Inorganic tin - A new selective inducer of the murine coumarin 7-hydroxylase (CYP2A5)

Toxicology

Volumn 108, Issue 1-2, 1996, Pages 73-78

  Emde, Birgit ^a   Tegtmeier, Martin ^b   Hahnemann, Birger ^a   Legrum, Wolfgang ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Schaper & Brummer GmbH & Co KG   (Germany)

Author keywords

Coumarin; Coumarin 7 hydroxylase; CYP2A5; Inorganic tin; Kidney; Selective coumarin 7 hydroxylase inducer; Stannous chloride

Indexed keywords

3 METHYLCHOLANTHRENE; AMITROLE; COBALT CHLORIDE; CYTOCHROME P450 ISOENZYME; PHENOBARBITAL; PYRAZOLE; TIN CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; KIDNEY; MALE; METYRAPONE; MICE; MICROSOMES; MIXED FUNCTION OXYGENASES; TIN COMPOUNDS;

ANIMALIA; MURINAE;

EID: 0029898024     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(95)03285-N     Document Type: Article

References (22)

1. Aitio, A. (1978) A simple and sensitive assay of 7-ethoxy-coumarin deethylation. Anal. Biochem. 85, 488-491.
2. Arvela, P., Kraul, H., Stenbäk, F. and Pelkonen O. (1991) The cerium-induced liver injury and oxidative drug metabolism in DBA/2 and C57B1/6 mice. Toxicology 69, 1-9.
3. ATSDR (Agency for Toxic Substances and Disease Registry) US. (1992) Department of Health and Human Services. Toxicological profile for tin. TP-91/27, 1-148.
4. Emde, B., Tegtmeier, M., Hahnemann, B. and Legrum W. (1991) Induction of the murine coumarin 7-hydroxylase by tin-time-and dose-dependent. Naunyn-Schmiedeberg's Arch. Pharmacol. 344, R106.
5. Feil, F., Tegtmeier, M., Hahnemann, B. and Legrum, W. (1992) Interactions of coumarin-metabolizing cytochrome P450 isozymes with analogues of umbelliferone. Pharm. Pharmacol. Lett. 2, 43-46.
6. Hahnemann, B., Kühn, B., Heubel, F. and Legrum, W. (1989) Selective induction of the coumarin hydroxylase by N-containing heteroaromatic compounds. Arch. Toxicol. Suppl. 13, 297-301.
7. Hahnemann, B., Salonpää, P., Pasanen, M., Mäenpää, J., Honkakoski, P., Juvonen, R., Lang, M.A., Pelkonen, O. and Raunio, H. (1992) Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. Biochem. J. 286, 289-294.
8. Hennighausen, G., Lange, P. and Merkord, J. (1980) The relationship between the length of alkyl chain of dialkyltin compounds and their effects on thymus and bile ducts in mice. Arch. Toxicol. Suppl. 4, 175-178.
9. Honkakoski, P., Fasanen, M., Mäenpää, J., Leikola, J., Juvonen, R., Lang, M.A., Pelkonen, O. and Raunio, H. (1993) Cytochrome P4502A-mediated coumarin 7-hydroxylation and testosterone hydroxylations in the rat lung. Pharmacol. Toxicol. 72, 107-112.
10. Juvonen, R., Kaipainen, P.K. and Lang, M.A. (1985) Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice. Eur. J. Biochem. 152, 3-8.
11. Kappas, A. and Drummond, G.S. (1984) Control of heme and cytochrome P-450 metabolism by inorganic metals, organometals and synthetic metalloporphyrins. Environ. Health Perspect. 57, 301-306.
12. Kazantzis, G. (1994) Tin. In: L. Alessio, A. Berlin, R. Roi, M.T. van der Venne (Eds), Biological Indicators for the Assessment of Human Exposure to Industrial Chemicals, European Commission, Vol. 7, EUR 14815, pp. 93-101.
13. Kocer, Z., Raunio, H., Pasanen, M., Arvela, P., Raiskila, T., Honkakoski, P., Lang, M.A., Negishi, M. and Pelkonen, O. (1991) Comparison between cobalt and pyrazole in the in-creased expression of coumarin 7-hydroxylase in mouse liver. Biochem. Pharmacol. 41, 461-465.
14. Legrum, W., Emde, B. and Netter, K.J. (1994) Influences of tin on the murine coumarin 7-hydroxylases of different target organs. Can. J. Physiol. Pharmacol. 72 (Suppl. 1), 584 (P22.1.15).
15. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265-275.
16. Mangoura, S.A., Strack, A., Legrum, W. and Netter, K.J. (1989) Indium selectively increases the cytochrome P-450 dependent O-dealkylation of coumarin derivatives in male mice. Naunyn-Schmiedeberg's Arch. Pharmacol. 399, 586-602.
17. Netter, K.J. (1960) Eine Methode zur direkten Messung der O-Demethylierung in Lebermikrosomen und ihre Anwendung auf die Mikrosomenhemmwirkung von SKF 525-A. Naunyn-Schmiedebergs Arch. Exp. Path. Pharmakol. 238, 292-300.
18. Netter, K.J., Sippmann, M. and Legrum, W (1995) Combinations of Coh-inducers influence the coumarin 7-hydroxylase activity and its Cyp2a-4/5-mRNA. Naunyn-Schmiedeberg's Arch. Pharamacol. 351 (Suppl.), R56.
19. Omura, T. and Sato, R. (1964) The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem. 239, 2370-2378.
20. Sacerdoti, D., Escalante, B., Abraham, N.G., McGiff, J.C., Levere, R.D. and Schwartzman, M.L. (1989) Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science 243, 388-390.
21. Salonpää, P., Iscan, M., Fasanen, M., Arvela, P., Pelkonen, O. and Raunio, H. (1992) Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P450 2a-4/5) expression in the liver and kidneys of inbred mice. Biochem. Pharmacol. 44, 1269-1274.
22. Venugopal, B. and Luckey, T.D. (1979) Metal Toxicity in Mammals, Vol. 2, Plenum Press, New York, pp. 180-185.