A corticoid synthesis from 9α-hydroxyandrost-4-ene-3,17-dione via a steroidal allene

Tetrahedron Letters

Volumn 37, Issue 20, 1996, Pages 3417-3420

  Andrews, David R ^a   Giusto, Robert A ^a   Sudhakar, Anantha R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CORTICOSTEROID; PREGNANE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0029900305     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00583-7     Document Type: Article

References (15)

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11. In a control experiment with the 9,17-diol corresponding to 3, the C-9 alcohol was inert to these acylating conditions.
12. The importance of the C-16 methyl substituent in influencing the epoxidation reaction was indicated by the observation that the C-17 allene derived from Ethisterone (C-16 des methyl) produced a mixture of isomers at C-17.
13. VanRheenen, V.; Shephard, K.P. J. Org. Chem. 1979, 44, 1582.
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