On the trough-to-peak ratio of drug effect in antihypertensive trials

American Journal of Hypertension

Volumn 9, Issue 10 PART I, 1996, Pages

  Fenichel, Robert R ^a   Lipicky, Raymond J ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Antihypertensive drug trials; Drug effectiveness; Food and Drug Administration; Time course of drug effect; Trough to peak effect

Indexed keywords

ANTIHYPERTENSIVE AGENT;

ANTIHYPERTENSIVE THERAPY; CONFERENCE PAPER; DRUG BLOOD LEVEL; DRUG EFFECT; FOOD AND DRUG ADMINISTRATION; HEMODYNAMIC MONITORING; HUMAN; HYPERTENSION; PRIORITY JOURNAL;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CLINICAL TRIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPERTENSION;

EID: 0029905051     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/0895-7061(96)00272-5     Document Type: Article

References (2)

1. Proposed Guidelines for the Clinical Evaluation of Antihypertensive Drug Products (Draft). FDA Division of Cardio-Renal Drug Products, Rockville, MD, 9 May 1988, p 4.
2. Transcript of the 56th Meeting of the Cardiovascular and Renal Drugs Advisory Committee, 3 November 1988. Food and Drug Administration, Rockville, MD, 1988, pp 166-175.