOAVAILABILITY; BRAIN; CLASSIFICATION; COGNITIVE DEFECT; DIAGNOSTIC IMAGING; DRUG RESISTANCE; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOLOGY; TREATMENT OUTCOME; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; BRAIN TISSUE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE DURATION; MENTAL PATIENT; NEUROCHEMISTRY; PSYCHIATRIC TREATMENT; TREATMENT RESPONSE;

NEUROLEPTIC AGENT; DOPAMINE 2 RECEPTOR; PROLACTIN;

ANTIPSYCHOTIC AGENTS; BIOLOGICAL AVAILABILITY; BRAIN; DELIRIUM, DEMENTIA, AMNESTIC, COGNITIVE DISORDERS; DIAGNOSTIC IMAGING; DRUG RESISTANCE; HUMANS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TREATMENT OUTCOME;

EID: 0029906998     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/s0007125000298553     Document Type: Review

References (46)

1. BALDESSARINI, R. J., COHEN, B. D. & TERCHER, M. H. (1988) Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses. Archives of General Psychiatry, 45, 79 91.
2. BILDER, R. M., WU, H., CHAKOS, M. H., et al (1994) Cerebral morphometry and clozapine treatment in schizophrenia. Journal of Clinical Psychiatry, 55 (Suppl. B), 53 56.
3. BOGERTS, B., ASHTARI, M., DEGREEF, G., et al (1990) Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Research, 35, 1 13.
4. _, FALKAI, P. & GREVE., B. (1991) Evidence of reduced temporolimbic structure volumes in schizophrenia [letter; comment]. Archives of General Psychiatry, 48, 956 958.
5. , LIEBERMAN, J. A., ASHTARI, M., et al (1993) Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biological Psychiatry, 33, 236 246.
6. BORONOW, J., PICKAR, D., NINAN, P. T., et al (1985) Atrophy limited to the third ventricle in chronic schizophrenic patients. Report of a controlled series. Archives of General Psychiatry, 42, 266 271.
7. BRFIER, A., BUCHANAN, R. W., ELKASHEF, A., et al (1992) Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Archives of General Psychiatry, 49, 921 926.
8. BROWN, W. A. & HERZ, L. R. (1989) Response to neuroleptic drugs as a device for classifying schizophrenia. Schizophrenia Bulletin, 15, 123 129.
9. CAZZULLO, C. L. (1963) Biological and clinical studies on schizophrenia related to pharmacological treatment. Recent Advances in Biological Psychiatry, 5, 114 143.
10. COPPENS, H., SLOOF, C. J., PAANS, M. C., et al (1991) High central D2 dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy resistant patients. Biological Psychiatry, 29, 629-634.
11. CURTIS, V. A. & KERWIN, R. W. (1995) Evidence for a role for serotonin in schizophrenia implications for pharmacological management. Journal of Serotonin Research, 2, 1-7.
12. DELISI, L. E., HOFF, A. L., KUSHNER, M., et al (1992) Left ventricular enlargement associated with diagnostic outcome of schizophreniform disorder. Biological Psychiatry, 32, 199-201.
13. FRIEDMAN, L., KNUTSON, L., SHURELL, M., et al (1991) Prefrontal sulcal prominence is inversely related to response to clozapine in schizophrenia. Biological Psychiatry, 29, 865-877.
14. _, LYS, C. & SCHULZ, S. C. (1992) The relationship of structural brain imaging parameters to antipsychotic treatment response: a review. Journal of Psychiatry and Neuroscience, 17, 42-54.
15. HONER, W., SMITH, G. N., LAPOINTE, J. S., et al (1995) Regional cortical anatomy and clozapine response in refractory schizophrenia. Neuropsychopharmacology, 13, 85 87.
16. GRODZICKI, J., PARDO, M., SCHUED, C., et al (1990) Differences in 3H spiperone binding to peripheral blood lymphocytes from neuroleptic responsive and non-responsive patients. Biological Psychiatry, 27, 1327 1330.
17. JESTE, D. V., KLEINMAN, J. E., POTKIN, S. G., et al (1982) Ex uno multi: subtyping the schizophrenic syndrome. Biological Psychiatry, 17, 199 222.
18. JEWART, R. D., LEWINE, R. R. J., MANNING, D. E., et al (1991) Brain MRI abnormalities associated with reduced antipsychotic response to clozapine. Pp. 44A. New Orleans, Louisiana: Society of Biological Psychiatry.
19. JOHNSTONE, E. C., CROW, T. J., FRITH, C. D., et al (1976) Cerebral ventricular sizc and cognitive impairment in chronic schizophrenia. Lancet, ii, 924-926.
20. KAIYA, H., UEMATSU, M., OFUJI, M., et al (1989) Computerised tomography in schizophrenia. Familial versus non-familial forms of illness. British Journal of Psychiatry, 155, 444-450.
21. KOLAKOWSKA, T., WILLIAMS, A. O., ARDERN, M., et al (1985) Schizophrenics with good and poor outcome. I. Early clinical features, response to neuroleptics and signs of organic dysfunction. British Journal of Psychiatry, 146, 229 234.
