Localized cerebellar reductions in benzodiazepine receptor density in human partial epilepsy

Archives of Neurology

Volumn 53, Issue 7, 1996, Pages 656-662

  Savic, Ivanka ^a   Thorell, J O ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CARBON 11; FLUMAZENIL; FLUORODEOXYGLUCOSE F 18; PHENYTOIN;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; CEREBELLUM DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FOCAL EPILEPSY; FRONTAL LOBE; GLUCOSE METABOLISM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PURKINJE CELL; RECEPTOR DENSITY; SEIZURE; TEMPORAL LOBE;

EID: 0029900792     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.1996.00550070094016     Document Type: Article

References (47)

1. Liebers M. Uber Kleinhirn atrophien bei Epilepsie nach epileptischen Krampfanfallen. Z Neurol Psychiatry. 1928;113:739-756.
2. Hoffman W. Cerebellar lesions after peripheral dilantin administration. Neurology. 1958;8:210-219.
3. Julien RM, Halpern LM, Diphenylphedantoin: evidence for a central action. Life Sci. 1971;10:575-582.
4. Spielmeyer W. The anatomic substratum of the convulsive state. Arch Neurol Psychiatry. 1930;23:869-875.
5. Margerison JH, Corsellis JAN. Epilepsy and the temporal lobes: a clinical, electroencephalographic, and neuropathologic study of the brain in epilepsy, with particular reference to the temporal lobes. Brain. 1966;89:499-530.
6. Dam M. Number of Purkinje cells in patients with grand mal epilepsy treated with diphenylhydantoin. Epilepsia. 1970;11:313-320.
7. Ito M, ed. The Cerebellum and Neural Control. New York, NY: Raven Press; 1984:14-15.
8. Heith RG, Harper J. Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: evoked potential and histological studies in monkeys and cats. Exp Neurol. 1974;4:268-287.
9. Dietrichs E. Divergent axon collaterals to cerebellum and amygdala from neurons in the parabrachial nucleus, the nucleus locus ceruleus and some adjacent nuclei. Anat Embryol (Berl). 1985;172:375-382.
10. Supple WF Jr, Kapp BS. Anatomical and physiological relationships between the anterior cerebellar vermis and the pontine parabrachial nucleus in the rabbit. Brain Res Bull. 1994;33:561-574.
11. Takeushi Y, Mc Lean J, Hopkins D. Reciprocal connections between amygdala and parabrachial nuclei: ultrastructural demonstration by degeneration and axonal transport of horseradish peroxidase in cat. Brain Res. 1982;239:583-588.
12. Nevander G, Ingvar M, Auer R, et al. Status epilepticus in well-oxygenated rats causes neuronal necrosis. Ann Neurol. 1985;18:281-290.
13. Krnjevic K. GABA and other transmitters in the cerebellum. In: Palay SL, Chan-Palay V, eds. The Cerebellum: New Vistas. New York, NY: Springer-Verlag NY Inc; 1982:533-551.
14. Savic I, Roland P, Persson A, Pauli S, Sedvall G, Widen. In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. Lancet. 1988;2:864-866.
15. Savic I, Widén L, Thorell JO, Blomqvist G, Ericsson K, Roland PE. Cortical benzodiazepine receptor binding in patients with generalised and partial epilepsy. Epilepsia. 1990;31:724-730.
16. Savic I, Widén L, Stone-Elander S. Feasibility of reversing benzodiazepine tolerance with flumazenil. Lancet. 1991;337:133-137.
17. Savic I, Ingvar M, Stone-Elander S. Comparison of [11C]flumazenil and [18F]FDG as PET markers of epileptic foci. J Neurol Neurosurg Psychiatry. 1993;56:615-621.
18. Savic I, Pauli S, Thorell JO, Blomqvist G. In vivo demonstration of altered benzodiazepine receptor density in patients with primary generalised epilepsy. J Neurol Neurosurg Psychiatry. 1994;57:797-804.
19. Savic I, Svanborg E, Thorell JO. Cortical benzodiazepine receptor density is related to frequency of epileptic seizures. Epilepsia. In press.
20. Blomquist G, Pauli S, Farde L, et al. Maps of receptor binding parameters in the human brain - a kinetic analysis of PET measurements. Eur J Nucl Med. 1990;16:257-265.
21. Frey K, Holthoff V, Koeppe R, et al. Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. Ann Neurol. 1991;30:663-672.
22. Price JC, Mayberg HS, Dannals RF, et al. Measurement of benzodiazepine receptor number and affinity in humans using tracer kinetic modelling, positron emission tomography, and 11-C flumazenil. J Cereb Blood Flow Metab. 1993; 13:656-667.
