Inhibitory effects of scopadulcic acid B and its derivatives on bone resorption and osteoclast formation in vitro

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 9, 1996, Pages 1037-1042

  Miyahara, Tatsuro ^a   Hayashi, Toshimitsu ^a   Matsuda, Shuzo ^a   Yamada, Ryuichi ^a   Ikeda, Koichi ^a   Tonoyama, Harumi ^a   Komiyama, Hiroko ^a   Matsumoto, Masaaki ^a   Nemoto, Nobuo ^a   Sankawa, Ushio ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE; SCOPADULCIC ACID A; SCOPADULCIC ACID DERIVATIVE; SCOPADULCIOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS;

EID: 0029899664     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00173-4     Document Type: Article

References (18)

1. Raisz, L. G. New Eng. J. Med. 1988, 318, 818.
2. Baron, R, Anac. Rec. 1989, 224, 317.
3. Blair, H. C.; Teitelbaum, S. C.; Ghiselei, R.; Gluck, S. Science 1989, 245, 855.
4. Mattson, J. P.; Väänänen, K.; Wallmark, B.; Lorenzon, P. Biochim. Biophys. Acta 1991, 1065, 261.
5. a) Tuukkanen, J.; Väänänen, H. K. Calcif. Tissue Int. 1986, 38, 123.
6. b) Sarges, R.; Gallagher, A.; Chambers, T. J.; Yeh, L.-A. J. Med. Chem. 1993, 36, 2828.
7. a) Hayashi, T.; Kishi, M.; Kawasaki, M.; Arisawa, M.; Shimizu, M.; Suzuki, S.; Yoshizaki, M.; Morita, N.; Tezuka, Y.; Kikuchi, T.; Berganza, L. H.; Ferro, E.; Basualdo, I. Tetrahedron Lett. 1987, 28, 3693.
8. b) Hayashi, T.; Asano, S.; Mizutani, M.; Takeguchi, N.; Kojima, T.; Okamura, K.; Morita, N. J. Nat. Prod. 1991, 54, 802.
9. Asano, S.; Mizutani, M.; Hayashi, T.; Morita, N.; Takeguchi, N. J. Biol. Chem. 1990, 265, 22167.
10. Hayashi, T.; Sugimoto, T.; Takewaki, N.; Takeguchi, N.; Tran, V. D.; O'Connor, S. J.; Rucker, P. V.; Overman, L. E. Bioorg. Med. Chem. Lett. 1995, 5, 2943.
11. Hayashi, T.; Hayashi, K.; Uchida, K.; Niwayama, N.; Morita, N. Chem. Pharm. Bull. 1990, 38, 239.
12. 2O at 5 °C to yield SDC together with compounds 17 and 18.
13. Shigeno, C.; Yamamoto, I.; Dokoh, H.; Hino, M.; Aoki, J.; Yamada, K.; Morita, R.; Kanyama, M.; Torizuka, K. J. Clin. Endoclinol. Metab. 1985, 61, 761.
14. Takahashi, N.; Akatsu, T.; Udagawa, N.; Sasaki, T.; Yamaguchi, A.; Moseley, J. M.; Martin, T. J.; Suda, T. Endocrinology 1988, 123, 2600.
15. Burstone, M. S. J. Natl. Cancer Inst. 1958, 21, 523.
16. a) Nijweide, P. J.; Burger, E. H.; Feyen, J. H. M. Physiol. Rev. 1986, 66, 855.
17. b) McSheehy, P. M. G.; Chambers, T. J. J. Clin. Invest. 1987, 80, 425.
18. c) Takahashi, N.; Yamana, H.; Yoshiki, S.; Roodman, G. D.; Mundy, G. R.; Jones, S. J.; Boyde, A.; Suda, T. Endocrinology 1988, 122, 1373.