New methodologies for pharmacological treatment trials for alcohol dependence

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 7 SUPPL., 1996, Pages

  Anton, Raymond F ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MUSC Center for Drug and Alcohol Programs   (United States)

Author keywords

Carbohydrate Deficient Transferrin (CDT); Medication Compliance; Outcome Measurements; Population Selection

Indexed keywords

BUSPIRONE; NALTREXONE; RIBOFLAVIN;

ALCOHOL CONSUMPTION; ALCOHOLISM; CONFERENCE PAPER; DIAGNOSTIC VALUE; DRUG MONITORING; HUMAN; PATIENT COMPLIANCE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0029904526     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01183.x     Document Type: Conference Paper

References (56)

1. Linnoila M, Fawcett J, Fuller RK, Harford TC, Martin PB, Meyer RE, Romach MK, Sellers EM: Evaluation of pharmacologic treatments for alcohol abuse, dependence, and their complications, in Prien RF, Robinson DS (eds): Clinical Evaluation of Psychotropic Drugs: Principles and Guidelines. New York, Raven Press, 1994, pp 625-649
2. Grant BF, Harford TC, Chou P, Pickering R, Dawson DA, Stinson FS, Noble J: Prevalence of DSM-III-R alcohol abuse and dependence: United States, 1988 (Epidemiologic Bulletin no. 27). Alcohol Health Res World 15:91-96, 1991
3. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK: Comorbidity of mental disorders with alcohol and other drug abuse: Results from the epidemiologic catchment area (ECA) study. JAMA 264:2511-2518, 1990
4. Eckardt MJ, Harford TC, Kaelber CT, Parker ES, Rosenthal LS, Ryback RS, Salmoiraghi GC, Vanderveen E, Warren KR: Health hazards associated with alcohol consumption. JAMA 246:648-666, 1981
5. Stinson FS, Williams GD, Bertolucci D, Noble J: Alcohol-related morbidity, 1979-1984 (Epidemiologic Bulletin No. 14). Alcohol Health Res World 11:56-61, 1987
6. Centers for Disease Control: Alcohol-related mortality and years of potential life lost - United States, 1987. MMWR 39:173-178, 1990
7. Fuller RK, Branchey L, Brightwell DR, Derman RM, Emrick CD, Iber FL, James KE, Lacoursiere RB, Lee KK, Lowenstam I, Maany I, Neiderhiser D, Nocks JJ, Shaw S: Disulfiram treatment of alcoholism: A Veterans Administration Cooperative Study. JAMA 256:1449-1455, 1986
8. Anton RF: Medications for treating alcoholism. Alcohol Health Res World 18:265-271, 1994
9. Anton RF: New direction in the pharmacotherapy of alcoholism. Psychiatr Ann 25:353-362, 1995
10. Kranzler HR, Anton RF: Implications of recent neuropharmacologic research for understanding the etiology and development of alcoholism. J Consult Clin Psychol 62:1116-1126, 1994
11. Kranzler HR, Mason BJ, Pettinati H, Anton RF: Methodological issues in clinical trials with alcoholics, in Hertzman M, Feltner D (eds): Clinical Trials of CNS Drugs. New York, New York University Press (in press)
12. Moak DH, Anton RF, Malcolm R, Randall CL, Brady K: Alcoholic subjects with anxiety disorder: Characteristics of completers and noncompleters in a pharmacologic study. Am J Addict 2:39-47, 1993
13. Taylor WC, Obitz FW, Reich JW: Experimental bias resulting from using volunteers in alcoholism research. J Stud Alcohol 43:240-251, 1982
14. Strohmetz DB, Alterman AI, Walter D: Subject selection bias in alcoholics volunteering for a treatment study. Alcohol Clin Exp Res 14:736-738, 1990
15. McLellan AT, Luborsky L, Woody GE, O'Brien CP, Druley KA: Predicting response to alcohol and drug abuse treatments: Role of psychiatric severity. Arch Gen Psychiatry 40:620-625, 1983
