Epigenetic modification of transgenes under the control of the mouse mammary tumor virus LTR: Tissue-dependent influence on transcription of the transgenes

Biological Chemistry

Volumn 377, Issue 11, 1996, Pages 711-719

  Betzl, Gisela ^a   Brem, Gottfried ^b   Weidle, Ulrich H ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

DNA methylation; Heterologous gene expression; Transgenic animals; Urokinase and urokinase receptor

Indexed keywords

MESSENGER RNA; RECEPTOR; UROKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; KIDNEY; LIVER; LONG TERMINAL REPEAT; MAMMARY GLAND; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; RECOMBINANT GENE; SPLEEN; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALIA; MAMMARY TUMOR ONCOVIRUS; MAMMARY TUMOR VIRUS; MOUSE MAMMARY TUMOR VIRUS; MURINAE; MURINE MAMMARY TUMOR VIRUS; MUS MUSCULUS; ONCOVIRINAE; TUMOR VIRUS;

EID: 0029903742     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/bchm3.1996.377.11.711     Document Type: Article

References (41)

1. Adams.J.M., and Cory, S. (1991). Transgenic models of tumor development. Science 254, 1161 - 1167.
2. Allen, N.D., Norris, M.L., and Surani, M.A. (1990). Epigenetic control of transgene expression and imprinting by genotype-specific modifiers. Cell 61, 853 - 861.
3. Behrendt, N., Rønne, E., Ploug, M., Petri, T., Løber, D., Nielsen, L.S., Schleuning, W.D., Blasi, F, Appella, E., and Danø, K. (1990). The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants. J. Biol. Chem. 265, 6453 - 6460.
4. Brem, G., Brenig, B., Goodman, H.M., Selden, R.C., Graf, F., Kruff, B.,Springmann, K., Meyer, J., Winnacker, E.L., and Kräusslich, H. (1985). Production of transgenic mice rabbits and pigs by microinjection into pronuclei. Zuchthygiene 20, 251 - 252.
5. Brinster, R.L., Allen, J.M., Behringer, R.R., Gelinas, R.E., and Palmiter, R.D. (1988). Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad Sci. USA 85, 836 - 840.
6. Chaillet, J.R. (1994). Genomic imprinting: lessons from mouse transgenes. Mutation Res. 307, 441 - 449.
7. Challita, P.M., and Kohn, D. (1994). Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo. Proc. Natl. Acad. Sci. USA 91, 2567 - 2571.
8. Danø, K., Andreasen, P.A., Grondahl-Hansen, J., Kristensen, P., Nielsen, L.S., and Skriver, L (1985). Plasminogen activators, tissue degradation, and cancer Adv. Cancer Res. 44, 139 - 266.
9. Ellis, V., Scully, M.F., and Kakkar, V.V. (1989). Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes. J. Biol. Chem. 264, 2185 - 2188.
10. Felgner, P.L, Gadek, T.R., Holm, M., Roman, R., Chan, H.W., Wenz, M., Northrop, J.P., Ringold, G.M., and Danielsen, M. (1987). Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA 84, 7413 - 7417.
11. Gouilleux, F., Sola, B., Couette, B., and Richard-Foy, H. (1991). Cooperation between structural elements in hormono-regulated transcription from the mouse mammary tumor virus promoter. Nucl. Acids Res. 19, 1563 - 1569.
12. Günzburg, W., and Groner, B. (1984). The chromosomal integration site determines the tissue specific methylation of mouse mammary tumor virus pro viral genes. EMBO J. 3, 1129 - 1135.
13. Günzburg, W., Heinemann, F., Wintersperger, S., Miethke, T., Wagner, H., Erfle, V., and Salmons, B. (1993). Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat. Nature 364, 154 - 158.
14. Günzler, W.A., Steffens, G.J., Ötting, F., Flohe, L., Heyneker, H., and Holmes, W. (1983). Structural determination of urokinase and its production by genetically transformed bacteria-cloning and gene expression of human gene in Escherichia coli. Hoppe Seyler Z. Physiol. Chem. 364, 335 - 343.
15. Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680 - 685.
16. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982). Molecular Cloning, A Laboratory Manual, 2nd ed., Vols. 1, 2 and 3. (Cold Spring Harbor. New York, USA: Cold Spring Harbor Laboratory).
17. Markwell, M. (1982). A new solid-state reagent to iodinate proteins. I. Conditions for the efficient labeling of antiserum. Anal. Biochem. 125, 427 - 432.
18. Mink, S., Ponta, H., and Cato, A. (1990). The long terminal repeat region of the mouse mammary tumor virus contains multiple regulatory elements. Nucl. Acids Res. 18, 2017 - 2024.