22. LIEBERMAN, J., BOGERTS, B, DEGREEF, G., et al (1992) Qualitative assessment of brain morphology in acute and chronic schizophrenia. American Journal of Psychiatry, 149, 784 794.
23. _, JODY, D., GEISLER, S., et al (1993a) Time course and biologic correlates of treatment response in first-episode schizophrenia. Archives of General Psychiatry, 50, 369-376.
24. _, _, ALVIR, J. M., et al (1993b) Brain morphology, dopamine, and eye-tracking abnormalities in first-episode schizophrenia. Prevalence and clinical correlates. Archives of General Psychiatry, 50, 357 368.
25. LUCHINS, D. J. & MELTZER, H. Y. (1983) A blind, controlled study of occipital cerebral asymmetry in schizophrenia. Psychiatry Research, 10, 87-95.
26. _, LEWINE, R. R. & MELTZER, H. Y. (1984) Lateral ventricular size, psychopathology, and medication response in the psychoses. Biological Psychiatry, 19, 29-44.
27. MACDONALD, H. L. & BEST, J. J. (1989) The Scottish First Episode Schizophrenia Study. VI. Computerised tomography brain scans in patients and controls. British Journal of Psychiatry, 154, 492 498.
28. NABER, D., ALBUS, M., BURKE, H., et al (1985) Neuroleptic withdrawal in chronic schizophrenia: CT and endocrine variables relating to psychopathology. Psychiatry Research, 16, 207 219.
29. NASRALLAH, H. A., KUPERMAN, S., HAMRA, B. J., et al (1983) Clinical differences between schizophrenic patients with and without large cerebral ventricles. Journal of Clinical Psychiatry, 44, 407-409.
30. NIMGAONKAR, V. L., WESSELY, S., TUNE, L. E., et al (1988) Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement. Psychological Medicine, 18, 583-592.
31. PANDURANGI, A. K., GOLDBERG, S. C., BRINK, D. D., et al (1989) Amphetamine challenge test, response to treatment, and lateral ventricle size in schizophrenia. Biological Psychiatry, 25, 207 214.
32. PILOWSKY, L. S., COSTA, D. C., ELL, P. J., et al (1993) Antipsychotic medication, D2 dopamine receptor blockade and clinical response to 123I-IBZM SPET (Single Photon Emission Tomography) study. Psychological Medicine, 23, 791-797.
33. SCHULZ, S. C., SINICROPE, P., KISHORE, P., et al (1983) Treatment response and ventricular brain enlargement in young schizophrenic patients. Psychopharmacology Bulletin, 19, 510-512.
34. SMITH, R. C., LARGEN, J., CALDERON, M., et al (1983) CT scans and neuropsychological tests as predictors of clinical response in schizophrenics. Psychopharmacology Bulletin, 19, 505-509.
35. , BAUMGARTNER, R., RAVICHANDRAN, G. K., et al (1985) Lateral ventricular enlargement and clinical response in schizophrenia. Psychiatry Research, 14, 241-253.
36. , , , et al (1987) Cortical atrophy and white matter density in the brains of schizophrenics and clinical response to neuroleptics. Acta Psychiatrica Scandinavica, 75, 11-19.
37. UEMATSU, M. & KAIYA, H. (1988) Cerebellar vermal size predicts drug response in schizophrenic patients: a magnetic resonance imaging (MRI) study. Progress in Neuropsychopharmacology and Biological Psychiatry, 12, 837-848.
38. _ & _ (1989) Midsagittal cortical pathomorphology of schizophrenia: a magnetic resonance imaging study. Psychiatry Research, 30, 11-20.
39. VAN KAMMEN, D. P. (1991) The biochemical basis of relapse and drug response in schizophrenia: a review and hypothesis. Psychological Medicine, 21, 881-895.
40. VITA, A., SACCHTTI, E., CALZERONI, A., et al (1988) Cortical atrophy in schizophrenia. Prevalence and associated features. Schizophrenia Research, 1, 329-337.
41. , DIECI, M., GIOBBIO, G. M., et al (1991) CT scan abnormalities and outcome of chronic schizophrenia. American Journal of Psychiatry, 148, 1577-1579.
42. WILMS, G., VAN ONGEVAL, C., BAERT, A. L., et al (1992) Ventricular enlargement, clinical correlates and treatment outcome in chronic schizophrenic patients. Acta Psychiatrica Scandinavica, 85, 306-312.
43. WEINBERGER, D. R., FULLER TORREY, E., NEOPHYTIDES, A. N., et at (1979) Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. Archives of General Psychiatry. 36, 935-939.
44. _, CANNON-SPOOR, E., POTKIN, S. G., et al (1980) Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. American Journal of Psychiatry 137, 1410-1413.
45. _, DELISI, L. E., PERMAN, G. P., et al (1982) Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Archives of General Psychiatry, 39, 778-783.
46. WOLKIN, A., BAROUCHE, F., WOLF, A. P., et al (1989) Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia. American Journal of Psychiatry, 146, 905-908.