Expression of human decay accelerating factor (hDAF) in transgenic pigs regulates complement activation during ex vivo liver perfusion - Immunopathological findings

Transplant International

Volumn 9, Issue SUPPL. 1, 1996, Pages

  Pascher, A ^a   Poehlein, Ch ^a   Storck, M ^b   Abendroth, D ^b   Mueller Hoecker, J ^a   Koenig, W ^d   Young, V K ^c   White, D J G ^d   Hammer, C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c PAPWORTH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Complement; Decay accelerating factor; Ex vivo perfusion; Immunohistology; Transgenic pig

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; DECAY ACCELERATING FACTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; IMMUNOHISTOLOGY; IMMUNOPATHOLOGY; LIVER PERFUSION; LIVER PROTECTION; NONHUMAN; PRIORITY JOURNAL; SWINE; TRANSGENIC ANIMAL;

EID: 0029902308     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.1996.tb01657.x     Document Type: Article

References (11)

1. Baldwin WM III, Pruitt SK, Brauer RB, et al (1995) Complement in organ transplantation - contributions to inflammation, injury and rejection. Transplantation 59: 797-808
2. Burdick JF, Fair JH (1994) Xenoperfusion: the pig liver as a bridge. Xeno 2: 3-5
3. Carrington CA, Richards AC, Cozzi E, et al (1995) Expression of human DAF and MCP on pig endothelial cells protects from human complement. Transplant Proc 27: 321-323
4. Chari RS, Collins BH, Magee JC, et al (1994) Treatment of hepatic failure with ex vivo pig liver perfusion followed by liver transplantation. N Engl J Med 331: 234-237
5. Cozzi E, Langford GA, Wright L, et al (1995) Comparative analysis of human DAF expression in the tissues of transgenic pigs and man. Transplant Proc 27: 319-320
6. Makowka L, Cramer DV, Hoffman A, et al (1995) The use of a pig liver xenograft for temporary support of a patient with fulminant hepatic failure. Transplantation 59: 1654-1659
7. McKenzie IFC, Koulmanda M, Mandel T, et al (1995) Comparative studies of the major xenoantigen galα(1,3)gal in pigs and mice. Transplant Proc 27: 247-248
8. Neuhaus P, Blumhardt G (1993) Extracorporeal liver perfusion: applications of an improved model for experimental studies of the liver. Int J Artif Organs 16: 729-739
9. Rosengard AM, Cary NRB, Langford GA, et al (1995) Tissue expression of human complement inhibitor, decay accelerating factor, in transgenic pigs - a potential approach for preventing xenograft rejection. Transplantation 59: 1325-1333
10. Schön MR, Lemmens HP, Neuhaus P, et al (1994) Improved xenogeneic extracorporeal liver perfusion. Transplant Proc 26: 1293-1297
11. Yannoutsos N, Langford GA, Cozzi E et al (1995) Production of pigs transgenic for human regulators of complement activation. Transplant Proc 27: 324-325