Drug encapsulation and aerodynamic behavior of a lipid microtubule aerosol

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 3, Issue 1, 1996, Pages 9-15

  Johnson, D L ^a   Polikandritou Lambros, M ^a   Martonen, T B ^b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Fibrous aerosol; Lipid microtubule; Sodium cromoglycate; Spiral centrifuge; Therapeutic aerosol

Indexed keywords

1,2 BIS(10,12 TRICOSADIYNOYL) GLYCERO 3 PHOSPHOCHOLINE; ALCOHOL; CROMOGLYCATE DISODIUM; DRUG CARRIER; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENCAPSULATION; LIPID BILAYER; MICROTUBULE; PARTICLE SIZE; PHARMACEUTICS; PRIORITY JOURNAL; SUSPENSION; VISCOSITY;

EID: 0029900476     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549609031376     Document Type: Article

References (31)

1. Thompson, D. C. (1992) Pharmacology of therapeutic aerosols. In: Pharmaceuticals Inhalation Aerosol Technology, A. J. Hickey, Ed. Dekker, New York, pp. 29-59.
2. Byron, P. R. (1987) Pulmonary targeting with aerosols. Pharm. Technol. 11:43-56.
3. Gonda, I. (1992) Targeting by deposition. In: Pharmaceutical Inhalation Aerosol Technology, A. J. Hickey, Ed. Dekker, New York, pp. 61-82.
4. Crooks, P. A. (1992) Drug targeting to the lung: chemical and biochemical considerations. In: Pharmaceutical Inhalation Aerosol Technology, A. J. Hickey, Ed. Dekker, New York, pp. 83-127.
5. Martonen, T. B. (1993) Mathematical model for the selective deposition of inhaled pharmaceuticals. J. Pharm. Sci. 82(12):1191-1199.
6. Martonen, T. B., and Katz, I. (1993) Effects of aerosol polydispersity on deposition patterns within human lungs. J. Aerosol Med. 6:251-274.
7. Martonen, T. B., and Katz, I. (1993) Deposition patterns of aerosolized drugs within human lungs: effects of ventilatory parameters. Pharm. Res. 10:871-878.
8. Martonen, T. B., and Katz, I. (1994) Inter-relaled effects of morphology and ventilation on drug deposition patterns. J. Pharm. Sci. 4:11-18.
9. Martonen, T. B., Katz, I. M., and Cress, W. (1995) Aerosol drug deposition as a function of airway disease: cystic fibrosis. Pharm. Res. 12:96-102.
10. Gonda, I., and Khalik, A. F. A. (1988) Aerodynamic properties of different crystal forms of hexamethylmelamine. Ann. Occup. Hyg. 32:379-390.
11. Chan, H. K., and Gonda, I. (1989) Respirable form of crystals of cromoglycic acid. J. Pharm. Sci. 78(2):176-180.
12. Chan, H. K., and Gonda, I. (1989) Aerodynamic properties of elongated particles of cromoglycic acid. J. Aerosol Sci. 20(2):157-168.
13. Johnson, D. L., and Martonen, T. B. (1994) Behavior of inhaled fibers: potential applications to medicinal aerosols. Part. Sci. Technol. 12:161-173.
14. Stober, W., and Flachsbart, H. (1971) High resolulion aerodynamic size spectrometry of quasi-monodisperse latex spheres with a spiral centrifuge. Aerosol Sci. 2:103-116.
15. Harris, R. L., Jr., and Fraser, D. A. (1976) A model for deposition of fibers in the human respiratory system. Am. Ind. Hyg. Assoc. J. 37:73-89.
16. Johnson, D. L., and Martonen, T. B. (1994) Predicted and observed behavior of platelet aerosols. Part. Sci. Technol. 12:149-159.
17. Sussman, R. G., Cohen, B. S., and Lippman, M. (1991) Asbestos fiber deposition in a human tracheobronchial cast, I: experimental. Inhal. Toxicol. 3:145-160.
18. Brody, A. R., Hill, L. H., Adkins, B., and O'Connor, R. W. (1981) Chrysolite asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages. Am. Rev. Respir. Dis. 123:670-679.
19. Yager, P., and Schoen, P. E. (1984) Formation of tubules by a polymerizable surfactant. Mol. Cryst. Liq. Cryst. 106:371-381.
20. Schoen, P.E., Yager, P., and Priest, R.G. (1985). Spectroscopic Studies of a Diacetylenic Surfactant. NATO Advanced Study Institute Series on Polydiacetylenes, Stratford-Upon-Avon, U.K.
21. Georger, J. H., Singh, A., Price, R. R., Schnur, J. M., Yager, P., and Schoen, P. E. (1987) Helical and tubular microstructure formed by polymerizable phosphatidylcholines. J. Am. Chem. Soc. 109:6169-6175.
22. Rudolph, A. S., Singh, A., Price, R. R., Goins, B., and Gaber, B. P. (1990) Stabilization of lipid microstructures: fundamentals and applications. In: Targeting of Drugs, 2: Optimization Strategies, G. Gregoriadis, A. C. Allison, and G. Poste, Eds. Plenum, New York, pp. 103-115.
23. Stöber, W., and Flachsbart, H. (1969) Size-separating precipitation of aerosols in a spinning spiral duct. Environ. Sci. Technol. 3(12):1280-1296.
24. Johnson, D. L., and Martonen, T. B. (1989) Aerosol characterization with centrifugal aerosol spectrometers: theory and experiment. Am. Ind. Hyg. Assoc. J. 50(8):408-412.
25. Taylor, K. M. G., Taylor, G., Kellaway, I. W., and Stevens, J. (1988). The effects of nebulization on liposomal drug entrapment. J. Pharm. and Pharmacol. 40:137.
26. Taylor, K. M. G., Taylor, G., Kellaway, I. W., and Stevens, J. (1990). The stability of liposomes to nebulization. Int. J. Pharmaceutics 58:57-61.
27. Niven, R. W., and Schreier, H. (1990) Nebulization of liposomes, 1: effects of lipid composition. Pharm. Res. 7(11):1127.
28. Niven, R. W., Speer, M., and Schreier, H. (1991) Nebulization of liposomes, 2: the effects of size and modeling of solute release profiles. Pharm. Res. 8(2):217-221.
29. Niven, R. W., Carvajal, T. M., and Schreier, H. (1992) Nebulization of liposomes, 3: the effects of operating conditions and local environment. Pharm. Res. 9(4):515-520.
30. Yager, P., Schoen, P. E., Davies, C., Price, R. R., and Singh, A. (1985) Structure of lipid tubules formed from polymerizable lecithin. Biophys. J. 48:899-906.
31. Johnson, D. L., and Polikandritou-Lambros, M. (1995) Optimization of Therapeutic Liposomal Aerosols, Project No. HR3-089, Final Report to the Oklahoma Center for the Advancement of Science and Technology (OCAST), Oklahoma City, Oklahoma.