New aspects of migraine pathophysiology: Lessons learned from positron emisson tomography

Current Opinion in Neurology

Volumn 9, Issue 3, 1996, Pages 199-201

  Diener, H C ^a   May, A ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION CORTEX; BRAIN BLOOD FLOW; BRAIN STEM; HUMAN; MIGRAINE; POSITRON EMISSION TOMOGRAPHY; SHORT SURVEY;

EID: 0029902041     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-199606000-00007     Document Type: Short Survey

References (12)

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2. Olesen J, Larsen B, Lauritzen M: Focal hyperemla followed by spreading oligemis and Impaired activation of rCBF in classic migraine. Ann Neurol 1981,9:344-352.
3. Olesen J, Friberg L: Xenon-133 SPECT studies in migraine without aura. In Migraine and other headaches: the vascular mechanisms. Edited by Olesen J. London: Raven Press; 1991:237-243.
4. Lauritzen M: Pathophysiology of the migraine aura - the spreading depression theory. Brain 1994, 117:199-210.
5. Woods RP, Iacoboni M, Mazziotta JC: Bilateral spreading cerebral hypo•• perfusion during spontaneous migraine headache. New Engl J Med 1994, 331:1689-1692. This case report in a patient with a spontaneous migraine attack while being investigated for another reason in a PET scanner provided cerebral blood flow data indicating that spreading depression might exist during human migraine.
6. Olesen J, Tfelt-Hansen P, Henriksen L, Larsen B: The common migraine attack may not be initiated by cerebral ischaemia. Lancet 1981, ii:438-440.
7. Friberg L, Olesen J, Iversen H, Nicolic I, Sperling B, Lassen NA, Olsen TS, Tfelt-Hansen P: Interictal 'patchy' regional cerebral blood flow pattens in migraine patients. A single photon emission computerized tomographic study. Eur J Neurol 1994, 1:35-43.
8. Goadsby PJ, Edvinsson L: The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 1993, 33:48-56.
9. Weiller C, May A, Limmroth V, Jüptner M, Kaube H, van Schayck R, •• Coenen HH, Diener HC: Brain stem activation in human migraine attacks. Nature Med 1995, 1:658-660. This PET study in nine patients with sponateous migraine attacks found an area of increased cerebral blood flow in the brain stem which persisted after the headache was treated with sumatriptan, indicating that this might reflect a 'migraine centre' in the brainstem.
10. Ferrari MD, Haan J, Blokland JAK, Arndt JW, Minnee P, Zwinderman AH, • Pauwels EKJ, Saxena PR: Cerebral blood flow during migraine attacks without aura and effect of sumatrlptan. Arch Neurol 1995, 52:135-139. This study found no changes of cerebral blood flow during migraine attacks without aura compared with the headache-free interval. Sumatripan had no effect on cerebral blood flow despite being a vasoconstrictor.
11. Headache Classification Committee of the International Headache Society: Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988, 8(suppl 7):19-28.
12. Ferrari MD, James MH, Bates D, Pilgrim AJ, Ashford E, Anderson BA, • Nappi G: Oral sumatriptan: effect of a second dose, and incidence and treatment of headache recurrences. Cephalalgia 1994, 14:330-338. This study provides important data on the recurrence rate of headache after relief from headache treated with sumatriptan. The results suggest that migraine drugs might only suppress the pain but are not able to stop the basic pathophysiological process.