Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats

Brazilian Journal of Medical and Biological Research

Volumn 29, Issue 6, 1996, Pages 793-796

  Hessel, G ^a   De Santi Neto, D ^a   Collates, E F ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

acetaminophen; aminotransferase; hepatic necrosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; PARACETAMOL; SUCROSE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; INTOXICATION; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ACETAMINOPHEN; ACUTE DISEASE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; FASTING; LIVER DISEASES; MALE; NECROSIS; RATS; RATS, WISTAR; SUCROSE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0029899306     PISSN: 0100879X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Gabrieli ER & Orfanos A (1968). Effect of carbon tetrachloride on serum glutamicoxalacetic transaminase isoenzymes. Proceedings of the Society for Experimental Biology and Medicine. 127: 766-770.
2. Cutler MG (1974). The sensitivity of function tests in detecting liver damage in the rat. Toxicology and Applied Pharmacology. 28: 349-357.
3. Dixon MF, Fulker MJ, Walker BE, Kelleher J & Losowsky MS (1975). Serum transaminase levels after experimental paracetamol-induced hepatic necrosis. Gut, 16: 800-807.
4. Jollow DJ, Thorgeirsson SS, Potter WZ, Hashimoto M & Mitchell JR (1974). Acetaminophen-induced hepatic necrosis. Pharmacology. 12: 251-271.
5. Mitchell JR, Jollow DJ, Potter WZ, Gillette JR & Brodie BB (1973). Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. Journal of Pharmacology and Experimental Therapeutics, 187: 211-217.
6. Pessayre D, Dolder A, Artigou JY, Wandscheer JC, Descatoire V, Degott C & Benhamou JP (1979). Effect of fasting on metabolite-mediated hepatotoxicity in the rat. Gastroenterology, 77: 264-271.
7. Martinelli ALC, Meneghelli UG, Zucoloto S & Lima SO (1989). Effect of the intake of an exclusive sucrose diet on acetaminophen hepatotoxicity in rats. Brazilian Journal of Medical and Biological Research. 22: 1381-1387.
8. Martinelli ALC, Meneghelli UG & Zucoloto S (1993). Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion. Brazilian Journal of Medical and Biological Research, 26: 989-998.
9. Portmann B, Talbot IC, Day DW, Davidson AR, Murray-Lyon IM & Williams R (1975). Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters. Journal of Pathology, 117: 169-180.
10. Zelman S, Wang CC & Appelhanzl (1959). Transaminases in serum and liver correlated with liver cell necrosis in needle aspiration biopsies. American Journal of the Medical Sciences, 237: 323-334.
11. James O, Roberts SH, Douglas AP, Lesna M, Pulman L, Smith PA & Watson AJ (1975). Liver damage after paracetamol overdose - comparison of liver-function tests, fasting serum bile acids, and liver histology. Lancet, 2: 579-581.
12. Siegel S (1975). O coeficiente de correlação por postos de Spearman. In: Siegel S (Editor), Estatistica NãoParamétrica. McGraw-Hill, São Paulo, 228-240.
13. Martinelli ALC (1986). Alterações bioqui'micas relacionadas à função hepática, influência da via de administração e de dieta exclusiva de sacarose nas lesões do fígado induzidas experimentalmente pelo acetaminofen. Master's thesis, FMRP, Ribeirão Preto.
14. Lawson TA & Pound AW (1974). The different susceptibility of rat liver lobes to carbon tetrachloride and dimethylnitrosamine. British Journal of Experimental Pathology, 55: 583-588.