Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer

British Journal of Cancer

Volumn 74, Issue 10, 1996, Pages 1615-1619

  Van Den Berg, J ^a   Johannsson, O ^a   Hakansson S ^a   Olsson, H ^a   Borg, A ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allelic loss; BRCA2; Breast cancer; Prognosis; Retinoblastoma gene

Indexed keywords

DNA; DNA MARKER; ESTROGEN RECEPTOR; MICROSATELLITE DNA; PROGESTERONE RECEPTOR; RETINOBLASTOMA PROTEIN;

AGED; ARTICLE; BREAST CANCER; CANCER GENETICS; CANCER MORTALITY; CANCER RECURRENCE; CHROMOSOME 13Q; DNA CONTENT; FAMILIAL CANCER; FEMALE; GENE LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; TUMOR SUPPRESSOR GENE;

EID: 0029905138     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.597     Document Type: Article

References (21)

1. BORG Å, BALDETORP B, FERNÖ M, KILLANDER D, OLSSON H AND SIGURDSSON H. (1991). ERBB2 amplification in breast cancer with a high rate of proliferation. Oncogene, 6, 137-143.
2. BORG Å, ZHANG Q-X, ALM P, OLSSON H AND SELLBERG G. (1992). The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression. Cancer Res., 52, 2991-2994.
3. CLETON-JANSEN AM, COLLINS N, LAKHANI SR, WEISSENBACH J, DEVILEE P, CORNELISSE CJ AND STRATTON MR. (1995). Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13. Br. J. Cancer, 72, 1241-1244.
4. COLLINS N, MCMANUS R, WOOSTER R, MANGION J, SEAL S, LAKHANI SR, ORMISTON W, DALY PA, FORD D, EASTON DF AND STRATTON MR. (1995). Consistent loss of wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-q13. Oncogene, 10, 1673-1675.
5. DEVILEE P, VAN DEN BROEK M, KUIPERS-DIJKSHOORN N, KOLLURI R, KHAN PM, PEARSON PM AND CORNELISSE CJ. (1989). At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinomas. Genomics, 5, 554-560.
6. FERNÖ M, BALDETORP B, BORG Å, OLSSON H, SIGURDSSON H AND KILLANDER D. (1992). Flow cytometric DNA index and S-phase fraction in breast cancer in relation to other prognostic factors and to clinical outcome. Acta Oncol., 31, 157-165.
7. FUTREAL PA, LIU QY, SHATTUCKEIDENS D, COCHRAN C, HARSHMAN K, TAVTIGIAN S, BENNETT LM, HAUGENSTRANO A, SWENSEN J, MIKI Y, EDDINGTON K, MCCLURE M, FRYE C, WEAVERFELDHAUS J, DING W, GHOLAMI Z, SODERKVIST P, TERRY L, JHANWAR S, BERCHUCK A, IGLEHART JD, MARKS J, BALLINGER DG, BARRETT JC, SKOLNICK MH, KAMB A AND WISEMAN R. (1994). BRCA1 mutations in primary breast and ovarian carcinomas. Science, 266, 120-122.
8. GUDMUNDSSON J, JOHANNESDOTTIR G, BERGTHORSSON JT, ARASON A, INGVARSSON S, EGILSSON V AND BARKADOTTIR RB. (1995). Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13. Cancer Res., 55, 4830-4832.
9. GYAPAY G, MORISSETTE J, VIGNAL A, DIB C, FIZAMES C, MILLASSEAU P, MARC S, BERNARDI G, LATHROP M AND WEISSENBACH J. (1994). The 1992-94 Généthon human genetic linkage map. Nature Genet., 7, 246-339.
10. JOHANNSSON O, OSTERMEYER EA, HAKANSSON S, FRIEDMAN LS, JOHANSSON U, SELLBERG C, BRØNDUM-NIELSEN K, SELE V, OLSSON H, KING M-C AND BORG Å. (1996). Founding BRCA1 mutations in hereditary breast and ovarian cancer in southern Sweden. Am. J. Hum. Genet., 58, 441-450.
11. KERANGUEVEN F, ALLIONE F, NOGUCHI T, ADELAIDE J, SOBOL H, JACQUEMIER J AND BIRNBAUM D. (1995). Pattern of loss of heterozygositty at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast cancer. Genes Chrom. Cancer, 13, 291-294.
