Mineral density gain in vertebrae of osteoporotic women on oral pamidronate reverts a year after treatment discontinuance

Calcified Tissue International

Volumn 59, Issue 1, 1996, Pages 70-72

  Zanchetta, J R ^a   Plotkin, H ^a   Roldan E J A ^a  

^a Instituto de Investigaciones Metabolicas   (Argentina)

Author keywords

absorptiometry; bisphosphonates; femoral neck; lumbar spine; oral pamidronate; Osteoporosis

Indexed keywords

PAMIDRONIC ACID;

ADULT; ARTICLE; BONE DENSITY; BONE METABOLISM; BONE MINERAL; BONE MINERALIZATION; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; HUMAN; LONG TERM CARE; LUMBAR SPINE; LUMBAR VERTEBRA; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; OSTEOLYSIS; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; BONE DENSITY; DIPHOSPHONATES; FEMALE; FEMUR NECK; HUMANS; LUMBAR VERTEBRAE; OSTEOPOROSIS, POSTMENOPAUSAL;

EID: 0029899701     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900088     Document Type: Article

References (16)

1. Boonekamp PM, van der Wee-Pals LJA, van Wijk-van Lennep MML, Thesing CW, Bijvoet OLM (1986) Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner 1:27-39
2. Harinck HIJ, Bijvoet OLM, Blanksma HJ, Dahlinghaus-Nienhuys PJ (1987) Efficacious management with APD in Paget's disease of bone. Clin Orthop 217:79-98
3. Fleisch H (1981) Diphosphonates: History and mechanisms of action. Metab Bone Dis & Res 4 and 5:279-82
4. Zanchetta JR, del Valle EE, Bogado CE, Spivacow FR, Perez Lloret A (1990) Improved bone mineralization content in patients with osteoporosis treated with the bisphosphonate APD. In: Christiansen C, Johansen JS (eds) Proc Third Int Symp Osteoporosis, Osteopress, Copenhagen, pp 1461-3
5. Reid IR, Wattie DJ, Evans MC, Gamble GD, Stapleton JP, Cornish J (1994) Continuous therapy with pamidronate, a potent bisphosphonate, in postmenopausal osteoporosis. J Clin Endocrinol Metab 79:1595-9
6. Papapoulos SE, Lowik CWGM, Bijvoet OLM, Valkema R, Landman JO, Papapoulos V, Pauwels EKJ, Vermeij P (1992) The use of bisphosphonates in the treatment of osteoporosis. Bone 13:41-9
7. Wingen F, Schmähl D (1987) Pharmacokinetics of the osteotropic diphosphonate 3-amino-1-hydroxypropane-1,1-diphosphonic acid in mammals. Arzneim Forsch Drug Res 37:1037-42
8. Mautalen CA, González D, Ghiringhelli G (1985) Efficacy of the bisphosphonate APD in the control of Paget's bone disease. Bone 6:429-32
9. Valkema R, Vismans FLFE, Papapoulos SE, Pauwels EKJ, Bijvoet OLM (1989) Maintained improvement in calcium balance and bone mineral content in patients with osteoporosis treated with the bisphosphonate APD. Bone Miner 5:183-92
10. Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Porras AG (1993) Clinical pharmacology of alendronate sodium. Osteoporosis Int 3(suppl 3):13-6
11. Rossini M, Gatti D, Zamberlan N, Braga V, Dorizzi R, Adami S (1994) Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis. J Bone Miner Res 9:1833-7
12. Degrossi OJ, Oliveri P, García del Río H, Labriola O, Artagaveytia D, Degrossi EB (1985) Technetium-99m APD compared with technetium-99m MDP as a bone scanning agent. J Nucl Med 26:1135-9
13. Landman JO, Schweitzer DH, Frolich M, Hamdy NAT, Papapoulos SE (1995) Recovery of serum calcium concentrations following acute hypocalcemia in patients with osteoporosis on long-term therapy with the bisphosphonate pamidronate, J Clin Endocrinol Metab 80:524-8
14. Fromm GA, Vega E, Plantalech L, Galich AM, Mautalen CA (1991) Differential action of pamidronate on trabecular and cortical bone in women wth involutional osteoporosis. Osteoprosis Int 1:129-33
15. Devogelaer JP, Nagant de Deuxchaisnes C (1990) Treatment of involutional osteoporosis with the bisphosphonate APD (disodium pamidronate): non-linear increase of lumbar bone mineral density. J Bone Miner Res 5:251.
16. Reitsma PH, Bijvoet OLM, Potokar M, van der Wee-Pals LJA, van Wijk-van Lennep MML (1983) Apposition and resorption of bone during oral treatment with (3-amino-1-hydroxypropylidene) 1.1-bisphosphonate [APD]. Calcif Tissue Int 35:357-61