Value of ICA512 antibodies for prediction and diagnosis of type 1 diabetes

Experimental and Clinical Endocrinology and Diabetes

Volumn 104, Issue 3, 1996, Pages 228-234

  Mayrhofer, M ^a   Rabin, D U ^b   Messenger, L ^b   Standl, E ^a   Ziegler, A G ^a  

^a Klinikum Schwabing   (Germany)

^b BAYER CORPORATION   (United States)

Author keywords

Diagnosis; ICA512 antibodies; Prediction; Type 1 diabetes; Tyrosine phosphatase IA 2

Indexed keywords

CD45 ANTIGEN; MEMBRANE PROTEIN; PANCREAS ISLET CELL ANTIBODY; PHOSPHATASE;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; ONSET AGE; PANCREAS ISLET CELL; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; SCHOOL CHILD; SCREENING TEST;

EID: 0029901233     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211447     Document Type: Article

References (20)

1. Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte MT, Bottazzo GF, Gale EAM: Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody positive relatives. Diabetes 43: 1304-1310, 1994.
2. Bonifacio E, Bingley PJ, Shattock M, Dean BM, Dünger D, Gale EAM, Botazzo GF: Quantification of isletcell antibodies and prediction of insulin-dependent diabetes. Lancet 147-49, 1990.
3. Bonifacio E, Genovese S, Braghi S, Bazzigaluppi E, Lampasona V, Bingley PJ, Rogge L, Pastore MR, Bognetti E, Bottazzo GF, Gale EAM, Bosi E: Islet autoantibody markers in IDDM: Risk assessment strategies yielding high sensitivity. Diabetologia 38: 816-822, 1995
4. Bonifacio E et al.: Identification of the IDDM-related 37k antigen as protein tyrosine phosphatase (IA-2/ICA512). Diabetologia 38 (suppl), 1995.
5. Christie MR, Brown TJ, Cassidy D: Binding of antibodies in sera from type I (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues: Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia 35: 380-84, 1992
6. Eisenbarth GS, Ziegler AG: Type 1 diabetes mellitus, In Molecular Endocrinology: Basic concepts and clinical correlations (ed Bruce D Weintraub), Raven Press, Ltd., New York 269-282, 1995.
7. Gianani R, Rabin D, Verge CF, Liping Y, Babu SR, Pietropaolo M, Eisenbarth GS: ICA512 autoantibody radioassay. Diabetes 44: 1340-1344, 1995.
8. Lan MS, Lu J, Goto Y, Notkins AL: Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13(5): 505-515, 1994.
9. Myers MA, Rabin DU, Rowley MJ: Pamcreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes 44: 1290-1295, 1995.
10. Payton MA, Hawkes CJ, Christie MR: Relationship of 37,000- and 40,000-Mr tryptic fragments of islet cell antigens in insulin-dependent diabetes to the protein tyrosine phosphatase IA-2 (ICA512). J Clin Invest 96, 1506-1511, 1995.
11. Petersen JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, Hoier-Madsen M, Boel E, Michelsen BK, Dyrberg T: Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43: 459-467, 1994.
12. Rabin DU, Pleasic SM, Palmer-Crocker R, Shapiro JA: Cloning and expression of IDDM-specific human autoantigens. Diabetes 41: 183-186, 1992
13. Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rea PMM: Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunology 152: 3183-3187, 1994.
14. Roll U, Christie MR, Füchtenbusch M, Ziegler AG: Antibodies to GAD are not the first that appear in life in offspring of diabetic mothers or fathers, but are of value for the prediction of type 1 diabetes. Diabetes 44: 77 A (suppl), 1995.
15. Roll U, Christie MR, Standl E, Ziegler AG: Association of anti-GAD-antibodies with islet cell antibodies and insulin autoantibodies in first degree relatives of type 1 diabetic patients. Diabetes 1994: 154-160, 1994.
16. Vardi R Ziegler AG, Mathews JH, Dib SA, Keller RJ, Ricker AT, Wolfsdorf JI, Herskowitz RD, Rabizadeh A, Eisenbarth GS, Soeldner JS: Concentrations of insulin autoantibodies at onset of Type 1 diabetes: Inverse log-linear correlation with age. Diabetes Care 11: 736-739, 1988.
17. Ziegler AG, Bachmann W, Rabl W: Prophylactic insulin treatment in relatives at high risk for type 1 diabetes. Diabetes/metabolism reviews 9: 289-293, 1993.
18. Ziegler AG, Hillebrand B, Rabl W, Mayrhofer M, Mollenhauer U, Vordemann J, Lenz A, Standl E: On the appearance of islet associated autoimmunity in offspring of diabetic mothers: A prospective study from birth. Diabetologia 36: 402-408, 1993.
19. Ziegler AG, Standl E, Albert E, Mehnert H: HLA-associated insulin autoantibody (IAA) formation in newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetes 40: 1146-1149, 1991.
20. Ziegler AG, Ziegler R, Vardi P, Jackson RA, Soeldner JS, Eisenbarth GS: Life table analysis of progression to diabetes of anti-insulin autoantibody positive relatives of Type 1 diabetics. Diabetes 38: 1320-1325, 1989.