Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-α production: Effects of the stereoisomers of (3-hydroxycyclopentyl)adenines

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2615-2620

  Borcherding, David R ^a,b   Peet, Norton P ^a   Munson, H Randall ^a   Zhang, Hao ^a   Hoffman, Paul F ^a   Bowlin, Terry L ^a   Edwards III, Carl K ^a  

^a SANOFI   (France)

^b Discovery Chemistry   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 (3 HYDROXYCYCLOPENTYL)ADENINE; BACTERIUM LIPOPOLYSACCHARIDE; CARBOCYCLIC NUCLEOSIDE; CYCLOPENTANE DERIVATIVE; CYTOKINE; GALACTOSAMINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DIASTEREOISOMER; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTOXEMIA; FEMALE; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN;

ADENINE; ADENOSINE; ANIMALS; CYCLOPENTANES; GALACTOSAMINE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; STEREOISOMERISM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029903253     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950906t     Document Type: Article

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