23. d values with positron emission tomography. Eur J Pharmacol. 1992;213:107-115.
24. Savic I, Thorell JO, Roland PE. [11C]Flumazenil positron emission tomography visualised frontal epileptogenic regions. Epilepsia. In press.
25. Henry TR, Frey KA, Sackellares JC, et al. In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy. Neurology. 1993; 43:693-696.
26. Lassen NA, Bartenstein PA, Lammertsma AA, et al. Benzodiazepine receptor quantification in vivo in humans using [11C]flumazenil and PET: application of the steady-state principle. J Cereb Blood Flow Metab. 1995;15:152-165.
27. Delforge J, Pappata S, Mullet P, et al. Quantification of benzodiazepine receptor in human brain using PET, [11C]flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab. 1995;15:284-300.
28. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30:389-399.
29. Schmutz M, Bernasconi R, Baltzer V. Benzodiazepine antagonists, GABA and the mode of action of the antiepileptic drugs. In: Baldy-Moulnier DH, Meldrum BS, eds. Current Problems in Epilepsy. London, England: John Libbey Eurotext; 1983:378-384.
30. Litton J, Bergström M, Eriksson L, et al. Performance study of the PC-384-7B positron camera system for emission tomography of the brain. J Comput Assist Tomogr. 1984;8:74-87.
31. Litton JE, Holte S, Eriksson L. Evaluation of the Karolinska new positron camera system: the Scanditronix PC2048-15B. IEEE Trans Nucl Sci. 1990; 37:743-748.
32. Bergström M, Boethius J, Eriksson L, et al. Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr. 1981;5:136-141.
33. Ericsson L. Holte S, Bohm C, et al. Automated blood sampling system for positron emission tomography. IEEE Trans Nucl Sci. 1988;35:703-707.
34. A receptor subunits. Trends Pharmacol Sci. 1991;12:49-51.
35. Halldin C, Stone-Elander S, Thorell JO, et al. 11C-labelling of Ro 15-1788 in 2 different positions, and also 11C-labelling of its main metabolite Ro 15-3890, for PET studies of benzodiazepine receptors. Appl Radiat Isot. 1988;39:993-997.
36. Möhler H, Okada T. The benzodiazepine receptor in human brain. Sleep Res. 1979;1:3-12.
37. Engel J Jr, Brown W, Kuhl D, et al. Pathological findings underlying focal temporal hypometabolism in partial epilepsy. Ann Neurol. 1982;12:518-528.
38. Greitz T, Bohm C, Holte S, Eriksson L. A computerized brain atlas: construction, anatomical content and some applications. J Comput Assist Tomogr. 1991; 15:26-38.
39. Seitz R, Bohm C, Greitz T, et al. Accuracy and precision of the computerized brain atlas programme for localization and quantification in positron emission tomography. J Cereb Blood Flow Metab. 1990;10:443-457.
40. Snider RS, Maiti A. Cerebellar contributions to the Papez circuit. J Neurosci Res. 1976;2:133-146.
41. Thach WT, Montgomery EB. Motor system. In: Pearlman A, Collins R, eds. Neurological Pathophysiology. New York, NY: Oxford University Press Inc; 1984: 151-178.
42. Theodore WH, Fishbein D, Deitz M, Baldwin P. Complex partial seizures: cerebellar metabolism. Epilepsia. 1987;28:319-323.
43. Savic I, Altshuler L, Passaro E, Baxter L, Engel J Jr. Localized cerebellar hypometabolism in patients with complex partial seizures. Presented at the Annual Meeting of the American Electroencephalography Society; September 9, 1995; Baltimore, Md.
44. Chauvel P, Trottier S, Vignal JP, Bancaus J. Somatomoto seizures of frontal lobe origin. In: Chauvel P, Delgado Escueta AV, Halgren E, Bancaud J, eds. Advances in Neurology: Frontal Lobe Seizures and Epilepsies. New York, NY: Raven Press; 1992;57:185-232.
45. Bergman AJ, Berman D, Prescott JW. The effect of cerebellar lesions on emotional behavior in the rhesus monkey. In: Cooper IS, Riklan M, Snider RS, eds. The Cerebellum, Epilepsy, and Behaviour. New York, NY: Plenum Press; 1974: 277-285.
46. Fiez JA, Petersen SE, Cheney MK, Raiche ME. Impaired nonmotor learning and error detection associated with cerebellar damage: a single case study. Brain. 1992;115:155-178.
47. Chujo T, Yamada Y, Yamamoto C. Sensitivity of Purkinje cell dendrites to glutamic acid. Exp Brain Res. 1975;23:293-300.