19. Mok, E., Golovkina, T., and Ross, S. (1992). A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but not lactation-dependent expression in transgenic mice. J. Virol. 66, 7529 - 7532.
20. Muller, W.J., Lee, F.S., Dickson, C., Peters, G., Pattengale, P., and Leder, P. (1990). The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J. 9, 907 - 913.
21. Muller, W., Sinn, E., Pattengale, P., Wallace, R., and Leder, P. (1988). Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54, 105 - 115.
22. Mummaneni, P., Bishop, P.L., and Turker, M.S. (1993). Acis-acting element accounts for a conserved methylation pattern upstream of the mouse adenine phosphoribosyltransferase gene. J. Biol. Chem. 268, 552 - 558.
23. Nielsen, L.S., Kellerman, G.M., Behrendt, N., Picone, R., Danø, K., and Blasi, F. (1988). A 55 000 - 60 000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification. J. Biol. Chem. 263, 2358 - 2363.
24. Palmiter, R.D., Chen, H.Y., and Brinster, R.L. (1982). Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell 29, 701 - 710.
25. Ploug, M., Kjalke, M., Rønne, E., Weidle, U., Høyer-Hansen, G., and Danø, K. (1993). Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins. J. Biol. Chem 268, 17539 - 17546.
26. Reick, W., Collick, A., Norris, M.L., Barton, S.C., and Surani, M.A. (1987). Genomic imprinting determines methylation of parental alleles in transgenic mice. Nature 328, 248 - 251.
27. Reick, W. (1989). Genomic imprinting and genetic disorders in man. TIGS 5, 331 - 336
28. Roldan, A.L., Cubellis, M.V., Masucci, M.T., Behrendt, N., Lund, L.R., Danø, K., Appella, E., and Blasi, F. (1990). Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J. 9, 467 - 474.
29. Rønne, E., Behrendt, N., Ploug, M., Nielsen, H.J., Wöllisch, E., Weidle, U., Danø, K., and Høyer-Hansen, G. (1994). Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay. J. Immunol. Meth. 167, 91 - 101.
30. Saiki, R.K., Gelfand, D.H., Stoffel, S., Scharf, S.J., Higuchi, R., Horn, G.T., Mullis, K.B., and Ehrlich, H.A. (1988). Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487 - 491.
31. Sapienza, C., Tran, T.H., Paquette, J., McGowan, R., and Peterson, A. (1987). A methylation mosaic model for mammalian genome imprinting. Nature 328, 251 - 254.
32. Schmitt, M., Wilhelm, O., Jänicke, F., Magdolen, V., Reuning, U., Ohi, H., Moniwa, H., Kobayashi, H., Weidle, U.H., and Graeff, H. (1995). Urokinase-type plasminogen activator (uPA) and its receptor (CD87): a new target in tumor invasion an metastasis. J. Obstet. Gynaecol. 21, 151 - 165.
33. Selker E.U., and Stevens J.N. (1987). Signal for DNA methylation associated with tandem duplication in Neurospora crassa. Mol. Cell. Biol. 7, 1032 - 1038.
34. Severne, Y., Wieland, S., Schaffner, W., and Rusconi, S. (1988). Metal binding "finger" structures in the glucocorticoid receptor defined by site-directed mutagenesis. EMBO J. 7, 2503 - 2508.
35. Solberg, H., Lober, D., Eriksen, J., Ploug, M., Rønne, E., Behrendt, N., Danø, K., and Høyer-Hansen, G. (1992). Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator. Eur. J. Biochem. 205, 451 - 458.
36. Southern, P.J., and Berg, P. (1982). Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV 40 early region promoter. J. Mol. Appl. Gen. 1, 327 - 341.
37. Swain, J.L., Stewart, T.A., and Leder, P. (1987). Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting. Cell 50, 719 - 730.
38. Szyf, M., Schimmer, B.P., and Seidman, J.G. (1989). Nucleotide-sequence-specific de novo methylation in a somatic murine cell line. Proc. Natl. Acad. Sci. USA 86, 6853 - 6857.
39. Weidle, U.H., Lenz, H., and Brem, G. (1991). Genes encoding a mouse monoclonal antibody are expressed in transgenic mice, rabbits and pigs. Gene 98, 185 - 191.
40. Weinberg, R.A. (1991). Tumor suppressor genes. Science 254, 1138 - 1146.
41. Yanagawa, S., Tanaka, H., and Ishimoto, A. (1991). Identification of a novel mammary cell line-specific enhancer element in the long terminal repeat of mouse mammary tumor virus, which interacts with its hormone-responsive element. J. Virol. 65, 526 - 531.