Inhibition by tetranactin of interleukin 1β- and cyclic AMP-induced nitric oxide synthase expression in rat renal mesangial cells

British Journal of Pharmacology

Volumn 118, Issue 7, 1996, Pages 1621-1626

  Kunz, Dieter ^a   Walker, Gaby ^a   Wiesenberg, Irmgard ^b   Pfeilschifter, Josef ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Cyclic AMP; Interleukin 1; Nitric oxide; Nitric oxide synthase; Tetranactin

Indexed keywords

ANTIBIOTIC AGENT; BUCLADESINE; CYCLIC AMP; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NITRITE; TETRANACTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INDUCTION; IMMUNOBLOTTING; MESANGIUM CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOMYCES;

EID: 0029898191     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15583.x     Document Type: Article

References (36)

1. ANGGARD, E. (1994). Nitric oxide: mediator, murderer and medicine. Lancet, 343, 1199-1206.
2. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
3. CALLEWAERT, D.M., RADCLIFF, G., TANOUCHI, Y. & SHICHI, H. (1988). Tetranactin, a macrotetrolide antibiotic, suppresses in vitro proliferation of human lymphocytes and generation of cytoxicity. Immunopharmacol., 16, 25-32.
4. CATTELL, V. & COOK, T. (1995). The nitric oxide pathway in glomerulonephritis. Curr. Opinion Nephrol. Hypertens., 4, 359-364.
5. CORBETT, J.A., TILTON, R.G., CHANG, K., HASAN, K.S., IDO, Y., WANG, J.L., SWEETLAND, M.A., LANCASTER, JR. J.R., WILLIAMSON, J.R. & MCDANIEL, M.L. (1992). Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes, 41, 552-556.
6. GARVEY, E.P., OPLINGER, J.A., TANOURY, G.J., SHERMAN, P.A., FOWLER, M., MARSHALL, S., HARMON, M.F., PAITH, J.E. & FURFINE, E.S. (1994). Potent and selective inhibition of human nitric oxide synthase. J. Biol. Chem., 269, 26669-26676.
7. 15N] nitrate in biological fluids. Anal. Biochem., 126, 131-138.
8. GRIFFITH, M.J.D., MESSENT, M., MACALLISTER, R.J. & EVANS, T.W. (1993). Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br. J. Pharmacol., 110, 963-968.
9. KLEMM, P., HECKER, M., STOCKHAUSEN, H., WU, C.C. & THIEMERMANN, C. (1995). Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat. Br. J. Pharmacol., 115, 1175-1181.
10. KNOWLES, R.G. & MONCADA, S. (1994). Nitric oxide synthase in mammals. Biochem. J., 298, 249-258.
11. KUNZ, D., MÜHL, H., WALKER, G. & PFEILSCHIFTER, J. (1994a). Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells. Proc. Natl. Acad. Sci. U.S.A., 91, 5387-5391.
12. KUNZ, D., WALKER, G., EBERHARDT, W., NITSCH, D. & PFEILSCHIFTER, J. (1995). Interleukin 1β-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A. Biochem. Biophys. Res. Commun., 216, 438-446.
13. KUNZ, D., WALKER, G., EBERHARDT, W. & PFEILSCHIFTER, J. (1996). Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1β-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation. Proc. Natl. Acad. Sci. U.S.A., 93, 255-259.
14. KUNZ, D., WALKER, G. & PFEILSCHIFTER, J. (1994b). Dexamethasone differentially affects interleukin 1β- and cAMP-induced nitric oxide synthase expression in rat mesangial cells. Biochem. J., 304, 337-340.
15. MARSDEN, P.A. & BALLERMANN, B.J. (1990). Tumor necrosis factor α activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism. J. Exp. Med., 172, 1843-1852.
