Clinical validation of renin monoclonal antibody-based sandwich assays of renin and prorenin, and use of renin inhibitor to enhance prorenin immunoreactivity

Clinical Chemistry

Volumn 42, Issue 7, 1996, Pages 1051-1063

  Derkx, Frans H M ^a   De Bruin, René J A ^a   Van Gool, Jeanette M G ^a   Van Den Hoek, Marie José ^b   Beerendonk, Catharina C M ^c   Rosmalen, Frans ^b   Haima, Peter ^b   Schalekamp, Maarten A D H ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Nichols Institute Diagnostics   (Netherlands)

^c CATHARINA HOSPITAL   (Netherlands)

Author keywords

angiotensin; avidin biotin interaction; enzyme kinetic method compared; hyperaldosteronism; hypertension; immunoradiometric assay; infertility studies; reference values; Remikiren; renin inhibitor

Indexed keywords

ANGIOTENSIN; CHORIONIC GONADOTROPIN; ENALAPRIL; GONADOTROPIN; HUMAN MENOPAUSAL GONADOTROPIN; LEUPRORELIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY R 3 36 16; PRORENIN; REMIKIREN; RENIN; RENIN INHIBITOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ESSENTIAL HYPERTENSION; FEMALE; GONADOTROPIN RELEASE; HUMAN; IMMUNORADIOMETRIC ASSAY; IMMUNOREACTIVITY; INFERTILITY; MAJOR CLINICAL STUDY; MALE; PLASMA RENIN ACTIVITY; PRIMARY HYPERALDOSTERONISM; RENOVASCULAR HYPERTENSION;

EID: 0029902283     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/42.7.1051     Document Type: Article

References (39)

