The HLA associated predisposition to type 1 diabetes and other autoimmune diseases

Journal of Pediatric Endocrinology and Metabolism

Volumn 9, Issue SUPPL. 1, 1996, Pages 75-88

  Thorsby, Erik ^a,b   Undlien, Dag ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN;

AUTOIMMUNITY; CONFERENCE PAPER; DISEASE PREDISPOSITION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS;

EID: 0029897703     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/jpem.1996.9.s1.75     Document Type: Conference Paper

References (52)

1. Tiwari JL, Terasaki PI. HLA and Disease Associations. New York: Springer Verlag, 1985.
2. Thorsby E, Rønningen KS. Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1993; 36: 371-377.
3. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130-136.
4. Bennett ST, Lucassen AM, Gough SCL, Powell EE, et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus Nature Genetics 1995; 9: 284-292.
5. Undlien ED, Bennett ST, Todd JA, Akselen HE, et al. Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene. Diabetes 1995; 44: 620-626.
6. Campbell RD, Trowsdale J. Map of the human MHC. Immunol Today 1994; 14: 349-352.
7. Bodmer JG, Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 1995. Tissue Antigens 1995; 46: 1-18.
8. Bjørkman PJ, Saper MA, Samraoui B, Bennet WS, et al. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens Nature 1987; 329: 512-518.
9. Brown JH, Jardetzky TS, Gorga JC, Stern LJ, et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993; 364: 33-39.
10. Elliot T, Smith M, Driscoll P, McMichael A. Peptide selection by class I molecules of the major histocompatibility complex Current Biology 1993; 3. 854-866.
11. Engelhard V. Structure of peptides associated with class I and class II MHC molecules. Ann Rev Immunol 1994; 12: 181-207.
12. Germain RN. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation. Cell 1994; 76: 287-299.
13. Rammensee HG, Friede T, Stevanovic S. MHC ligands and peptide motifs: first listing. Immunogenetics 1995, 41: 178-228.
14. Sloan VS, Cameron P, Porter G, Gammon M, et al. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 1995; 375: 802-806.
15. Thorsby E. HLA-associated disease susceptibility. Which genes are primarily involved? Immunologist 1995; 3: 51-58.
16. Singal DP, Blachman MA. Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 1973; 22: 429-432.
17. Nerup J, Platz P, Andersen OO, Christy M, et al. HL-A antigens and diabetes mellitus. Lancet 1974; ii. 864-866.
18. Nerup J, Cathelineau C, Signalet J, Thomsen M. HLA and endocrine diseases. In: Dausset J, Svejgaard A, eds. HLA and Disease. Copenhagen: Munksgaard, 1977; 149-167.
19. Owerbach D, Gunn S, Gabbay KH. Primary association of HLA-DQ8 with type 1 diabetes in DR4 patients. Diabetes 1989; 38: 942-945
20. Rønningen KS, Spurkland A, Tait BD, Drummond B, et al. HLA class II association in insulin-dependent diabetes mellitus among Blacks, Caucasoids and Japanese. In HLA 1991, vol 1. Oxford University Press, 1992, 713-722.
21. Rønningen KS, Spurkland A, Vartdal F, Thorsby E. Distribution of HLA-DRB1, -DQA1 and DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus. Tissue Antigens 1991; 37: 105-111.
22. Sanjeevi CD, Landin-Olsson M, Kockum I, Dahlquist G, Lermark Å. Effects of the second HLA-DQ haplotype on the association with childhood insulin-dependent diabetes. Tissue Antigens 1995; 45: 148-152.
23. Cucca F, Muntoni F, Lampis R, Frau F, et al. Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. Hum Immunol 1993; 37: 85-94.
24. Dubois D, Timsit J, Boitard C, Bach JF, Caillat-Zucman S. Immunogenetics of IDDM in non-DR3/non-DR4 patients Autoimmunity 1995; 21: 14.
25. Zeliszewski D, Tiercy J-M, Boitard C, Gu X-F, et al Extensive study of DRB, DQA, and DQB gene polymorphism in 23 DR2-positive, insulin-dependent diabetes mellitus patients. Hum Immunol 1992, 33. 140-147.
26. Todd JA, Bell JI, McDevitt HO. HLA-DQβ gene contributions to susceptibility and resistance to insulin-dependent diabetes mellitus Nature 1987; 329: 599-604.
27. Khalil I, D'Akuriol L, Gobet M, Morin L, et al. A combination of HLA-DQβ Asp57-negative and HLA DQα Arg52 confers susceptibility to insulin-dependent diabetes mellitus. J Clin Invest 1990; 85. 1315-1319.
