A clinical nude mouse metastatic model for highly malignant human pancreatic cancer

Anticancer Research

Volumn 16, Issue 2, 1996, Pages 627-632

  An, Zili ^a   Wang, Xiaoen ^a   Kubota, Tetsuro ^b   Moossa, A R ^c   Hoffman, Robert M ^c,d  

^a ANTICANCER INC   (United States)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NONE   (United States)

Author keywords

Human pancreatic cancer; Metastatic model; Nude mouse

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; FLUOROURACIL; MITOMYCIN C; PYRIMIDINE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CONTROLLED STUDY; DRUG EFFICACY; EXPERIMENTAL NEOPLASM; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY METASTASIS; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PANCREAS CANCER; PRIORITY JOURNAL;

ADENOCARCINOMA; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; DISEASE MODELS, ANIMAL; FLUOROURACIL; HUMANS; LYMPHATIC METASTASIS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOMYCIN; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; RANDOM ALLOCATION; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0029897543     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Brennan M, Kinsella T and Friedman M: Cancer of the pancreas. In: Devita V, Hellman S and Rosenberg, S, eds. Cancer Principles and Practice of Oncology, ed. 3. Philadelphia: JB Lippincott Co., 1989: 800-835.
2. Arbudk SG: Chemotherapy for pancreatic cancer. Baillieres Clinical Gastroenterology 4(4): 935-968, 1990.
3. Fu X, Guadagni F and Hoffman RM: A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically from histologically-intact patient specimens. Proc Natl Acad Sci USA 89: 5645-5649, 1992.
4. Hoffman RM: Patient-like models of cancer in mice: A review and critique of their development. Current Perspectives on Molecular and Cellular Oncology 1(B): 311-329, 1992.
5. Kelsen D and Rosenbluth R et al: A phase III comparison trial of streptozotocin, mitomycin and 5FU with cisplatin, cytosine arabinoside, and caffeine in patients with advanced pancreatic carcinoma. Cancer 68: 965-969, 1991.
6. Verweij J and Pinedo HM: Mitomycin C: mechanism of action, usefulness and limitations. Anti-Cancer Drugs 1(1): 5-13, 1990.
7. Furukawa T, Kubota T, Watanabe M, Kitajima M and Hoffman RM: A novel ́patient-liké treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tissue in nude mice. Cancer Res 53: 3070-3072, 1993.
8. Chang BK, and Grefory JA: Comparison of the cellular pharmacology of doxorubicin in resistant and sensitive models of pancreatic cancer. Cancer Chemother Pharmacol 14: 132-134, 1985.
9. Vezeridis MP, Doremus CM, Tibbetts LM, Tzanakakis G and Jackson BT: Invasion and metastasis following orthotopic transplantation of human pancreatic cancer in the nude mice. J Surg Oncol 40: 261-265, 1989.
10. Hoffman RM: Orthotopic is orthodox: Why are orthotopic-transplant metastatic models different from all other models? J Cell Biochem 56: 1-4, 1994.
11. Fu X, Besterman JM, Monosov A and Hoffman RM: Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically-intact patient specimens. Proc Natl Acad Sci USA 88: 9345-9349, 1991.
12. Fu X and Hoffman RM: Human ovarian carcinoma metastatic models constructed in nude mice by orhtotopic transplantation of histologically-intact patient specimens. Anticancer Res 13: 283-286, 1993.
13. Fu X, Le P and Hoffman RM: A metastatic orthotopic transplant nude-mouse model of human breast cancer. Anticancer Res 13: 901-904, 1993.
14. Wang X, Fu X and Hoffman RM: A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice, Anticancer Res 12: 1403-1406, 1994.
15. Astoul P, Colt HG, Wang X and Hoffman RM: A ́patient-liké nude mouse model of parietal human lung adenocarcinoma. Anticancer Res 14: 85-91, 1994.
16. Wang X, Fu X and Hoffman RM: A patient-like metastasizing model of human lung adenocarcinoma constructed via thoracotomy in nude mice. Anticancer Res 12: 1399-1401, 1992.
17. Fu X, Theodorescu D, Kerbel RS and Hoffman RM: Extensive multiorgan metastasis following orthotopic onplantation of histologically-intact human bladder carcinoma tissue in nude mice. Int J Cancer 49: 938-939, 1991.
18. Astoul P, Colt HG, Wang X, Boutin C and Hoffman RM: A ́patient-liké nude-mouce model of advanced human pleural cancer. J Cellular Blochem 56: 9-15, 1994.