The effects of central administration of the CCK-B receptor agonist pentagastrin on feeding and cortisol release in sheep

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 18, Issue 4, 1996, Pages 235-238

  Ebenezer, Ivor S ^a   Parrott, Robert F ^b  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Anxiety; CCK B receptors; Cortisol; Food intake; Intracerebroventricular; Panic; Pentagastrin; sheep

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; HYDROCORTISONE; PENTAGASTRIN;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; FEEDING BEHAVIOR; FOOD INTAKE; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; NONHUMAN; PANIC; SHEEP;

ANIMALS; ANXIETY DISORDERS; FEEDING BEHAVIOR; FEMALE; FOOD DEPRIVATION; HYDROCORTISONE; INJECTIONS, INTRAVENTRICULAR; MALE; PANIC DISORDER; PENTAGASTRIN; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; SHEEP;

EID: 0029903067     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Della-Fera, M.A., Baile, C.A. Cholecystokinin octapeptide: Continuous picomole injections into the cerebral ventricles of sheep suppress feeding. Science 1979, 206: 471-3.
2. Harro, J., Vasar, E., Bradwejn, J. CCK in animal and human research on anxiety. Trends Pharmacol Sci 1993, 14: 244-9.
3. Bradwejn, J., Koszychi, D., Couetoux du Tertre, A., Bourin, M., Palmour, R., Ervin, F. The cholecystokinin hypothesis of panic and anxiety disorders: A review. J Psychopharmacol 1992, 6: 345-52.
4. Singh, L., Fields, M.J., Hughes, J. et al. The behavioural properties of CI-988, a selective cholecystokinin-B receptor antagonist. Brit J Pharmacol 1991, 104: 239-345.
5. Rataud, J., Darche, F., Piot, F.O., Stutzmann, J.M., Bohme, G.A., Blanchard, J.C. Anxiolytic effect of CCK-antagonists on plus-maze behaviour in mice. Brain Res 1991 548: 315-7.
6. Bradwejn, J., Koszycki, D., Shriqui, D. Enhanced sensitivity to cholecystokinin tetrapeptide in panic disorder. Arch Gen Psychiat 1991, 48: 603-10.
7. Parrott, R.F. Peripheral and central effects of CCK receptor agonists on operant feeding in pigs. Physiol Behav 1993, 53: 367-72.
8. Rupniak, N.M., Schaffer, L., Siegal, P., Iverson, S.D. Failure of intravenous pentagastrin challenge to induce panic-like effects in rhesus monkeys. Neuropeptides 1993, 25: 115-9.
9. Ebenezer, I.S., Kendrick, K.M., Baldwin, B.A. Movable intracranial stimulating electrode system, electroencephalogram, and evoked potential recording in pigs and sheep. In: Methods in NeuroScience. Conn, P. (Ed.). Academic Press: New York 1991, 233-49.
10. Parrott, R.F., Ebenezer, I.S., Baldwin, B.A., Forsling, M.L. Central and peripheral doses of cholecystokinin that inhibit feeding in pigs also stimulate vasopressin and cortisol release. Exp Physiol 1991, 76: 525-31.
11. Itoh, S., Hirota, R., Katsuura, G., Odaguchi, K. Suppressive effect of pentagastrin on pituitary-adreno-cortical secretion. Endocrinol Jpn 1979, 26: 741-7.
12. 2 on feeding and cortisol release in pigs. Pharmacol Biochem Behav 1996, in press.
13. Della-Fera, M.A., Baile, C.A. Peptides with CCK-like activity administered intracranially elicit satiety in sheep. Physiol Behav 1981, 26: 979-83.