Buthionine sulfoximine induction of γ-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells

Molecular Pharmacology

Volumn 49, Issue 6, 1996, Pages 1012-1020

  Ali Osman, Francis ^a   Antoun, Gamil ^a   Wang, Hui ^a   Rajagopal, Sriram ^a   Gagucas, Evangeline ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; CARMUSTINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE;

ARTICLE; CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GLIOBLASTOMA; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DNA INTERACTION;

ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; BUTHIONINE SULFOXIMINE; CARMUSTINE; CELL SURVIVAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLIOMA; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; KINETICS; METHIONINE SULFOXIMINE; MOLECULAR SEQUENCE DATA;

EID: 0029897434     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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