Bcl-2 expression in colorectal tumors: Evidence of different pathways in sporadic and ulcerative-colitis-associated carcinomas

American Journal of Pathology

Volumn 149, Issue 5, 1996, Pages 1719-1726

  Ilyas, Mohammad ^a,e   Tomlinson, Ian P M ^b   Hanby, Andrew M ^c   Yao, Takashi ^d   Bodmer, Walter F ^b   Talbot, Ian C ^a  

^a ST MARK S HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c ROYAL COLLEGE OF SURGEONS OF ENGLAND   (United Kingdom)

^d KYUSHU UNIVERSITY   (Japan)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR MARKER;

ARTICLE; COLORECTAL TUMOR; GENE ACTIVATION; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENE REPLICATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

CARCINOMA; COLITIS, ULCERATIVE; COLORECTAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0029905941     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Foulds L: The natural history of cancer. J Chronic Dis 1958, 8:2-37
2. Weinberg RA: Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res 1989, 49:3713-3721
3. Weinberg RA: The integration of molecular genetics into cancer management. Cancer 1992, 70:1653-1658
4. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767
5. Modrich P: Mechanisms and biological effects of mismatch repair, Annu Rev Genet 1991, 25:229-253
6. Fishel R, Kolodner RD: Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev 1995, 5:382-395
7. Aaltonen LA Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A: Clues to the pathogenesis of familial colorectal cancer. Science 1993, 260:812-816
8. Peltomaki P: Microsatellite instability and hereditary non-polyposis colon cancer, J Pathol 1995, 176: 329-330
9. Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 1993, 260:816-819
10. Kim H, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994, 145:148-156
11. Levin B: Inflammatory bowel disease and cancer. Cancer 1992, 70:1313-1316
12. Gyde S, Prior P, Allan R, Stevens A, Jewell D, Truelove S, Lofberg R, Brostrom O, Hellers G: Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres. Gut 1988, 29:206-217
13. Morson B, Dawson I, Day D, Jass J, Price A, Williams G: Morson and Dawson's Gastrointestinal Pathology, ed 3. Oxford, Blackwell Scientific Publications, 1990
14. Riddell R, Goldman H, Ransohoff D, Appelman H, Ahren C, Correa P, Hamilton S, Morson B, Sommers S, Yardley J: Dysplasia in inflammatory bowel disease: standardised classification with provisional clinical applications. Hum Pathol 1983, 14:931-968
15. Connell WR, Talbot IC, Harpaz N, Britto N, Wilkinson KH, Kamm MA, Lennard-Jones JE: Clinicopathological characteristics of colorectal carcinoma complicating ulcerative colitis. Gut 1994, 35:1419-1423
16. Bell SM, Kelly SA, Hoyle JA, Lewis FA, Taylor GR, Thompson H, Dixon MF, Quirke P: C-ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis. Br J Cancer 1991, 64:174-178
17. Greenwald BD, Harpaz N, Yin J, Huang Y, Tong Y, Brown VL, McDaniel T, Newkirk C, Resau JH, Meltzer SJ: Loss of heterozygosity affecting the p53, Rb, and mcclapc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer Res 1992, 52: 741-745
18. Redston M, Papadopoulos N, Caldas C, Kinzler K, Kern S: Common occurrence of APC and K-ras mutation in the spectrum of colitis-associated neoplasias. Gastroenterology 1995, 108:383-392
19. Tarmin L, Yin J, Harpaz N, Kozam M, Noordzij J, Antonio LB, Jiang HY, Chan O, Cymes K, Meltzer SJ: Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms. Cancer Res 1995, 55:2035-2038
20. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990, 348:334-336
21. Korsmeyer SJ: Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992, 80: 879-886
22. Tsujimoto Y, Cossman J, Jaffe E, Croce CM: Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985, 228:1440-1443