1. Sealey JE, Laragh JH. The renin-angiotensin-aldosterone system for normal regulation of blood pressure and sodium and potassium homeostasis. In: Laragh JH, Brenner BM, eds. Hypertension: pathophysiology, diagnosis, and management. New York: Raven Press, 1995:1763-96.
2. Lever AF, Lyall F, Morton JJ, Folkow B. Angiotensin II, vascular structure and blood pressure. Kidney Int 1992;37(Suppl):s51-5.
3. Dzau VJ. Tissue renin-angiotensin system in myocardial hypertrophy and failure. Arch Intern Med 1993;153:937-42.
4. Morris RS, Paulson RJ, Lindheim SR, Legro RS, Lobo RA, Sauer MV. Angiotensin-converting enzyme inhibition reverses luteal phase steroid production in oocyte donors. Fertil Steril 1995;63: 854-8.
5. Sealey JE. Plasma renin activity and plasma prorenin assays. Clin Chem 1991;37:1811-9.
6. Kahlid BA, Burke CW, Hurley DM, Funder JW, Stockigt JR. Steroid replacement in Addison's disease and in subjects adrenalectomized for Gushing disease: comparison of various glucocorticoids. J Clin Endocrinol Metab 1982;55:551-9.
7. Laragh JH. Renin profiling for diagnosis, risk assessment, and treatment of hypertension. Kidney Int 1993;44:1163-75.
8. Derkx FHM, Stuenkel C, Schalekamp MPA, Visser W, Huisveld IH, Schalekamp MADH. Immunoreactive renin, prorenin, and enzymatically active renin in plasma during pregnancy and in women taking oral contraceptives. J Clin Endocrinol Metab 1986;63:1008-15.
9. Itskovitz J, Sealey JE, Glorioso N, Rosenwaks Z. Plasma prorenin response to hCG in ovarian hyperstimulated women: correlation with the number of ovarian follicles and steroid hormone concentrations. Proc Natl Acad Sci USA 1987;84:7285-9.
10. Sealey JE, Goldstein M, Pitarresi T, Kudlak TT, Glorioso N, Flamengo SA, Laragh JH. Prorenin secretion from human testis: no evidence for secretion of active renin or angiotensinogen. J Clin Endocrinol Metab 1988;66:974-8.
11. Racz K, Pinet F, Gasc JM, Guyenne TT, Corvol P. Coexpression of renin, angiotensinogen, and their messenger ribonucieic acids in adrenal gland. J Clin Endocrinol Metab 1992;75:730-7.
12. Poisner AM, Dowing GJ, Poisner R. Prorenin secretion from villous placenta: regulation by cyclic AMP and angiotensin. Placenta 1994;15:487-99.
13. Derkx FHM, Tan-Tjiong HL, Wenting GJ, Boomsma F, Man in't Veld AJ, Schalekamp MADH. Asynchronous changes in prorenin and renin secretion after captopril in patients with renai artery stenosis. Hypertension 1983;5:244-56.
14. Corvol P, Pinet F, Plouin PF, Bruneval P, Ménard J. Renin-secreting tumors. Endocrinol Metab Clin North Am 1994;23:255-70.
15. Leckie BJ, Birnie G, Carachi R. Renin in Wilm's tumor: prorenin as an indicator. J Clin Endocrinol Metab 1994;79:1742-6.
16. Luetcher JA, Kraemer FB, Wilson DM, Schwartz HC, Bryer-Ash M. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N Engl J Med 1985;312:1412-7.
17. Franken AAM, Derkx FHM, Man in 't Veld AJ, Hop W, van Rens GH, Peperkamp E, Schalekamp MADH. High plasma prorenin in diabetes mellitus and its correlation with some complications. J Clin Endocrinol Metab 1990;71:1008-15.
18. Derkx FHM, Schalekamp MPA, Schalekamp MADH. Two-step prorenin-renin conversion. Isolation of an intermediary form of activated prorenin. J Biol Chem 1987;262:2472-7.
19. Pitarresi TM, Rubattu S, Heinrikson R, Sealey JE. Reversible cryoactivation of recombinant prorenin. J Biol Chem 1992;267: 11753-9.
20. Blundell T, Sibanda BL, Pearl L. Three-dimensional structure, specificity and catalytic mechanism of renin. Nature 1983;304: 273-5.
21. Derkx FHM, Deinum J, Lipovski M, Verhaar M, Fischli W, Schalekamp MADH. Nonproteolytic "activation" of prorenin by active site-directed renin inhibitors as demonstrated by renin-specific monoclonal antibody. J Biol Chem 1992;267:22837-42.
22. Fischli W, Clozel JP, Amrani KE, Wostl W, Neidhart W, Stadler H, Branca Q. Ro 42-5892 is a potent orally active renin inhibitor in primates. Hypertension 1991;18:22-31.
23. Heusser CH, Bews JPA, Alkan SS, Dietrich FM, Wood J, de Gasparo MM, Hofbauer KG. Monoclonal antibodies to human renin: properties and applications. Clin Exp Hypertens A 1987;9: 1259-75.
24. Zuo WM, Pratt RE, Heusser CH, Bews JPA, de Gasparo MM, Dzau VJ. Characterization of a monoclonal antibody specific for active renin. Hypertension 1992;19:249-54.
25. Parham A, Andrelewicz MJ, Brodsky FM, Holmes HJ, Ways JP. Monoclonal antibodies: purification, fragmentation and application to structural and functional studies of class I MHC antigens. J Immunol Methods 1982;53:133-73.
26. Odell WD, Griffin J, Zahradnik R. Two-monoclonal-antibody sandwich-type assay for thyrotropin, with use of an avidin-biotin separation technique. Clin Chem 1986;32:1873-8.
27. 131I-labelled human growth hormone of high specific radioactivity. Biochem J 1963;89:114-23.
28. Galen FX, Devaux C, Atlas SA, Gyenne T, Menard J, Corvol P, et al. New monoclonal antibodies directed against human renin. J Clin Invest 1984;74:723-35.
29. Simon D, Hartmann DJ, Badouaille G, Caillot G, Guynne TT, Corvol P, et al. Two-site direct immunoassay for active renin. Clin Chem 1992;38:1959-62.
30. Bangham R, Robertson I, Robertson JIS, Robinson CJ, Tree M. An international collaborative study of renin assay: establishment of the International Reference Preparation of human renin. Clin Sci Mol Med 1975;48:135s-59s.
31. Admiraal PJJ, Derkx FHM, Danser AHJ, Pieterman H, Schalekamp MADH. Metabolism and production of angiotensin I in different vascular beds in subjects with hypertension. Hypertension 1990; 15:44-55.
32. Skinner SL, Dunn JR, Mazzetti J, Campbell DJ, Fidge NH. Purification, properties and kinetics of sheep and human renin substrates. Aust J Exp Biol Med Sci 1975;53:77-88.
33. Solberg HE. Statistical treatment of collected reference values. Determination of reference limits. J Clin Chem Clin Biochem 1987;25:645-56.
34. Ekins R. Immunoassay design and optimization. In: Price CP, Newman DJ, eds. Principles and practice of immunoassay. New York: Stockton Press,1991:154-89.
35. Morganti A, Pelizzola D, Mantero F, Gazzano G, Opocher G, Piffanelli A. Immunoreactive versus enzymatic renin assay: results of the Italian multicenter comparative study. J Hypertens 1995;13: 19-26.
36. Meiracker AH, Admiraal PJJ, Derkx FHM, Kleinboesem C, Man in't Veld AJ, van Brummelen P, et al. Comparison of blood pressure and angiotensin responses to the renin inhibitor Ro 42-5892 and the angiotensin converting enzyme inhibitor enalapril in essential hypertension. J Hypertens 1993;11:831-8.
37. Sealey JE, Trenkwalder P, Gahnem F, Catanzaro D, Laragh JH. Plasma renin methodology: inadequate sensitivity and accuracy of direct renin assay for clinical applications compared with the traditional enzymatic plasma renin activity assay. J Hypertens 1995;13:27-30.
38. Rasmussen S, Damkjaer Nielsen M, Giese J. Captopril combined with thiazide lowers renin substrate concentration: implications for methodology in renin assays. Clin Sci 1981;60:591-3.
39. Arnal JF, Cudek P, Plouin PF, Guyenne TT, Michel JB, Corvol P. Low angiotensinogen levels are related to the severity and liver dysfunction of congestive heart failure: implications for renin measurements. Am J Med 1991;90:17-22.