28. Rønningen KS, Iwe T, Halstensen TS, Spurkland A, Thorsby E. The amino acid at position 57 of the HLA-DQβ chain and susceptibility to develop insulin-dependent diabetes mellitus. Hum Immunol 1989; 26: 215-225.
29. Lundin KEA, Rønningen KS, Aono S, Spurkland A, et al. HLA-DQ antigens and DQβ amino acid 57 of Japanese patients with insulin-dependent diabetes mellitus: Detection of a DRw8DQw8 haplotype. Tissue Antigens 1989, 34: 233-241.
30. Wucherpfennig KW, Strominger JL. Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases. J Expl Med 1995; 181: 1597-1601
31. Cucca F, Lampis R, Frau F, Macis D, et al. The distribution of DR4 haplotypes in Sardinia suggests a primary association of type 1 diabetes with DRB1 and DQB1 loci Hum Immunol 1995; 43: 301-308.
32. Auwera BVD, Waeyenberge CV, Schuit F, et al DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1* 0302/DQA1*0501-DQB1*0201 genotype Diabetes 1995; 44: 527-530.
33. Harfouch E, Timsit J, Boitard C, Bach JF, et al. Contribution of DR4 alleles to IDDM predisposition or protection is independent from DQ. Autoimmunity 1995; 21: 14.
34. Yasunaga S, Kimura A, Hamaguchi K, Rønningen, KS, Sasazuki T. Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). Tissue Antigens 1995 (in press).
35. Rønningen KS, Undlien DE, Ploski R, Maouni J, et al. Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus. Bur J Immunol 1993; 23: 1050-1056.
36. Jackson DG, Capra JD. TAP1 alleles in insulin-dependent diabetes mellitus; A newly defined centromeric boundary of disease susceptibility. Proc Natl Acad Sci USA 1993; 90: 11079-11083.
37. Cucca F, Congia M, Trowsdale J, Powis SH. Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence. Tissue Antigens 1994; 44: 234-240.
38. van Edert PM, Liblau RS, Patel SD, Fugger L, et al. Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM. Diabetes 1994; 43: 110-117.
39. Caillat-Zucman S, Daniel S, Djilali-Daiah I, Timsit J, et al. Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Hum Immunol 1995; 44: 80-87.
40. Deng GY, Muir A, Maclaren NK, She JX. Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: Population and family studies. Am J Hum Genet 1995; 56: 528-534.
41. Esposito L, Lampasona V, Bonifacio E, Bosi E, Ferrari M. Lack of association of DMB polymorphism with insulin dependent diabetes. Autoimmunity 1995; 21: 15-16
42. Leech N, Sorrentino R, McCulloch DK, Nepom GT. Ultrastructural allelic variation in HLA-DQB1 promoter elements. Hum Immunol 1995; 43: 251-258.
43. Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: Genetic mapping and role in pathogenesis. Gastroenterology 1993; 105: 910-922.
44. Sollid LM, Markussen G, Ek J, Gjerde H, et al. Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer. J Expl Med 1989; 169: 345-350.
45. Lundin KEA, Gjertsen HA, Scott H, Sollid LM, Thorsby E. Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease. Hum Immunol 1994; 41: 24-27.
46. Johansen BH, Buus S, Vartdal F, Viken H, et al Binding of peptides to HLA-DQ molecules: peptide binding properties of the disease-associated HLA-DQ (α1*0501, β1*0201) molecule. Int Immunol 1994; 6: 453-463.
47. Johansen BH, Vartdal F, Eriksen JA, Thorsby E, et al. Identification of a putative motif for binding of peptides to HLA-DQ2. Int Immunol (in press).
48. Lundin KEA, Scott H, Hansen T, Paulsen G, et al. Gliadin-specific, HLA-DQ(α1*0501,β1*0201) restricted T cells from the small intestinal mucosa of celiac disease patients J Expl Med 1993; 178: 187-196.
49. Nepom GT. A unified hypothesis for the complex genetics of HLA associations with IDDM. Diabetes 1990; 39: 1153-1156.
50. Pugliese A, Gianani R, Moromisato R, Awdeh ZL, et al. HLA-dQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes 1995; 44: 608-613.
51. Böhme J, Brenden N, Rietz C, Pilström B. Dominant disease protection in MHC transgenic NOD mice More than one mechanism? Immunologist 1995; 3: 45-50.
52. Wucherpfennig KW, Stronminger JL, Molecular mimicry in the T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995; 80: 695-705.