Sensory neurophysiology of the cough reflex

Journal of Allergy and Clinical Immunology

Volumn 98, Issue 5 SUPPL., 1996, Pages

  Widdicombe, John G ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

C fiber receptors; Capsaicin; Cough; Cough receptors; Neuropeptides; Rapidly adapting receptors; Tachykinins

Indexed keywords

NEUROPEPTIDE; SUBSTANCE P; TACHYKININ;

BRONCHUS REACTIVITY; CONFERENCE PAPER; COUGHING; HUMAN; PRIORITY JOURNAL; SENSORY NERVE; VAGUS NERVE; VAGUS REFLEX;

AFFERENT PATHWAYS; COUGH; HUMANS; REFLEX;

EID: 0029903782     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)70021-0     Document Type: Article

References (40)

1. Korpas J, Tomori Z. Cough and other respiratory reflexes. 12th ed. Basel: S. Karger, 1979:1-356.
2. Karlsson J-A, Sant'Ambrogio G, Widdicombe JG. Afferent neural pathways in cough and reflex bronchoconstriction. J Appl Physiol 1988;65:1007-23.
3. Widdicombe JG. Neurophysiology of the cough reflex. Eur Respir J 1995;8:1193-202.
4. Stockwell M, Lang S, Yip R, Zintel T, White C, Galagher CG. Lack of importance of the superior laryngcal nerves in citric acid cough in humans. J Appl Physiol 1993;75: 613-7.
5. Forsberg K, Karlsson JA, Lundberg JM, Zackrisson C. Effect of laryngeal denervation on irritant induced cough and bronchoconstriction in conscious guinea-pig [abstract]. J Physiol 1990;422:34P.
6. Coleridge HM, Coleridge JCG. Reflexes evoked from the tracheobronchial tree and lungs. In: Cherniack NS, Widdicombe JG, editors. Handbook of physiology, section 3. The respiratory system, vol. II. Control of breathing, part 1. Bethesda: American Physiological Society, 1986:395-429.
7. Widdicombe JG. Receptors in the trachea and bronchi of the cat. J Physiol 1954;123:71-104.
8. Das RM, Jeffery PK, Widdicombe JG. The epithelial innervation of the lower respiratory tract of the cat. J Anat 1978;126:123-31.
9. Baluk P, Nadel JA, McDonald DM. Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation. J Comp Neurol 1992;319:586-98.
10. Baluk P, Nadel JA, McDonald DM. Calcitonin generelated peptide in secretory granules of serous cells in the rat tracheal epithelium. Am J Respir Cell Mol Biol 1993; 8:446-53.
11. McDonald DM. The concept of neurogenic inflammation in the respiratory tract. In: Kaliner MA, Barnes PJ, Kunkel GHH, Baraniuk JN, editors. Neuropeptides in respiratory medicine. New York: Marcel Dekker, 1994:321-49.
12. Das RM, Jeffery PK, Widdicombe JG. Experimental degeneration of intraepithelial nerve fibres in cat airways. J Anat 1979;128:259-63.
13. Widdicombe JG. Respiratory reflexes from the trachea and bronchi of the cat. J Physiol 1954;123:55-70.
14. Gaylor JB. The intrinsic nervous mechanism of the human lung. Brain 1934;57:143-60.
15. Tatar M, Sant'Ambrogio G, Sant'Ambrogio FB. Laryngeal and tracheobronchial cough in anaesthetized dugs. J Appl Physiol 1994;76:2672-9.
16. Coleridge JCG, Coleridge HM. Afferent vagal C-flbre innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol 1984;99:1-110.
17. Tatar M, Webber SE, Widdicombe JG. Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats. J Physiol 1988;402:411-20.
18. Jackson DM. The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid induced cough in dogs. Br J Pharmacol 1988;93:609-12.
19. Jackson DM, Norris AA, Eady RP. Nedocromil sodium and sensory nerves in the dog lung. Pulm Pharmacol 1989;2: 179-84.
20. Stone RA, Worsdell Y-M, Fuller RW, Barnes PJ. Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex. J Appl Physiol 1993;74: 396-401.
21. Armstrong DJ, Luck JC. A comparative study of irritant and type J receptors in the cat. Respir Physiol 1974;21:47-60.
22. 2 on airway sensory receptors of anaesthetized cals. J Physiol 1993;469:51-66.
23. Winning AJ, Hamilton RD, Shea SA, Guz A. Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: evidence for pulmonary chemosensitivity. Clin Sci 1986;71:519-26.
24. Forsberg K, Karlsson J-A, Theodorssont E, Lundberg JM, Persson CGA. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm Pharmacol 1988;1:33-9.
25. Karlsson JA. A role for capsaicin positive, tachykinin containing nerves in chronic coughing and sneezing, but not in asthma: a hypothesis. Thorax 1993;48:396-400.
26. Jancso G. Pathobiological reactions of C-fibre primary sensory neurones to peripheral nerve injury. Exp Physiol 1992;77:405-31.
27. Prabhakar NR, Renuld M, Yamamoto Y, Lagererantz H, Cherniack NS, von Euler C. Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits. Acta Physiol Scand 1987;131:63-71.
28. Fox AJ, Barnes PJ, Urban L, Dray A. An in vitro study of the properties of single vagal afferents innervating guineapig airways. J Physiol 1993;46:21-35.
29. Myers AC, Riccio MM, Undem BJ. Effect of nedocromil sodium on neurogenic mechanisms in vitro. J Allergy Clin Immunol 1996;98:S107-11.
30. Kohrogi H, Graf PD, Sekizawa K, Borson DB, Nadel JA. Neutral endopeptidase inhibitors potentiate substance P and capsaicin-induced cough in awake guinea pigs. J Clin Invest 1988;82:2063-8.
31. Takahama K, Fuchikama T, Isohama Y, Kai H, Miyata T. Neurokinin A but not ncurokinin B and substance P induces codeine-resistance coughs in awake guinea-pigs. Regul Pept 1993;42:236-7.
32. Sckizawa K, Ebihara T, Sasaki H. Role of substance P in cough during bronchoconstriction in awake guinea pigs. Am J Respir Crit Care Med 1995;151:815-21.
33. Katsumata U, Sekizawa K, Inoue H, Sasaki H, Takishima T. Inhibitory actions of procaterol, a beta-2 stimulant, on substance P-induced cough in normal subjects during upper respiratory tract infection. Tohoku J Exp Med 1989;158: 105-6.
34. Ichinosc M, Nakajima N, Takahashi T, Yamanchi H, Inoue H, Takishima T. Protection against bradykinin induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist. Lancet 1992;340:1248-51.
35. Joos GF, Pauwels RA, Van Der Straeten ME. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax 1987;42:779-83.
36. 2 receptor antagonist. Eur J Pharmacol 1992;250:169-73.
37. Ujiie Y, Sekizawa K, Aikawa T, Sasaki H. Evidence for substance P as an endogenous substance causing cough in guinea pigs. Am Rev Respir Dis 1993;148:1628-32.
38. Morice AH, Lowry R, Brown MJ, Higenbottam T. Angiotensin-converting enzyme and the cough reflex. Lancet 1987;14:1116-8.
39. Laitinen A. Adtonomic innervation of the human respiratory tract as revealed by histochemical and ultrastructural methods. Eur J Respir Dis 1985;140:1-42.
40. Barnes PJ. Airway NANC nerves and neuropeptides. In: Barnes PJ, Rodger IW, Thomson NC, editors. Asthma: basic mechanisms and clinical management. London: Academic Press, 1992:359-89.