16. Ross HE, Glaser FB, Germanson T: The prevalence of psychiatritc disorders in patients with alcohol and other drug problems. Arch Gen Psychiatry 45:1023-1031, 1988
17. Dorus W, Ostrow DG, Anton R, Cushman P, Collins JF, Schaefer M, Charles HL, Desai P, Hayashida M, Malkerneker U, Willenbring M, Fiscella R, Sather MR: Lithium treatment of depressed and nondepressed alcoholics. JAMA 262:1646-1652, 1989
18. Fawcett J, Clark DC, Aagesen CA, Pisani VD, Tilkin JM, Sellers D, McGuire M, Gibbons RD: A double-blind, placebo-controlled trial of lithium carbonate therapy for alcoholism. Arch Gen Psychiatry 44:248- 256, 1987
19. De la Fuente JR, Morse RM, Niven NG, Ilstrup DM: A controlled study of lithium carbonate in the treatment of alcoholism. Mayo Clin Proc 64:177-180, 1989
20. Merry J, Reynolds CM, Bailey J, Coppen A: Prophylactic treatment of alcoholism by lithium carbonate. Lancet 1:481-482, 1976
21. Kline NS, Wren JC, Cooper TB, Varga E, Canal O: Evaluation of lithium therapy in chronic and periodic alcoholism. Am J Med Sci 268: 15-20, 1974
22. Freiman JA, Chalmers TC, Smith H Jr, Kuebler RR: The importance of beta, the type II error and sample size in the design and interpretation of the randomized controlled trial: Survey of 71 "negative" trials. N Engl J Med 299:690-694, 1978
23. Anton RF: New methodologies in clinical pharmacologic trials of alcoholism. Presented at the Research Society on Alcoholism Annual Meeting, June 23, 1994, Maui, HI
24. Spriet A, Simon P: Methodology of Clinical Drug Trials (translated by Edelstein R, Weintraub M). Basel, Karger Publishers, 1985, pp 127-135
25. Spilker B: Guide to Clinical Trials. New York, Raven Press, 1991, pp 102-114
26. Young LM, Haakenson CM, Lee KK, van Eeckhout JR: Riboflavin use as a drug marker in veterans administration cooperative studies. Controlled Clin Trials 5:497-504, 1984
27. Lambert WE, Cammaert PM, De Leenheer AP: Liquid-chromatographic measurement of riboflavin in serum and urine with isoriboflavin as internal standard. Clin Chem 31:1371-1373, 1985
28. Babiker IE, Cooke PR, Gillett MG: How useful is riboflavin as a tracer of medication compliance? J Behav Med 12:25-38, 1989
29. Malcolm R, Anton RF, Randall CL, Johnston A, Brady K, Thevos A: A placebo-controlled trial of buspirone in anxious inpatient alcoholics Alcohol Clin Exp Res 16:1007-1013, 1992
30. Kranzler HR, Burleson JA, Del Boca FK, Babor TF, Korner P, Brown J, Bonn MJ: Buspirone treatment of anxious alcoholics: A placebo- controlled trial. Arch Gen Psychiatry 51:720-731, 1994
31. Helzer JE, Robins LN, Taylor JR, Carey K, Miller RH, Combs- Orme T, Farmer A: The extent of long-term moderate drinking among alcoholics discharged from medical and psychiatric facilities. N Engl J Med 312:1678-1682, 1985
32. Polich JM, Armor DJ, Braiker HB: Stability and change in drinking patterns, in The Course of Alcoholism; Four Years After Treatment. New York, John Wiley and Sons, 1981, pp 159-200
33. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP: Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880, 1992
34. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence. Arch Gen Psychiatry 49:881-887, 1992
35. Ludwig AM: Understanding the Alcoholic's Mind. New York, Oxford University Press, 1988, pp 33-48
36. O'Connor PG, Gottlieb LD, Kraus ML, Segal SR, Horwitz RI: Social and clinical features as predictors of outcome in outpatient alcohol withdrawal. J Gen Intern Med 6:312-316, 1991
