Spouses of demented patients with low cobalamin levels: A new risk group for cobalamin deficiency

European Journal of Haematology

Volumn 57, Issue 1, 1996, Pages 62-67

  Carmel, R ^a   Cairo, K ^b   Bondareff, W ^b   Gott, P S ^b   Cummings, J L ^b   Henderson, V W ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

Cobalamin deficiency; Dementia; Homocysteine; Methylmalonic acid; Relatives

Indexed keywords

COBALAMIN;

ADULT; AGED; ARTICLE; DEMENTIA; DISEASE ASSOCIATION; FAMILY HISTORY; FEMALE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; SCREENING TEST; VITAMIN BLOOD LEVEL; VITAMIN DEFICIENCY;

EID: 0029899479     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1996.tb00491.x     Document Type: Article

References (28)

1. 12 concentrations of normals and of patients with megaloblastic anaemias and other diseases. J Clin Pathol 1952: 5: 129-139.
2. 12: correlation of serum concentrations and age. Proc Soc Exp Biol Med 1955: 89: 375-378.
3. NILSSON-EHLE H, LANDAHL S, LINDSTEDT G, et al. Low serum cobalamin levels in a population study of 70- and 75-year-old subjects. Gastrointestinal causes and hematological effects. Digest Dis Sci 1989: 34: 716-723.
4. 12 and folate levels in the elderly. J Am Geriatr Soc 1991: 39: 1155-1159.
5. 12 in Alzheimertype dementia. Age Ageing 1984: 13: 101-105.
6. KARNAZE DS, CARMEL R. Low serum cobalamin levels in primary degenerative dementia: do some patients harbor atypical cobalamin deficiency states? Arch Intern Med 1987: 147: 429-431.
7. 12 levels related to high activity of platelet monoamine oxidase in patients with dementia disorders. Acta Psychiatr Scand 1988: 78: 451-457.
8. CARMEL R, GOTT PS, WATERS CH, et al. The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities. Eur J Haematol 1995: 54: 245-253.
9. CARMEL R, KARNAZE DS. The deoxyuridine suppression test identifies subtle cobalamin deficiency in patients without typical megaloblastic anemia. JAMA 1985: 253: 1284-1287.
10. CARMEL R, SINOW RM, KARNAZE DS. Atypical cobalamin deficiency: subtle biochemical evidence of deficiency is commonly demonstrable in patients without megaloblastic anemia and is often associated with protein-bound cobalamin malabsorption. J Lab Clin Med 1987: 109: 454-463.
11. CARMEL R. Reversal by cobalamin therapy of minimal defects in the deoxyuridine suppression test in patients without anemia: further evidence for a subtle metabolic cobalamin deficiency. J Lab Clin Med 1992: 119: 240-244.
12. PENNYPACKER LC, ALLEN RH, KELLY JP, et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992: 40: 1197-1204.
13. JOOSTEN E, PELEMANS W, DEVOS P, et al. Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin. Eur J Haematol 1993: 51: 25-30.
14. KARNAZE DS, CARMEL R. Neurological and evoked potential abnormalities in subtle cobalamin deficiency states, including those without anemia and with normal absorption of free cobalamin. Arch Neurol 1990: 47: 1008-1012.
15. 12 deficiency? J Am Geriatr Soc 1988: 36: 1105-1112.
16. CARMEL R, KARNAZE DS, WEINER JM. Neurologic abnormalities in cobalamin deficiency are associated with higher cobalamin "analogue" values than are hematologic abnormalities. J Lab Clin Med 1988: 111: 57-62.
17. SAS LANGUAGE. Reference, Version 6, 1st edn. Cary, NC: SAS Institute, Inc.; 1990.
18. RASMUSSEN K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989: 35: 260-264.
19. JACOBSEN DW, GATAUTIS VJ, GREEN R, et al. Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem 1994: 40: 873-881.
20. CARMEL R, SINOW RM, SIEGEL ME, SAMLOFF IM. Food cobalamin malabsorption occurs frequently in patients with unexplained low serum cobalamin levels. Arch Intern Med 1988: 148: 1715-1719.
21. 12 and folate deficiency. Blood 1978: 51: 119-128.
22. WICKRAMASINGHE SN, SAUNDERS JE. Results of three years' experience with the deoxyuridine suppression test. Acta Haematol 1977: 58: 193-206.
23. MORRIS JC, MOHS RC, ROGERS H, FILLENBAUM G, HEYMAN A. Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. Psychopharm Bull 1988: 24: 641-652.
24. CARMEL R. Subtle and atypical cobalamin deficiency states. Am J Hematol 1990: 34: 108-114.
25. CARMEL R, PEREZ-PEREZ GI, BLASER MJ. Helicobacter pylori infection and food-cobalamin malabsorption. Digest Dis Sci 1994: 39: 309-314.
26. BUTLER RN, LEWIS M, SUNDERLAND T. Aging and Mental Health. Positive Psychological and Biomedical Approaches, 4th edn. New York: McMillan: 1991: 321.
27. HOWARD JM, AZEN C, GREEN R, JACOBSEN DW, CARMEL R. Suboptimal dietary intake of cobalamin does not explain the frequently abnormal serum cobalamin and metabolite levels in the elderly. Blood 1995: 86 (suppl 1): 636a.
28. WINOGRAD CH, JACOBSON DH, BUTTERFIELD GE, et al. Nutritional intake in patients with senile dementia of the Alzheimer type. Alzheimer Dis Assoc Disord 1991: 5: 173-180.