16. MASON, J. (1989). Pharmacology ofcyclosporin (sandimmune). VII. Pathophysiology and toxicology of cyclosporine in humans and animals. Pharmacol. Rev., 41, 423-434.
17. MISKO, T.P., MOORE, W.M., KASTEN, T.P., NICKOLS, G.A., CORBETT, J.A., TILTON, R.G., MCDANIEL, M.L., WILLIAMSON, J.R. & CURRIE, M.G. (1993). Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol., 233, 119-125.
18. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 109-142.
19. MÜHL, H., KUNZ, D. & PFEILSCHIFTER, J. (1994). Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP. Br. J. Pharmacol., 112, 1-8.
20. MÜHL, H., KUNZ, D., ROB, P. & PFEILSCHIFTER, J. (1993). Cyclosporin derivatives inhibit interleukin 1β induction of nitric oxide synthase in renal mesangial cells. Eur. J. Pharmacol., 249, 95-100.
21. MÜHL, H. & PFEILSCHIFTER, J. (1994). Possible role of protein kinase C-ε isoenzyme in inhibition of interleukin 1β induction of nitric oxide synthase in rat renal mesangial cells. Biochem. J., 303, 607-612.
22. NATHAN, C. (1992). Nitric oxide as a secretory product of mammalian cells. FASEB J., 6, 3051-3064.
23. NATHAN, C. & XIE, Q.-W. (1994). Regulation of biosynthesis of nitric oxide. J. Biol. Chem., 269, 13725-13728.
24. PFEILSCHIFTER, J. (1989). Cross-talk between transmembrane signalling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells. Eur. J. Clin. Invest., 19, 347-361.
25. PFEILSCHIFTER, J. (1991). Anti-inflammatory steroids inhibit cytokine induction of nitric oxide synthase in rat renal mesangial cells. Eur. J. Pharmacol., 195, 179-180.
26. PFEILSCHIFTER, J. (1994). Mesangial cells orchestrate inflammation in the renal glomerulus. News Physiol. Sci., 9, 271-276.
27. PFEILSCHIFTER, J. (1995). Does nitric oxide, an inflammatory mediator of glomerular mesangial cells, have a role in diabetic nephropathy? Kidney Int., 48, S50-S60.
28. PFEILSCHIFTER, J., ROB, P., MÜLSCH, A., FANDREY, J., VOSBECK, K. & BUSSE, R. (1992). Interleukin 1β and tumour necrosis factor α induce a macrophage-type of nitric oxide synthase in rat renal mesangial cells. Eur. J. Biochem., 203, 251-255.
29. PFEILSCHIFTER, J. & SCHWARZENBACH, H. (1990). Interleukin 1 and tumour necrosis factor stimulate cGMP in rat renal mesangial cells. FEBS Lett., 273, 185-187.
30. SAMBROCK, J., FRITSCH, J. & MANIATIS, T. (1989). Molecular Cloning, a Laboratory Manual (Cold Spring Harbor, N.Y., Cold Spring Harbor Laboratory Press).
31. SCHREIBER, S.L. & CRABTREE, G.R. (1992). The mechanism of action of cyclosporin A and FK 506. Immunol. Today, 13, 136-142.
32. SZABO, C., SOUTHAN, G.J. & THIEMERMANN, C (1994). Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc. Natl. Acad. Sci. U.S.A., 91, 12472-12476.
33. TANOUCHI, Y. & SHICHI, H. (1988). Immunosuppressive and anti-proliferative effects of a macrotetrolide antibiotic, tetranactin. Immunology, 63, 471-475.
34. TEUNISSEN, M., PISTOOR, F.H.M., RONGEN, H.A.H., KASPENBERG, M.L. & BOS, J.D. (1992). A comparison of the inhibitory effects of immunosuppressive agents cyclosporin, tetranactin, and didemnin B on human T cell responses in vitro. Transplantation, 53, 875-881.
35. TSCHAIKOWSKY, K., MEISNER, M., SCHÖNHUBER, F. & RÜGHEIMER, E. (1994). Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br. J. Pharmacol., 113, 664-668
36. WU, C.C., THIEMERMANN, C. & VANE, J.R. (1995). Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat. Br. J. Pharmacol., 114, 1273-1281.