Influence of age on cholinergic and inhibitory nonadrenergic noncholinergic responses in the rat ileum

European Journal of Pharmacology

Volumn 303, Issue 1-2, 1996, Pages 79-86

  Smits, Geert J M ^a   Lefebvre, Romain A ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Aging; ATP; Ileum, rat; Nitric oxide (NO); Non adrenergic non cholinergic (NANC)

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ATROPINE; CYCLIC AMP; CYCLIC GMP; GUANETHIDINE; METHACHOLINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHYSOSTIGMINE; PROSTAGLANDIN F2 ALPHA;

AGE; AGED; ANIMAL TISSUE; ARTICLE; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DESENSITIZATION; DOSE TIME EFFECT RELATION; ELECTROSTIMULATION; ILEUM; MALE; MYENTERIC PLEXUS; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE;

EID: 0029898110     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00089-1     Document Type: Article

References (29)

1. Atkinson, J., R. Tatchum-Talom and C. Capdeville-Atkinson, 1994, Reduction of endothelial function with age in the mesenteric arterial bed of the normotensive rat, Br. J. Pharmacol. 111, 1184.
2. Barthò, L., G. Kóczán, G. Pethö and C.A. Maggi, 1992, Blockade of nitric oxide synthase inhibits nerve-mediated contractions in the rat small intestine, Neurosci. Lett. 145, 43.
3. Belai, A., S. Cooper and G. Burnstock, 1995, Effect of age on NADPH-diaphorase-containing myenteric neurones of rat ileum and proximal colon, Cell Tissue Res. 279, 379.
4. Butt, W.G., M. Wang, S.T. Kaufman, J.P. Ryan and S. Cohen, 1993, Age-related changes in rat colon mechanisms, J. Gastrointest. Mot. 5, 123.
5. Costa, M. and J.B. Furness, 1982, Nervous control of intestinal motility, in: Mediators and Drugs in Gastrointestinal Motility I, ed. G. Bertaccini (Springer, Berlin) p. 279.
6. Desouza, R.R., H.B. Moratelli, N. Borges and E.A. Liberti, 1993, Age-induced nerve cell loss in the myenteric plexus of the small intestine in man, Gerontology 39, 183.
7. Gabella, G., 1989, Fall in the number of myenteric neurons in aging guinea pigs, Gastroenterology 96, 1487.
8. Keim, M. and J. Schrader, 1990, Control of coronary vascular tone by nitric oxide, Circ. Res. 66, 1561.
9. Kobashi, Y.L., E.P. Breuing and R.P. Markus, 1985, Age-related changes in the reactivity of the rat jejunum to cholinoceptor agonist, Eur. J. Pharmacol. 115, 133.
10. Kupfer, R.M., M. Heppel, J.W. Haggith and D.N. Bateman, 1985, Gastric emptying and small-bowel transit rate in elderly, J. Am. Geriatr. Soc. 33, 340.
11. Lowry, O.H., N.J. Rosebrough and A.L. Farr, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193, 265.
12. Ludbrook, J., 1991, On making multiple comparisons in clinical and experimental pharmacology and physiology, Clin. Exp. Pharmacol. Physiol. 18, 379.
13. McDougal, J.N., M.S. Miller, T.F. Burks and D.L. Kreulen, 1984, Age-related changes in colonic function in rats, Am. J. Physiol. 247, G542.
14. Masoro, E.J., 1991, Biology of aging: facts, thoughts, and experimental approaches, Lab. Invest. 65, 500.
15. Moritoki, H., A. Tanioka, Y. Maeshiba, T. Iwamoto, Y. Ishida and H. Araki, 1988, Age-associated decrease in histamine-induced vasodilation may be due to reduction of cyclic GMP formation, Br. J. Pharmacol. 95, 1015.
16. Nakatsu, K. and J. Diamond, 1988, Role of cGMP in relaxation of vascular and other smooth muscle, Can. J. Physiol. Pharmacol. 67, 251.
17. Nowak, T.V., B. Harrington and J. Kalbfleisch, 1990, Age-related changes in enteric neuromuscular transmission, J. Pharmacol. Exp. Ther. 253, 683.
18. Paton, W.D.M. and E.S. Vizi, 1969, The inhibitory actions of noradrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip, Br. J. Pharmacol. 25, 10.
19. Santer, R.M. and D.M. Baker, 1988, Enteric neuron numbers and sizes in Auerbach's plexus in the small and large intestine of adult and aged rats, J. Aut. Nerv. Syst. 25, 59.
20. Smits, G.J.M. and R.A. Lefebvre, 1992, Influence of age on responsiveness of the rat gastric fundus to agonist and to stimulation of intrinsic nerves, Eur. J. Pharmacol. 223, 97.
21. Smits, G.J.M. and R.A. Lefebvre, 1995, Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus, Br. J. Pharmacol. 114, 640.
22. Smits, G.J.M. and R.A. Lefebvre, 1996a, ATP and nitric oxide: inhibitory NANC neurotransmitters in the longitudinal muscle-myenteric plexus preparation of the rat ileum, Br. J. Pharmacol. 118 (in press).
23. Smits, G.J.M. and R.A. Lefebvre, 1996b, Influence of aging on gastric emptying of liquids, small intestine transit and faecal output in rats, Exp. Gerontol. (in press).
24. Smits, G.J.M., K. Buyukafşar and R.A. Lefebvre, 1995, NANC relaxation in the rat longitudinal muscle-myenteric plexus preparation: neurotransmitter(s) involved and influence of aging, Acta Gastroenterol. Belg. 57, B2.
25. Tovey, K.C., K.G. Oldham and J.A.M. Whelan, 1974, A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique, Clin. Chim. Acta 56, 221.
26. Tsai, C.S. and R.F. Ochillo, 1987, The effect of aging on the responsiveness of the cholinergic receptor of the longitudinal muscle of guinea-pig isolated ileum, Res. Commun. Chem. Pathol. Pharmacol. 55, 275.
27. Varga, F., 1976, Transit time changes with age in the gastrointestinal tract of the rat, Digestion 14, 319.
28. Waldman, S.A. and F. Murad, 1987, Cyclic GMP synthesis and function, Pharmacol. Rev. 39, 163.
29. Waterman, S.A. and M. Costa, 1994, The role of enteric inhibitory motoneurons in peristalsis in the isolated guinea-pig small intestine, J. Physiol. 477, 459.