Aromatase cytochrome P450 gene expression in endometrial carcinoma

British Journal of Cancer

Volumn 74, Issue 10, 1996, Pages 1541-1544

  Sasano, H ^a   Kaga, K ^a   Sato, S ^a   Yajima, A ^a   Nagura, H ^c   Harada, N ^b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c School of Medicine ^*

Author keywords

Aromatase; Endometrium; Oestrogen

Indexed keywords

AROMATASE; CYTOCHROME P450;

ALTERNATIVE RNA SPLICING; ARTICLE; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; FIBROBLAST; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0029904509     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.586     Document Type: Article

References (17)

1. BULUN SE, MAHENDROO MS AND SIMPSON ER. (1993). Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua. J. Clin. Endocrinol. Metab., 76, 1458-1463.
2. BULUN SE AND SIMPSON ER. (1994a). Regulation of aromatase expression in human tissues. Breast Cancer Res. Treat., 30, 19-29.
3. BULUN SE, SIMPSON ER AND WORD RA. (1994b). Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture. J. Clin. Endocrinol. Metab., 78, 736-743.
4. BULUN SE, ECONOMOS K, MILLER D AND SIMPSON ER. (1994c). CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors. J. Clin. Endocrinol. Metab., 78, 736-743.
5. CHIRGWIN JM, PRZYBLA AE, MCDONALD KJ AND UTTER WJ. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299.
6. CREASEMAN WT. (1989). Announcement of FIGO stages: 1988 revisions. Gynecol. Oncol., 35, 125-127.
7. HARADA N. (1988). Novel properties of human placental aromatase as cytochrome P450 purification and characterization of a unique form of aromatase. J. Biochem., 103, 106-112.
8. HARADA N AND YAMADA K. (1992a). Ontogeny of aromatase messenger ribonucleic acid in mouse brain: fluorometrical quantitation by polymcrasc chain reaction. Endocrinology, 131, 2306-2312.
9. HARADA N, YAMADA K, FOIDART A AND BALTHAZART J. (1992b). Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone. Mol. Brain Res., 15, 19-26.
10. HARADA N, UTSUMI T AND TAKAGI Y. (1993). Tissue-specific expression of the human aromatase cylochrome p-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons I in carcinogenesis. Proc. Natl Acad. Sci. USA, 90, 11312-11316.
11. HARADA N, UTSUMI T AND TAKAGI Y. (1996). Molecular and epidemiological analysis of abnormal expression of aromatase in breast cancer. Pharmacogenetics. (in press).
12. MAHENDROO MS, MEANS GD, MENDELSON CR AND SIMPSON ER. (1991). Tissue-specific expression of human P450arom: the promoter responsible for expression in adipose tissue is different from that utilized in placenta. J. Biol. Chem., 266, 11276-11281.
13. MEANS GD, MAHENDROO MS AND CORBIN CJ. (1988). Structural analysis of the gene encoding aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J. Biol. Chem., 264, 19385-19391.
14. MEANS GD, KILGORE MW, MAHENDROO MS, MENDELSON CR AND SIMPSON ER. (1991). Tissue-specific promoters regulate aromatuse cytochrome P-450 gene expression in human ovary and fetal tissues. Mol. Endocrinol., 5, 2005-2013.
15. SASANO H, NAGURA H, HARADA N, GOUKON Y AND KIMURA M. (1994). Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum. Pathol., 25, 530-535.
16. SILVERBERG SG AND KURMAN RJ. (199). Tumors of the uterine corpus and gestational trophoblastic disease. In Atlas of Tumor Pathology, Rosai J (ed.) pp. 47-83. Armed Forces Institute of Pathology: Washington DC.
17. WATANABE K, SASANO H, HARADA N, SATO S AND YAJIMA A. (1995). Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. Am. J. Pathol., 146, 491-500.