Induction of passive Heymann nephritis with antibodies specific for a synthetic peptide derived from the receptor-associated protein

Journal of Experimental Medicine

Volumn 183, Issue 5, 1996, Pages 2007-2015

  Kerjaschki, Dontscho ^a   Ullrich, Robert ^a   Exner, Marcus ^a   Orlando, Robert A ^b   Farquhar, Marilyn G ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; RECEPTOR PROTEIN; SYNTHETIC PEPTIDE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; GLOMERULUS BASEMENT MEMBRANE; HEYMANN NEPHRITIS; IMMUNE COMPLEX DEPOSITION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; AUTOANTIGENS; CARRIER PROTEINS; COATED PITS, CELL-MEMBRANE; EPITOPES; GLOMERULONEPHRITIS; GLYCOPROTEINS; HEYMANN NEPHRITIS ANTIGENIC COMPLEX; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOGLOBULIN G; KIDNEY GLOMERULUS; LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN; MALE; MEMBRANE GLYCOPROTEINS; MICROSCOPY, IMMUNOELECTRON; MODELS, STRUCTURAL; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RABBITS; RATS; RATS, INBRED LEW; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0029904111     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.5.2007     Document Type: Article

References (24)

1. Clayton, J.P., G.M. Gammon, D.G. Ando, D.H. Kono, L. Hood, and E.E. Sercarz. 1989. Peptide-specific prevention of experimental allergic encephalomyelitis. J. Exp. Med. 169: 1681-1691.
2. Zamvil, S.S., D.J. Mitchell, A.C. Moore, L. Kitamura, L. Steinmann, and J.B. Rothbard. 1986. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature (Lond.). 324:258-269.
3. Schwartz, M.M. 1992. Membranous glomerulonephritis. In Pathology of the Kidney. R.H. Heptinstall, editor. Little, Brown and Co., Boston, MA. 559-626.
4. Andres, G., J.R. Brentjens, P.R.B. Caldwell, G. Camussi, and S. Matsuo. 1986. Biology of disease: formation of immune deposits and disease. Lab Invest. 55:510-520.
5. Farquhar, M.G, A. Saito, D. Kerjaschki, and R. Orlando. 1995. The Heymann nephritis antigenic complex: megalin (gp330) and RAP. J. Am. Soc. Nephrol. 6:35-47.
6. Kerjaschki, D., A. Miettinen, and M.G. Farquhar. 1987. Initial events in the formation of IDs in passive Heymann nephritis: Gp330-anti gp330 immune complexes form in epithelial coated pits and rapidly become attached to the GBM. J. Exp. Med. 166:109-128.
7. Kerjaschki, D., and M.G. Farquhar. 1982. Identification of a membrane glycoprotein from kidney brush border as the pathogenic antigen of Heymann's nephritis. Proc. Natl. Acad. Sci. USA. 79:5557-5561.
8. Saito, A., S. Pietromonaco, A.K.C. Loo, and M.G. Farquhar. 1994. Complete cloning and sequencing of rat gp330/megalin, a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA. 91:9725-9729.
9. Farquhar, M.G., D. Kerjaschki, M. Lundstrom, and R. Orlando. 1994. Gp330 and RAP: the Heymann nephritis antigenic complex. Ann. NY Acad. Sci. 737:96-113.
10. Williams, S.E., M.Z. Kounnas, L.M. Argraves, S. Argraves, and D.K. Strickland. 1994. The α2-macroglobulin receptor/low density lipoprotein receptor related protein and the receptor associated protein: an overview. Ann. NY Acad. Sci. 739:1-13.
11. Pietromonaco, S.D., D. Kerjaschki, S. Binder, R. Ullrich, and M.G. Farquhar. 1990. Molecular cloning of a cDNA encoding a major pathogenic domain of the Heymann nephritis antigen gp330. Proc. Natl. Acad. Sci. USA. 87:1811-1815.
12. Kerjaschki, D., R. Ullrich, S. Pietromonaco, K. Diem, R.A. Orlando, and M.G. Farquhar. 1992. Identification of a pathogenic epitope involved in the initiation of Heymann nephritis. Proc. Natl. Acad. Sci. USA. 89:11179-11183.
13. Tam, J.P. 1988. Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc. Natl. Acad. Sci. USA. 85:5409-5413.
14. McLean, J.W., and P.K. Nakane. 1974. Periodate-lysine-paraformaldehyde fixative: a new fixative for electron microscopy. J. Histochem. Cytochem. 22:1077-1083.
15. Neale, T.J., P.P, Ojha, M. Exner, H. Poczewski, B. Rueger, J.L. Witztum, P. Davis, and D. Kerjaschki. 1994. Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. J. Clin. Invest. 94:1577-1584.
16. Rost, B., and C. Sander. 1993. Prediction of protein structure at better than 70% accuracy. J. Mol. Biol. 232:584-599.
17. Zhao, W., K.W. Wegmann, J.L. Trotter, K. Ueno, and W.F. Hickey. 1994. Identification of an N-terminally acetylated encephalitogenic epitope in myelin proteolipid apoprotein for Lewis rats. J. Immunol. 153:901-909.
18. Orlando, R.A., D. Kerjaschki, H. Kurihara, D. Biemensderfer, and M.G. Farquhar. 1992. gp330 associates with a 44-kD protein in the rat kidney to form the Heymann nephritis antigenic complex. Prof. Natl. Acad. Sci. USA. 89:6698-6702.
19. Huang, J., and S.P. Makker. 1995. Role of receptor-associated 39/45 kD protein in active Heymann nephritis. Kidney Int. 47:432-441.
20. Muro, Y., W.M. Tsai, R. Houghten, and E.M. Tan. 1994. Synthetic compound peptide stimulating antigenicity of conformation-dependent autoepitope. J. Biol. Chem. 269:18529-18534.
21. Orlando, R.A., D. Kerjaschki, and M.G. Farquhar. 1995. Megalin (gp330) possesses antigenic epitopes capable of inducing passive Heymann nephritis independent of the nephritogenic epitope on RAP. J. Am. Soc. Nephrol. 6:61-67.
22. Saito, A., R. Ullrich, D. Kerjaschki, and M.G. Farquhar. 1995. Mapping pathogenic epitopes of rat megalin (gp330), a major Heymann nephritis antigen. J. Am. Soc. Nephrol. 6:853 (Abstr.).
23. Susani, M., M. Schulze, M. Exner, and D. Kerjaschki. 1994. Antibodies to glycolipids activate complement and promote proteinuria in passive Heymann nephritis. Am. J. Pathol. 144: 807-819.
24. Neilson, E.G., M.J. Sun, C.J. Kelly, W.H. Hines, T.P. Haverty, M.D. Clayman, and N.E. Cooke. 1991. Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease. Proc. Natl. Acad. Sci. USA. 88:2006-2010.