Effects of calcium antagonists on hepatic and systemic hemodynamics in awake portal hypertensive rats

Journal of Gastroenterology

Volumn 31, Issue 3, 1996, Pages 366-372

  Nagasawa, Masamichi ^a   Kawasaki, Tsunehisa ^a   Yoshimi, Teruya ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcium antagonist; Diltiazem; Hemodynamics; Nicardipine; Portal hypertension

Indexed keywords

CALCIUM ANTAGONIST; DILTIAZEM; NICARDIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART INDEX; HEMODYNAMICS; LIVER BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT; SPLANCHNIC BLOOD FLOW; VASCULAR RESISTANCE;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CONSCIOUSNESS; DILTIAZEM; HEMODYNAMIC PROCESSES; HYPERTENSION, PORTAL; LIVER CIRCULATION; MALE; NICARDIPINE; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION; TIME FACTORS; VASCULAR RESISTANCE;

EID: 0029897513     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02355026     Document Type: Article

References (32)

1. Fleig WE. Pharmacological methods for the prevention of first and recurrent bleeding from esophagogastric varices. Z Gastroenterol [Suppl 2] 1988;26:40-48.
2. Straumann A, Gyr K, Bruendler H, et al. Hemodynamic effects of nifedipine on hepatic venous pressure gradient in patients with portal hypertension. Hepatogastroenterology 1986;33:101-104.
3. Vorobioff J, Bredfeldt JE, Grozsmann RJ. Increased blood flow through the portal system in cirrhotic rats. Gastroenterology 1984;87:1120-1126.
4. Benoit JN, Womack WA, Hernandez L, et al. "Forward" and "backward" flow mechanism of portal hypertension. Gastroenterology 1985:89:1092-1096.
5. Roulot D, Braillon A, Gaudin C, et al. Mechanisms of clonidine-induced decrease in portal pressure in normal and cirrhotic conscious rats. Hepatology 1989;10:477-481.
6. Kroeger RJ, Groszmann RJ. The effect of a combination of nitroglycerin and propranolol on splanchnic and systemic hemodynamics in a portal hypertensive rat model. Hepatology 1985;5:425-430.
7. Mastai R, Rocheleau B, Huet PM. Serotonin blockade in conscious, unrestrained cirrhotic dogs with portal hypertension. Hepatology 1989;9.265-268.
8. Reichen J, Le M. Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver. J Clin Invest 1986;78:448-455.
9. Freeman JG, Barton JR, Record CO. Effect of isosorbide dinitrate, verapamil and labetalol on portal pressure in cirrhosis. Br Med J 1985;291:561-562.
10. Kong CW, Lay CS, Tsai YT, et al. The hemodynamic effect of verapamil on portal hypertension in patients with postnecrotic cirrhosis. Hepatology 1986;6:423-426.
11. Thiel DHV, Gavaler JS, Slone FL, et al. Is feminization in alcoholic men due in part to portal hypertension? A rat model. Gastroenterology 1980;78:81-91.
12. Verma-Ansil B, Carmichael FJ, Saldivia V, et al. Effect of ethanol on splanchnic hemodynamics in awake and unrestrained rats with portal hypertension. Hepatology 1989;10:946-952.
13. Chojkier M, Groszmann RJ. Measurement of portal-systemic shunting in the rat by using γ-labeled microspheres. Am J Physiol 1981;240:G371-G375.
14. Koshy A, Girod C, Lee SS, et al. Discrepancy between portal pressure and systemic hemodynamic changes after incremental doses of propranolol in awake portal hypertensive rats. Hepatology 1989;9:269-273.
15. Kawasaki T, Carmichael FJ, Giles G, et al. Effects of propylthiouracil and methimazole on splanchnic hemodynamics in awake and unrestrained rats. Hepatology 1989;10:273-278.
16. Kawasaki T, Carmichael FJ, Saldivia V, et al. Relationship between portal venous and hepatic arterial blood flows: spectrum of response. Am J Physiol 1990;259:G1010-G1018.
17. McKaigney JP, Carmichael FJ, Saldivia V, et al. Role of ethanol metabolism in the ethanol-induced increase in splanchnic circulation. Am J Physiol 1986;250:G518-G523.
18. Hadengue A, Lee SS, Koshy A, et al. Regional blood flows by the microsphere method: reproducibility in portal hypertensive rats and influence of a portal vein catheter. Proc Soc Exp Biol Med 1988;187:461-468.
19. Lebrec D, Poynard T, Bernuau J, et al. A randomized controlled study of propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: A final report. Hepatology 1984;4:355-358.
20. Reichen J, Lebrec D. The effect of drugs on the portal circulation. J Hepatol 1987;5:235-240.
21. Hadengue A, Moreau R, Cerini R, et al. Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: search for an additive effect. Hepatology 1989;9:83-87.
22. Navasa M, Bosch J, Reichen J, et al. Effects of verapamil on hepatic and systemic hemodynamics and liver function in patients with cirrhosis and portal hypertension. Hepatology 1988;8:850-854.
23. Merkel C, Gatta A, Bolognesi M, et al. The calcium-channel blocker, verapamil, does not improve portal pressure in patients with alcoholic cirrhosis. Br J Clin Pharmacol 1988;26:273-277.
24. Flaim SF, Zelis R. Effects of diltiazem on total cardiac output distribution in conscious rats. J Pharmacol Exp Ther 1982; 222:359-366.
25. 2-receptor populations Br J Pharmacol 1977; 60:123-133.
26. Pizcueta MP, Lacy AM, Kravetz D, et al. Propranolol decreases portal pressure without changing portocollateral resistance in cirrhotic rats. Hepatology 1989;10:953-957.
27. Kroeger RJ, Groszmann RJ. Increased portal venous resistance hinders portal pressure reduction during the administration of β-adrenergic blocking agents in a portal hypertensive model Hepatology 1985;5:97-101.
28. Desmorat H, Vinel JP, Lahlou O, et al. Systemic and splanchnic hemodynamic effects of molsidomine in rats with carbon tetrachloride-induced cirrhosis. Hepatology 1991;13:1181-1184.
29. Oberti F, Sogni P, Cailmail S, et al. Role of prostacyclin in hemodynamic alterations in conscious rats with extrahepatic or intrahepatic portal hypertension. Hepatology 1993;18:621-627.
30. Jetley M, Weston AH. Some effects of sodium nitroprusside, methoxyverapamil (D600) and nifedipine on rat portal vein. Br J Pharmacol 1980;68:311-319.
31. Karaki H, Weiss GB. Calcium channels in smooth muscle. Gastroenterology 1984;87:960-970.
32. Ohmiya A. Experimental studies on hepatic circulation: Effects of some drugs on blood flow in liver tissue and portal vein of cats. Jpn J Smooth Muscle Res 1986;22:483-492.