23. Weiss LM, Warnke RA, Sklar J, Cleary ML: Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas. N Engl J Med 1987, 317:1185-1189
24. Lu QL, Poulsom R, Wong L, Hanby AM: Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J Pathol 1993, 169:431-437
25. LeBrun DP, Warnke RA, Cleary ML: Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 1993, 142:743-753
26. Colombel M, Symmans F, Gil S, O'Toole KM, Chopin D, Benson M, Olsson CA, Korsmeyer S, Buttyan R: Detection of the apoptosis-suppressing oncoprotein Bcl-2 in hormone-refractory human prostate cancers. Am J Pathol 1993, 143:390-400
27. Pezzella F, Turley H, Kuzu I, Tungekar MF, Dunnill MS, Pierce CB, Harris A, Gatter KC, Mason DY: Bcl-2 protein in non-small-cell lung carcinoma. N Engl J Med 1993, 329:690-694
28. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ: BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991, 88:6961-6965
29. Bronner MP, Culin C, Reed JC, Furth EE: The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 1995, 146:20-26
30. Hague A, Moorghen M, Hicks D, Chapman M, Paraskeva C: BCL-2 expression in human colorectal adenomas and carcinomas. Oncogene 1994, 9:3367-3370
31. Ilyas M, Jalal H, Linton C, Rooney N: The use of the polymerase chain reaction in the diagnosis of B cell lymphomas from formalin fixed paraffin embedded tissue. Histopathology 1995, 26:333-338
32. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J: The 1993-94 genethon human genetic-linkage map. Nature Genet 1994, 7:246-339
33. Warnich L, Groenewald I, Theart L, Retief AE: Highly informative dinucleotide repeat polymorphism at the D11S29 locus on chromosome 11q23. Hum Genet 1992, 89:357-359
34. Telatar M, Concannon P, Tolun A: Dinucleotide repeat polymorphism at the NCAM locus. Hum Mol Genet 1994, 3:842
35. Hauge XY, Grandy DK, Eubanks JH, Evans GA, Civelli O, Litt M: Detection and characterization of additional DNA polymorphisms in the dopamine-D2 receptor gene. Genomics 1991, 10:527-530
36. Bedi A, Pasricha P, Akhtar A, Barber J, Bedi G, Giardiello F, Zehnbauer B, Hamilton S, Jones R: Inhibition of apoptosis during development of colorectal cancer. Cancer Res 1995, 55:1811-1816
37. Jass JR, Stewart SM, Stewart J, Lane MR: Hereditary non-polyposis colon cancer: morphologies, genes and mutations. Mutat Res 1994, 310:125-133
38. Jass JR: Colorectal adenomas in surgical specimens from subjects with hereditary non-polyposis colorectal cancer. Histopathology 1995, 27:263-267
39. Suzuki H, Harpaz N, Tarmin L, Yin J, Jiang HY, Bell JD, Hontanosas M, Groisman GM, Abraham JM, Meltzer SJ: Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers. Cancer Res 1994, 54:4841-4844
40. Yin J, Harpaz N, Tong Y, Huang Y, Laurin J, Greenwald BD, Hontanosas M, Newkirk C, Meltzer SJ: p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology 1993, 104:1633-1639
41. Brentnall TA, Crispin DA, Rabinovitch PS, Haggitt RC, Rubin CE, Stevens AC, Burmer GC: Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Gastroenterology 1994, 107:369-378
42. Befrits R, Hammarberg C, Rubio C, Jaramillo E, Tribukait B: DNA aneuploidy and histologic dysplasia in long-standing ulcerative colitis: a 10-year follow-up study. Dis Colon Rectum 1994, 37:313-319
43. Fozard JB, Quirke P, Dixon MF, Giles GR, Bird CC: DNA aneuploidy in ulcerative colitis. Gut 1986, 27: 1414-1418
44. Rubin CE, Haggitt RC, Burmer GC, Brentnall TA, Stevens AC, Levine DS, Dean PJ, Kimmey M, Perera DR, Rabinovitch PS: DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology 1992, 103:1611-1620
45. Carder P, Wyllie AH, Purdie CA, Morris RG, White S, Piris J, Bird CC: Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer. Oncogene 1993, 8:1397-1401
46. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994, 124:1-6