37. Modell JG, Glaser FB, Cyr L, Mountz JM: Obsessive and compulsive characteristics of craving for alcohol in alcohol abuse and dependence. Alcohol Clin Exp Res 16:272-274, 1992
38. Modell JG, Glaser FB, Mountz JM, Schmaltz S, Cyr L: Obsessive and compulsive characteristics of alcohol abuse and dependence: Quantification by a newly developed questionnaire. Alcohol Clin Exp Res 16:266-271, 1992
39. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS: The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 46:1006-1011, 1989
40. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR, Charney DS: The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry 46:1012-1016, 1989
41. Anton RF, Moak DH, Catham P: The obsessive compulsive drinking scale: A self rated instrument for the quantification of thoughts about alcohol and drinking behavior. Alcohol Clin Exp Res 19:92-99, 1995
42. Anton RF, Moak DH, Latham PK: The Obsessive Compulsive Drinking Scale (OCDS): A new method of assessing outcome in alcoholism treatment studies. Arch Gen Psychiatry 53:225-231, 1996
43. Orrego H, Blendis LM, Blake JE, Kapur BM, Israel Y: Reliability of assessment of alcohol intake based on personal interviews in a liver clinic. Lancet 1:1354-1356, 1979
44. Sobell MB, Sobell LC, VanderSpek R: Relationships among clinical judgment, self-report, and breath-analysis measures of intoxication in alcoholics. J Consult Clin Psychol 47:204-206, 1979
45. Fuller RK, Lee KK, Gordis E: Validity of self-report in alcoholism research: Results of a Veterans Administration Cooperative Study. Alcohol Clin Exp Res 12:201-205, 1988
46. Rosman AS, Lieber CS: Biochemical markers of alcohol consumption. Alcohol Health Res World 14:210-218, 1990
47. Allen JP, Litten RZ, Anton RF. Measures of alcohol consumption in perspective, in Litten RZ, Allen JP (eds): Measuring Alcohol Consumption: Psychosocial and Biologic Methods. Totowa, NJ, Humana Press, 1992
48. Mihas AA, Tavassoli M: Laboratory markers of ethanol intake and abuse: A critical appraisal. Am J Med Sci 303:415-428, 1992
49. Irwin M, Baird S, Smith TL, Schuckit M: Use of laboratory tests to monitor heavy drinking by alcoholic men discharged from a treatment program. Am J Psychiatry 145:595-599, 1988
50. Stibler H: Carbohydrate-deficient transferrin in serum: A new marker of potentially harmful alcohol consumption reviewed. Clin Chem 37:2029-2037, 1991
51. Allen JP, Litten RZ, Anton RF, Cross GM: Carbohydrate-deficient transferrin as a measure of immoderate drinking: Remaining issues. Alcohol Clin Exp Res 18:799-812, 1994
52. Anton RF, Moak DH: Carbohydrate-deficient transferrin and γ-glutamyltransferase as markers of heavy alcohol consumption: Gender differences. Alcohol Clin Exp Res 18:747-754, 1994
53. Stibler H, Borg S, Joustra M: Micro anion exchange chromatography of carbohydrate-deficient transferrin in serum in relation to alcohol consumption (Swedish patent 8400587-5). Alcohol Clin Exp Res 10:535- 544, 1986
54. Xin Y, Rosman AS, Lasker JM, Lieber CS: Measurement of carbohydrate-deficient transferrin by isoelectric focusing/western blotting and by micro anion-exchange chromatography/radioimmunoassay: Com- parison of diagnostic accuracy. Alcohol Alcohol 27:425-433, 1992
55. Anton R, Bean P: Comparison of two methods of carbohydrate-deficient transferrin (CDT) measurement in inpatient alcoholics and healthy controls. Clin Chem 40:364-368, 1994
56. Anton RF, Moak DH, Latham PK: Carbohydrate-deficient transferrin as an indicator of drinking status. Alcohol Clin Exp Res 20:841-846, 1996