Inhibition of anti-Gal IgG binding to porcine endothelial cells by synthetic oligosaccharides

Transplantation

Volumn 62, Issue 2, 1996, Pages 256-262

  Galili, Uri ^a   Matta, Khushi L ^b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GALACTOSIDE; IMMUNOGLOBULIN G ANTIBODY; MELIBIOSE; OLIGOSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENDOTHELIUM CELL; GRAFT REJECTION; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SWINE; XENOGRAFT;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CARBOHYDRATE SEQUENCE; CELLS, CULTURED; ENDOTHELIUM; EPITOPES; GALACTOSE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; SWINE;

EID: 0029905427     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199607270-00018     Document Type: Article

References (31)

1. Galili U, Rachmilewitz EA, Peleg A, Flechner I. A unique natural human IgG antibody with anti-α-galactosyl specificity. J Exp Med 1984; 160: 1519.
2. Galili U, Clark MR, Shohet SB, Buehler J, Macher BA. Evolutionary relationship between the anti-Gal antibody and the Galα1→3Gal epitope in primates. Proc Natl Acad Sci USA 1987; 84: 1369.
3. Galili U, Macher BA, Buehler J, Shohet SB. Human natural anti-α-galactosyl IgG: II. The specific recognition of α(1→3)-linked galactose residues. J Exp Med 1985; 62: 573.
4. Galili U, Buehler J, Shohet SB, Macher BA. The human natural anti-Gal IgG: III. The subtlety of immune tolerance in man as demonstrated by crossreactivity between natural anti-Gal and anti-B antibodies. J Exp Med 1987; 165: 693.
5. Galili U, Shohet SB, Kobrin E, Stults CLM, Macher BA. Man, apes, and Old World monkeys differ from other mammals in the expression of α-galactosyl epitopes on nucleated cells. J Biol Chem 1988; 263: 17755.
6. Weislander J, Mannson O, Kallin E, Gabrielli A, Nowack H, Timpl R. Specificity of human antibodies against Galα1-3Gal carbohydrate epitope and distinction from natural antibodies reacting with Galα1-2Gal or Galα1-4Gal. Glycoconjugate J 1990; 7: 85.
7. Galili U, Gregory CR, Morris RE. Contribution of anti-Gal to primate and human IgG binding to porcine endothelial cells. Transplantation 1995; 60; 210.
8. Galili U. Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: a major obstacle for xenotransplantation in humans. Immunol Today 1993; 14; 480.
9. Good H, Cooper DKC, Malcolm AJK, et al. Identification of carbohydrate structures which bind human anti-porcine antibodies: implications for discordant grafting in man. Transplant Proc 1992; 24: 559.
10. Sandrin M, McKenzie IFC. Galα(1,3)Gal, the major xenoantigen(s) recognized in pigs by human natural antibodies. Immunol Rev 1994; 141: 169.
11. Collins BH, Cotterell AH, McCurry KR, et al. Cardiac xenografts between primate species provide evidence of the α-galactosyl determinant in hyperacute rejection. J Immunol 1994; 154: 5500.
12. Neethling FA, Koren E, Ye Y, et al. Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by α-galactosyl oligosaccharides. Transplantation 1994; 57: 959.
13. Parker W, Bruno O, Holzkecht ZE, Platt JE. Characterization and affinity isolation of xenoreactive human natural antibodies. J Immunol 1994; 153: 3791.
14. Vaughan HA, Loveland BE, Sandrin MS. Galα1,3Gal is the major xeno-epitope expressed on pig endothelial cells recognized by naturally occurring cytotoxic human antibodies. Transplantation 1994; 58: 879.
15. Koren E, Kujundzic M, Koscic M, et al. Cytotoxic effects of human preformed anti-Gal IgG and complement on cultured pig cells. Transplant Proc 1994; 26: 1336.
16. McCurry KR, Kooyman DL, Alvarado CG, et al. Human complement regulatory proteins protect swine to primate cardiac xenografts from human injury. Nature (Med) 1995; 1: 423.
17. Cozzi E, White DJG. The generation of transgenic pigs as potential organ donors for humans. Nature (Med) 1995; 1: 964.
18. Satake M, Kumagai-Braesch M, Kawagishi N, Tibell A, Groth CG, Moller E. Kinetics and characteristics of xenoantibody formation in diabetic patients transplanted with fetal porcine islet cell clusters. Xenotransplantation 1994; 1: 24.
19. Galili U, Tibell A, Samuelsson B, Rydberg L, Groth CG. Increased anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters. Transplantation 1995; 59: 1549.
20. Cooper DKC, Ye Y, Kehoe M, et al. A novel approach to "neutralization" of preformed antibodies: Cardiac allotransplantation across the ABO blood group barrier as a paradigm of discordant transplantation. Transplant Proc 1992; 24: 566.
21. Ye Y, Neethling FA, Niekrasz M, et al. Evidence that intravenously adminstered α-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts. Transplantation 1994; 58: 330.
22. Sarkar AK, Matta KL. 2,3,4,6-Tetra-O-benzyl-β-D-galactopyranosyl phenyl sulfoxide as a glycosyl donor: Synthesis of some oligosaccharides containing an α-D-galactopyranosyl group. Carbohydrate Res 1992; 233: 245.
23. Abbas SA, Barlow JJ, Matta KL. Synthesis of p-Nitrophenyl 3-α-β-D-Galactopyranosyl-β-D-Galactopyranoside and p-Nitrophenyl 3-O-α-D-Galactopyranosyl-β-D-Galactopyranoside. Carbohydrate Res 1982; 101: 231.
24. Henion TR, Macher BA, Anaraki F, Galili U. Defining the minimal size of catalytically active primate α1,3 galactosyltransferase: structure function studies on the recombinant truncated enzyme. Glycobiology 1994; 4: 193.
25. Wang L, Anaraki F, Henion TR, Galili U. Variations in activity of the human natural anti-Gal antibody in young and elderly populations. J Gerontol (Med Sci) 1995; 50A: M227.
26. Cooper DKC, Koren E, Oriol R. Oligosaccharides and discordant xenotransplantation. Immunol Rev 1994; 141: 31.
27. Neethling F, Joziasse D, Bovin N, Cooper DKC. The reducing end of α-Gal oligosaccharides may contribute to their efficiency in blocking natural antibodies of human and baboon sera. 3rd International Congress for Xenotransplantation 1995; abstract 11.
28. Cairns T, Lee J, Goldberg L, et al. Inhibition of the pig to human xenograft reaction using soluble Galα1-3Gal and Galα1-3Galβ1-4GlcNAc. Transplantation 1995; 60: 1202.
29. Thall AD, Maly P, Lowe JB. Oocyte Galα1-3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. J Biol Chem 1995; 270: 21437.
30. Tange MJ, Katerelos M, Crawford RJ, et al. Analysis of α1,3 galactosyltransferase knock-out mice. 3rd International Congress for Xenotransplantation 1995; abstract 51.
31. Elliott EA, Sandrin MA, Flavell RA, Matis LA, McKenzie IFC. A model for inhibiting hyperacute rejection: α1,3 galactosyltransferase "knock-out" mice. 3rd International Congress for Xenotransplantation 1995; abstract 180.