12. KNUDSEN A. (1993). Antioncogenes and human cancer. Proc. Natl Acad. Sci. USA, 90, 10914-10921.
13. MERAJVER SD, PHAM TM, CADUFF RF, CHEN M, POY EL, COONEY KA, WEBER BL, COLLINS FS, JOHNSTON C AND FRANK TS. (1995). Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. Nature Genet., 9, 439-443.
14. MIKI Y, SWENSEN J, SHATTUCKEIDENS D, FUTREAL PA, HARSHMAN K, TAVTIGIAN S, LIU QY, COCHRAN C, BENNETT LM, DING W, BELL R, ROSENTHAL J, HUSSEY C, TRAN T, MCCLURE M, FRYE C, HATTIER T, PHELPS R, HAUGENSTRANO A, KATCHER H, YAKUMO K, GHOLAMI Z, SHAFFER D, STONE S, BAYER S, WRAY C, BOGDEN R, DAYANANTH P, WARD J, TONIN P, NAROD S, BRISTOW PK, NORRIS FH, HELVERING L, MORRISON P, ROSTECK P, LAI M, BARRETT JC, LEWIS C, NEUHAUSEN S, CANNONALBRIGHT L, GOLDGAR D, WISEMAN R, KAMB A AND SKOLNICK MH (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science, 266, 66-71.
15. SCHOTT DR, NGO CHANG J, DENG G, KURISU W, KUO W-L, GRAY J AND SMITH H. (1994). A candidate tumour suppressor gene in human breast cancers. Cancer Res., 54, 1393-1396.
16. SMITH SA, EASTON DF, EVANS DGR AND PONDER BAJ. (1992). Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome. Nature Genet., 2, 128-131.
17. TAVTIGIAN SV, SIMARD J, ROMMENS J, COUCH F, SHATTUCKEIDENS D, NEUHAUSEN S, MERAJVER S, THORLACIUS S, OFFIT K, STOPPA-LYONNET, D, BELANGER C, BELL R, BERRY S, BOGDEN B, CHEN Q, DAVIS T, DUMONT M, FRYE C, HATTIER J, JAMMULAPATI S, JANECKIT, JIANG P, KEHRER R, LEBLANC J-F, MITCHELL JT, MCARTHUR-MORRISON J, NGUYEN K, PENG Y, SAMSON C, SCHROEDER M, SNYDER SC, STEELE L, STRINGFELLOW M, TENG D, THOMAS A, TRAN T, TRAT T, TRANCHANT M, WEAVER-FELDHAUS J, WONG AKC, SHIZUYA H, EYFJORD JE, CANON-ALBRIGHT L, LABRE F, SKOLNICK MH, WEBER B, KAMB A AND GOLDBAR DE. (1996). The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet., 12, 333-337.
18. THOMPSON ME, JENSEN RA, OBERMILLER PS, PAGE DL AND HOLT JT. (1995). Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nature Genet., 9, 444-450.
19. VARLEY J, ARMOUR J, SWALLOW J, JEFFREYS A, PONDER B, T'ANG A, FUNG Y-K, BRAMMAR W AND WALKER R. (1989). The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. Oncogene, 4, 725-729.
20. WOOSTER R, NEUHAUSEN SL, MANGION J, QUIRK Y, FORD D, COLLINS N, NGUYEN K, SEAL S, TRAN T, AVERILL D, FIELDS P, MARSHALL G, NAROD S, LENOIR GM, LYNCH H, FEUNTEUN J, DEVILEE P, CORNELISSE CJ, MENKO FH, DALY PA, ORMISTON W, MCMANUS R, PYE C, LEWIS CM, CANNONALBRIGHT LA, PETO J, PONDER BAJ, SKOLNICK MH, EASTON DF, GOLDGAR DE AND STRATTON MR. (1994). Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science, 265, 2088-2090.
21. WOOSTER R, BIGNELL G, LANCASTER J, SWIFT S, SEAL S, MANGION J, COLLINS N, GREGORY S, GUMBS C, MICKLEM G, BAREFOOT R, HAMOUDI R, PATEL S, RICE C, BIGGS P, HASHIM Y, SMITH A, CONNOR F, ARASON A, GUDMUNDSSON J, FICENEC D, KELSELL D, FORD D, TONIN P, BISHOP DT, SPURR NK, PONDER BAJ, EELES R, PETO J, DEVILEE P, CORNELISSE C, LYNCH H, NAROD S, LENOIR G, EGILSSON V, BJORK BARKADOTTIR R, EASTON DF, BENTLEY OR, FUTREAL PA, ASHWORTH A AND STRATTON MR. (1995). Identification of the breast cancer susceptibility gene BRCA2. Nature, 378, 789-792.