Normal pituitary size in two patients with growth hormone gene deletion

Journal of Pediatric Endocrinology and Metabolism

Volumn 9, Issue 5, 1996, Pages 545-548

  Zucchini, Stefano ^a   Ambrosetto, Paolo ^b   Baroncini, Claudia ^c   Cacciari, Emanuele ^a,d  

^a 1st Pediatric Clinic   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d Clinica Pediatrica   (Italy)

Author keywords

Growth hormone gene; Magnetic resonance imaging; Pituitary; Somatotropin

Indexed keywords

GROWTH HORMONE;

ARTICLE; CASE REPORT; FEMALE; GENE DELETION; GROWTH RETARDATION; HUMAN; HYPOPHYSIS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN SIZE; SCHOOL CHILD;

CHILD; FEMALE; GENE DELETION; HUMAN GROWTH HORMONE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PITUITARY GLAND;

EID: 0029906946     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Kikuchi K, Fujisawa I, Momoi T, Yamanaka C, Kaji M, Nakano Y, Konishi J, Mikawa H, Sudo K. Hypothalamic-pituitary function in growth hormone-deficient patients with pituitary stalk transection. J Clin Endocrinol Metab 1988; 67: 817-823.
2. Cacciari E, Zucchini S, Carlá G, Pirazzoli P, Cicognani A, Mandini M, Busacca M, Trevisan C. Endocrine function and morphological findings in patients with disorders of the hypothalamo-pituitary area: a study with magnetic resonance. Arch Dis Child 1990; 65: 1199-1202
3. Maghnie M, Triulzi F, Larizza D, Preti P. Priora C, Scotti G, Severi F. Hypothalamic-pituitary dysfunction in growth hormone-deficient patients with pituitary abnormalities. J Clin Endocrinol Metab 1991; 73: 79-83.
4. Argyropoulou M, Prignon F, Brauner R, Brunelle F. Magnetic resonance imaging in the diagnosis of growth hormone deficiency. J Pediatr 1992; 120: 886-891.
5. Triulzi F, Scotti G, di Natale B, Pellini C, Lukezic M, Scognamiglio M, Chiumello G. Evidence of a congenital midline brain anomaly in pituitary dwarfs: a magnetic resonance imaging study in 101 patients. Pediatrics 1994; 93: 409-416.
6. Hayakawa K, Konishi Y, Matsuda T, Kuriyama M, Konishi K, Yamashita K, Okumura R, Hamanaka D. Development and aging of brain midline structures: assessment with MR imaging. Radiology 1989; 172: 171-177.
7. Martha PM Jr, Krieg RJ Jr. Batson JM, Rogol AD, Evans WS. Growth hormone secretion by individual somatotropes of the testicular feminized rat. Endocrinology 1989; 124: 1124-1130.
8. Baroncini C, Baldazzi L, Pirazzoli P, Marchetti G, Capelli M, Cacciari E, Bernardi F. Deletion breakpoints in a 32 bp perfect repeat located 45.1 kb apart in the human growth hormone gene cluster. Hum Mol Genet 1993; 2: 2151-2153.
9. Cacciari E, Pirazzoli, P, Gualandi S, Baroncini C, Baldazzi L, Trevisani B, Capelli M, Zucchini S, Balsamo A, Cicognani A. Molecular study of human growth hormone gene cluster in three families with isolated growth hormone deficiency and similar phenotype. Eur J Pediatr 1994; 153: 635-641.
10. Elster AD, Chen MYM, Williams DW III, Key LL Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology 1990; 174: 681-685.
11. Mayo KE, Hammer RE, Swanson LW, Brinster RL, Rosenfeld MG, Evans RM. Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. Mol Endocrinol 1988; 2: 606-612.
12. Perignon F, Brauner R, Argyropoulou M, Brunelle F. Precocious puberty of girls: pituitary height as an index of hypothalamo-pituitary activation. J Clin Endocrinol Metab 1992; 75: 1170-1172.
13. Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA. Mutation of the POU-specific domain of Pit-1 as a cause of hypopituitarism without pituitary hypoplasia. Science 1992; 257: 1118-1121.
14. Cohen LE, Wondisford FE, Salvatoni A, Maghnie M, Brucker-Davis F, Weintraub BD, Radovick S. A hot spot in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates. J Clin Endocrinol Metab 1995; 80: 679-684.