Glucagon inhibits hepatocyte nitric oxide synthesis

Archives of Surgery

Volumn 131, Issue 12, 1996, Pages 1266-1272

  Harbrecht, Brian G ^a,b   Wirant, Elizabeth M ^a,b   Kim, Yoimg Myeong ^a   Billiar, Timothy R ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; INTERLEUKIN 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; GENE EXPRESSION REGULATION; LIVER CELL; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

EID: 0029902521     PISSN: 00040010     EISSN: None     Source Type: Journal    
DOI: 10.1001/archsurg.1996.01430240020002     Document Type: Article

References (23)

1. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992;6:3051-3064.
2. Morris SM Jr, Billiar TR. New insights into the regulation of inducible nitric oxide synthesis. AmJPhysiol. 1994;266:E829-E839.
3. Harbrecht BG, Billiar TR, Stadier J, et al. Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia. Crit Care Med. 1992; 20:1568-1574.
4. Harbrecht EG, Wu B, Watkins SC, Marshall HP Jr, Peitzman AB, Billiar TR. Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury. Shock. 1995:4:332-337.
5. Geller DA, deVera ME, Russell DA, et al. A central role for IL-1β in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. J Immunol. 1995:155:4890-4898.
6. Harbrecht BG, DiSilvio M, Demetris AJ, Simmons RL, Billiar TR. Tumor necrosis factor-alpha regulates in vivo nitric oxide synthesis and induces hepatic injury during endotoxemia. Hepatology. 1994:20:1055-1060.
7. Molina y Vedia M, McDonald B, Reep B, et al. Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem. 1992:267:2492924932.
8. Kraus-Friedmann N. Hormonal regulation of hepatic gluconeogenesis. Physiol Rev. 1984:64:170-259.
9. Kelly E, Shah NS, Morgan NN, Watkins SC, Peitzman AB, Billiar TR. Physiologic and molecular characterization of the role of nitric oxide in hemorrhagic ' shock: evidence that type II nitric oxide synthase does not regulate vascular decompensation. Shock. In press.
10. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162: 156-159.
11. Puschel GP, Kirchner C, Schröder A, Jungermann K. Glycogenolytic and antiglycogenolytic prostaglandin E2 actions in rat hepatocytes are mediated via different signalling pathways. Eur J Biochem. 1993:218:1083-1089.
12. Geller DA, Nussler AK, DiSilvio M, et al. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc NatlAcad Sci USA. 1993:90:522-526.
13. Vodovotz Y, Bogdan C, Paik J, Xie Q, Nathan C. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β. J Exp Med. 1993:178:605-613.
14. Bogdan C, Vodovotz Y, Paik J, Xie Q, Nathan C. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J Leukoc Biol. 1994:55:227-233.
15. Nussler AK, DiSilvio M, Liu 2-2, et al. Further characterization and comparison of inducible nitric oxide synthase in mouse; rat, and human hepatocytes. Hepatology. 1995:21:1552-1560.
16. Harbrecht BG, Kirn Y-M, Wirant EA, Shapiro RA, Billiar TR. PGE2 and LTB, inhibit cytokine-stimulated nitric oxide production in isolated rat hepatocytes by decreasing iNOS mRNA. Prostaglandins. In press.
17. lyengar R, Swartz TL, Birnbaumer L. Coupling of glucagon receptor to adenylyl cyclase. J Biol Chem. 1979:254:1119-1123.
18. Werner-Felmayer G, Werner ER, Fuehs D, Hausen A, Reignegger G, Waehter H. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J Exp Med. 1990:2:1599-1607.
19. Harbrecht BG, DiSilvio M, Chough V, Kim Y-M, Simmons RL, Billiar TR. Glutathione regulates nitric oxide synthase in cultured hepatocytes. Ann Surg. In press.
20. Christophe J. Glucagon receptors: from genetic structure and expression to effector coupling and biological responses. Biochim BiophysActa. 1995;1241: 45-57.
21. Jordan ML, Rominski B, Jacquis-Gerstl A, Geller D, Huffman RA. Regulation of inducible nitric oxide production by intracellular calcium. Surgery. 1995; 118:138-146.
22. 2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability. J Cell Biol. 1995; 129:1651-1657.
23. Svoboda M, Tastenoy M, Vertongen P, Robberecht P. Relative quantitative analysis of glucagon receptor mRNA in rat tissues. Mol Cell Endocrinol. 1994;105: 131-137.