Treatment with antiepileptic drugs: Possible neuroprotective effects

Neurology

Volumn 47, Issue 1 SUPPL., 1996, Pages

  Pitkänen, Asla ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; NEURON SPECIFIC ENOLASE; VIGABATRIN;

AMNESIA; ARTICLE; BRAIN SIZE; CLINICAL TRIAL; DRUG EFFECT; EPILEPTIC STATE; HIPPOCAMPUS; HUMAN; MICROGLIA; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFORANT NERVE TRACT; PRIORITY JOURNAL; SEIZURE THRESHOLD; TEMPORAL LOBE EPILEPSY;

EID: 0029901950     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.47.1_suppl_1.12s     Document Type: Article

References (19)

1. 2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease. Neurology 1996;46:1724-1730.
2. Babb TL, Pretorius JK. Pathological substrates of epilepsy. In: Wylie E, ed. The treatment of epilepsy: principles and practice. Philadelphia: Lea & Febiger, 1993:55-70.
3. Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 1986;6:2950-2967.
4. Moser E, Moser M-B, Andersen P. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J Neurosci 1993;13:3916-3925.
5. Zola-Morgan S, Squire LR, Rempel NL, Glower RP, Amaral DG. Enduring memory impairment in monkeys after ischemic damage to the hippocampus. J Neurosci 1992;12:2582-2596.
6. Cavazos JE, Das I, Sutula TP. Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures. J Neurosci 1994;14:3106-3121.
7. Mouritzen Dam A. Hippocampal neuron loss in epilepsy and after experimental seizures. Acta Neurol Scand 1982;66:601-642.
8. Mathern GW, Babb TL, Vickrey BG, Melendez M, Pretorius JK. The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy. Brain 1995;118:105-118.
9. DeGiorgio CM, Tomiyasu U, Gott PS, Treiman DM. Hippocampal pyramidal cell loss in human status epilepticus. Epilepsia 1992;33:23-27.
10. Saukkonen A, Kälviäinen R, Partanen K, Vainio P, Riekkinen P, Pitkänen A. Do seizures cause neuronal damage? An MRI study comparing the volumes of the hippocampus, amygdala, and parahippocampal gyrus in newly diagnosed and chronic epilepsy. Neuroreport 1994;6:219-223.
11. 2 relaxometry: correlation to verbal memory performance in newly diagnosed epilepsy patients with left-sided temporal lobe focus. Neurology (in press).
12. Nohria V, Lee N, Tien RD, et al. Magnetic resonance imaging evidence of hippocampal sclerosis in progression: a case report. Epilepsia 1994;35:1332-1336.
13. Jackson GD, Fitt GJ, Mitchell LA, Chambers BR, Berkovic SF. Hippocampal sclerosis developing in adults: progression of hippocampal MR findings [abstract]. Epilepsia 1995;36(suppl 3):S249.
14. Pitkänen A, Tuunanen J, Halonen T. Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus-induced neuronal damage in the hippocampus and amygdala. Epilepsy Res (in press).
15. Ylinen A, Miettinen R, Pitkänen A, Gulyas AI, Freund TF, Riekkinen PJ. Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy. Proc Natl Acad Sci USA 1991;88:7650-7653.
16. Halonen T, Nissinen J, Pitkänen A. Tiagabine prevents seizures, neuronal damage, and memory impairment in experimental status epilepticus. Eur J Pharmacol 1996;299:69-81.
17. Rabinowicz AL, Correale JD, Bracht KA, Smith TD, DeGiorgio CM. Neuron-specific enolase is increased after nonconvulsive status epilepticus. Epilepsia 1995;36:475-479.
18. DeGiorgio CM, Correale JD, Gott PS, et al. Serum neuron-specific enolase in human status epilepticus. Neurology 1995; 45:1134-1137.
19. Beach TG, Woodhurst WB, MacDonald DB, Jones MW. Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci Lett 1995;191:27-30.